Polite DNA: Functional density and functional compatibility in genomes

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Evolutionary Rate at the Molecular Level

1968 • 3,608 citations

Evolutionary Divergence and Convergence in Proteins

1965 • 2,780 citations

Selfish DNA: the ultimate parasite

1980 • 2,095 citations

Selfish genes, the phenotype paradigm and genome evolution

1980 • 1,779 citations

Codon usage and tRNA content in unicellular and multicellular organisms.

1985 • 1,724 citations

Molecular drive: a cohesive mode of species evolution

1982 • 1,579 citations

The structure of histone-depleted metaphase chromosomes

1977 • 1,083 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

The Mosaic Genome of Warm-Blooded Vertebrates

1985 • 887 citations

Cryptic simplicity in DNA is a major source of genetic variation

1986 • 692 citations

Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox

1978 • 681 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster

1976 • 556 citations

Metaphase chromosome structure: Evidence for a radial loop model

1979 • 552 citations

Active chromatin

1982 • 549 citations

Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.

1980 • 531 citations

Pseudogenes as a paradigm of neutral evolution

1981 • 526 citations

Assembly and propagation of repressed and derepressed chromosomal states

1985 • 518 citations

Enhancers and eukaryotic gene transcription

1985 • 515 citations

Supercoils in human dna

1975 • 496 citations

Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNAase I

1980 • 486 citations

Fine Structure Genetic Analysis of a β-Globin Promoter

1986 • 479 citations

Compositional constraints and genome evolution

1986 • 451 citations

An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin

1982 • 448 citations

SINEs and LINEs: Highly repeated short and long interspersed sequences in mammalian genomes

1982 • 438 citations

MOLECULAR ARRANGEMENT AND EVOLUTION OF HETEROCHROMATIC DNA

1980 • 412 citations

Codon frequencies in 119 individual genes confirm corsistent choices of degenerate bases according to genome type

1980 • 370 citations

Sequence-directed curvature of DNA

1986 • 299 citations

The organization of genetic units in chromosomes

1967 • 299 citations

Determinants of heat shock-induced chromosome puffing

1985 • 281 citations

Nucleotide sequences of HS-α satellite DNA from kangaroo rat dipodomys ordii and characterization of similar sequences in other rodents

1977 • 279 citations

Influence of histone H1 on chromatin structure

1977 • 278 citations

A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin

1983 • 273 citations

The transcriptional regulation of Xenopus 5S RNA genes in chromatin: The roles of active stable transcription complexes and histone H1

1984 • 265 citations

Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus.

1986 • 257 citations

A Direct Approach to the Structure of Eukaryotic Chromosomes

1978 • 254 citations

Non-histone proteins and long-range organization of HeLa interphase DNA

1982 • 231 citations

Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos

1986 • 202 citations

Localization of DNAase I-sensitive sequences to specific regions of interphase nuclei

1985 • 197 citations

Propagation of globin DNAase i-hypersensitive sites in absence of factors required for induction: A possible mechanism for determination

1982 • 189 citations

Domains in Chromatin Structure

1978 • 186 citations

Evolution of Genetic Systems

1973 • 186 citations

Nucleosome Cores Have Two Specific Binding Sites for Nonhistone Chromosomal Proteins HMG 14 and HMG 17

1980 • 184 citations

Localized Highly Repetitive DNA Sequences in Vertebrate and Invertebrate Genomes

1985 • 181 citations

The location of nucleosomes in chromatin: specific or statistical?

1981 • 173 citations

Definition of 5‘ and 3‘ structural boundaries of the chromatin domain containing the ovalbumin multigene family.

1982 • 172 citations

A mouse α-globin-related pseudogene lacking intervening sequences

1980 • 162 citations

Duplikationen von Untereinheiten der chromosomalen DNS w�hrend der Evolution von Chironomus thummi

1965 • 153 citations

Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3′ end of H3 messenger RNA

1986 • 146 citations

Functional Organization in the Nucleus

1982 • 145 citations

Evolutionary processes and evolutionary noise at the molecular level

1976 • 138 citations

Rapidly evolving mouse alpha-globin-related pseudo gene and its evolutionary history.

1981 • 131 citations

Static and Initiator Protein-Enhanced Bending of DNA at a Replication Origin

1986 • 129 citations

The genetic analysis of D. melanogaster heterochromatin

1980 • 123 citations

Nucleosomes are phased along the mouse β-major globin gene in erythroid and nonerythroid cells

1986 • 119 citations

Appearance of a chromatin protein during the erythroid differentiation of Friend virus-transformed cells.

1977 • 118 citations

Sequence organization and genomic distribution of the major family of interspersed repeats of mouse DNA.

1982 • 116 citations

Codon usage and genome composition

1985 • 115 citations

Telomere replication, kinetochore organizers, and satellite DNA evolution.

1979 • 113 citations

The appearance of new structures and functions in proteins during evolution

1975 • 112 citations

Ribonucleoprotein structure in nascent hnRNA is nonrandom and sequence-dependent

1980 • 108 citations

The similarity of DNA sequences remaining bound to scaffold upon nuclease treatment of interphase nuclei and metaphase chromosomes

1979 • 107 citations

A + T-rich linkers define functional domains in eukaryotic DNA

1982 • 104 citations

Evolution of the β-globin gene cluster in man and the primates

1981 • 103 citations

“Haldane's Dilemma” and the Rate of Evolution

1968 • 103 citations

Novel partitioning of DNA cleavage sites for Drosophila topoisomerase II

1985 • 100 citations

Supercoiled DNA folded by non-histone proteins in cultured mammalian cells

1975 • 97 citations

hnRNA size and processing as related to different DNA content in two dipterans: Drosophila and aedes

1975 • 94 citations

Interphase nuclear matrix and metaphase scaffolding structures

1984 • 90 citations

Relation of Nucleosomes to DNA Sequences

1978 • 82 citations

Stability and reversibility of higher ordered structure of interphase chromatin: continuity of deoxyribonucleic acid is not required for maintenance of folded structure

1980 • 80 citations

Markov chain analysis finds a significant influence of neighboring bases on the occurrence of a base in eucaryotic nuclear DNA sequences both protein-coding and noncoding

1985 • 74 citations

Nonpackaging and packaging proteins of hnRNA in Drosophila melanogaster

1983 • 74 citations

Classification of loops of lampbrush chromosomes according to the arrangement of transcriptional complexes

1976 • 74 citations

A possible role of “inert” heterochromatin in cell differentiation. Action of and competition for “locking” molecules

1974 • 72 citations

Evolution ofDrosophila repetitive-dispersed DNA

1983 • 71 citations

The organization and expression of globin genes

1982 • 68 citations

The Evolution of Interspersed Repetitive DNA Sequences in Mammals and Other Vertebrates

1985 • 65 citations

Supercoiled loops and the organization of replication and transcription in eukaryotes

1985 • 57 citations

Subunit structure of chromatin and the organization of eukaryotic highly repetitive DNA: Nucleosomal proteins associated with a highly repetitive mammalian DNA

1977 • 56 citations

The Croonian Lecture, 1981 - Lampbrush chromosomes

1982 • 55 citations

Ignorant DNA?

1980 • 54 citations

Monoclonal antibodies to lampbrush chromosome antigens of Pleurodeles waltlii

1985 • 53 citations

Evolution of Ribonuclease in Relation to Polypeptide Folding Mechanisms

1972 • 53 citations

Chromosomes Isolated from Unfixed Salivary Glands of Chironomus

1972 • 52 citations

Immunofluorescent localization of transcriptional activity on lampbrush chromosomes

1978 • 47 citations

Chromosomes and Cytodifferentiation

1963 • 46 citations

Recent developments in the study of lampbrush chromosomes

1980 • 44 citations

Gene control in eukaryotes and thec-value paradox “Excess” DNA as an impediment to transcription of coding sequences

1976 • 42 citations

Control of puffing activity in three chromosomal segments of explanted salivary gland cells of Chironomus thummi by variation in extracellular Na+, K+ and Mg2+

1973 • 41 citations

Patterns of DNA structural polymorphism and their evolutionary implications

1984 • 40 citations

EVOLUTION OF GLOBIN GENES

1981 • 40 citations

Specific DNA sequences associated with the nuclear matrix in synchronized mouse 3T3 cells.

1983 • 39 citations

Transcriptionally active chromatin in loops of lampbrush chromosomes at physiological salt concentrations as revealed by electron microscopy of sections.

1981 • 39 citations

A general function of noncoding polynucleotide sequences

1981 • 38 citations

Histone H1 Involvement in the Structure of the Chromosome Fiber

1978 • 30 citations

In vitro assembly of a pre-messenger ribonucleoprotein.

1983 • 28 citations

Choice of base at silent codon site 3 is not selectively neutral in eucaryotic structural genes: It maintains excess short runs of weak and strong hydrogen bonding bases

1983 • 26 citations

The DNA sequences of cloned complex satellite DNAs from Hawaiian Drosophila and their bearing on satellite DNA sequence conservation

1981 • 25 citations

Ultrastructure of induced transitions in the chromatin organization of Drosophila polytene chromosomes

1970 • 21 citations

The Human Genome and Its Evolutionary Context

1986 • 21 citations

Codons and nearest-neighbor nucleotide pairs in mammalian messenger RNA

1978 • 17 citations

Sizes of chromosome loops and hnRNA molecules in oocytes of amphibia of different genome sizes

1982 • 15 citations

Mammalian Repetitive DNA and the Subunit Structure of Chromatin

1978 • 15 citations

Satellite DNA, H1 Histone, and Heterochromatin in Drosophila virilis

1978 • 12 citations

Structural polymorphism in DNA

1983 • 11 citations

Relationship of Blym genes to repeated sequences

1986 • 10 citations

Do jumping genes make evolutionary leaps?

1981 • 9 citations

[Remarks on the evolution of polynucleotides compared to that of polypeptides].

1965 • 7 citations

Persistence of Individuality of Chromosomes during Interphase, and the Role of the Nuclear Membrane

1973 • 2 citations

The morphology of normal and denatured polytene chromosomes from Drosophila melanogaster.

1979 • 2 citations