Mechanisms of Fibroblast Growth Factor-2 Modulation of Vascular Endothelial Growth Factor Expression by Osteoblastic Cells

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring

1995 • 1,166 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Biological Roles of Fibroblast Growth Factor-2*

1997 • 892 citations

Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis

1998 • 829 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Quantification of cells cultured on 96-well plates

1989 • 644 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.

1994 • 548 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Biological Roles of Fibroblast Growth Factor-2

1997 • 434 citations

Growth factors for bone growth and repair: IGF, TGFβ and BMP

1996 • 432 citations

Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.

1994 • 393 citations

Induction of vasculogenesis and hematopoiesis in vitro

1992 • 345 citations

Regulation of Bovine Bone Cell Proliferation by Fibroblast Growth Factor and Transforming Growth Factorβ

1988 • 264 citations

Transforming growth factor-beta in the regulation of fracture repair.

1990 • 239 citations

Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta.

1997 • 226 citations

Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells.

1993 • 214 citations

Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I.

1996 • 209 citations

Gene Expression During Bone Repair

1993 • 209 citations

Transforming Growth Factor-β in the Regulation of Fracture Repair

1990 • 206 citations

Adaptive changes in trabecular architecture in relation to functional strain patterns and disuse

1996 • 205 citations

Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor

1997 • 193 citations

The Effects of Fibroblast Growth Factor-2 on Human Neonatal Calvaria Osteoblastic Cells Are Differentiation Stage Specific

1998 • 186 citations

Osteonecrosis of Bone

1986 • 178 citations

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.

1991 • 178 citations

Chemotactic response of osteoblastlike cells to transforming growth factorβ

1990 • 176 citations

TGF-β1, TGF-β2, and TGF-β3 Exhibit Distinct Patterns of Expression During Cranial Suture Formation and Obliteration In Vivo and In Vitro

1997 • 170 citations

Role of vascular endothelial cells in bone biology

1994 • 167 citations

Transforming growth factor-β1 modulates the expression of vascular endothelial growth factor by osteoblasts

1999 • 166 citations

Endogenous Basic Fibroblast Growth Factor Is Implicated in the Vascularization of the Chick Embryo Chorioallantoic Membrane

1995 • 161 citations

Distribution of FGF‐2 suggests it has a role in chick limb bud growth

1993 • 144 citations

Comparison of Residual Osseous Mass Between Vascularized and Nonvascularized Onlay Bone Transfers

1983 • 140 citations

SOME HISTOPHYSIOLOGICAL PROBLEMS PECULIAR TO CALCIFIED TISSUES

1952 • 137 citations

Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells.

1989 • 125 citations

Increase of vascular endothelial growth factor mRNA expression by 1,25-dihydroxyvitamin D3 in human osteoblast-like cells

1996 • 123 citations

Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage.

1994 • 109 citations

Distribution of Fibroblast Growth Factor (FGF)-2 and FGF Receptor-1 Messenger RNA Expression and Protein Presence in the Mid-Trimester Human Fetus

1996 • 99 citations

Platelet-Derived Growth Factor Enhances Deoxyribonucleic Acid and Collagen Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Parietal Bone*

1989 • 96 citations

A Novel Angiogenic Molecule Produced at the Time of Chondrocyte Hypertrophy during Endochondral Bone Formation

1996 • 93 citations

Biology of bone endothelial cells

1990 • 93 citations

FGF-2 Induces Regeneration of the Chick Limb Bud

1994 • 82 citations

Adenovirus-mediated Transfer of a Truncated Transforming Growth Factor-β (TGF-β) Type II Receptor Completely and Specifically Abolishes Diverse Signaling by TGF-β in Vascular Wall Cells in Primary Culture

1996 • 80 citations

Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning

1995 • 77 citations

Adenovirus-Mediated Gene Therapy of Osteoblasts In Vitro and In Vivo

1999 • 66 citations

A Novel Growth-Promoting Factor Derived from Fetal Bovine Cartilage, Chondromodulin II

1996 • 64 citations

Selective stimulation of endothelial cell proliferation with inhibition of smooth muscle cell proliferation by fibroblast growth factor-1 plus heparin delivered from fibrin glue suspensions*

1995 • 62 citations

Changes in the vascular network during the formation of Haversian systems

1980 • 55 citations

Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts

1998 • 54 citations

Role of Transforming Growth Factor Beta in Bone Remodeling: A Review

1989 • 46 citations

Neural induction and patterning by fibroblast growth factor, notochord and somite tissue in Xenopus

1998 • 40 citations

Decreased Mitogenic and Osteogenic Responsiveness of Calvarial Osteoblasts Isolated from Aged Rats to Basic Fibroblast Growth Factor

1995 • 30 citations

A cartilage-derived inhibitor of neovascularization and metalloproteinases.

1993 • 19 citations

Modulation of Transforming Growth Factor-β Actions in Rat Osteoblast-like Cells: The Effects of bFGF and EGF

1989 • 16 citations

Immunohistochemical localization of fibroblast growth factor-2 in normal and brachymorphic mouse tibial growth plate and articular cartilage.

1997 • 15 citations

Basic fibroblast growth factor bound to cell substrate promotes cell adhesion, proliferation, and protease production in cultured endothelial cells

1992 • 11 citations