Homodimerization Restores Biological Activity to an Inactive Erythropoietin Mutant

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

1996 • 589 citations

The regulated expression of erythropoietin by two human hepatoma cell lines.

1987 • 374 citations

Receptor and Antibody Epitopes in Human Growth Hormone Identified by Homolog-Scanning Mutagenesis

1989 • 345 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7

1993 • 175 citations

A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice.

1983 • 167 citations

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7

1993 • 155 citations

An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene

1991 • 154 citations

Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure

1993 • 123 citations

Mapping of the Active Site of Recombinant Human Erythropoietin

1997 • 104 citations

Structure and Function of Human Growth Hormone: Implications for the Hematopoietins

1993 • 100 citations

Structural and functional basis for hormone binding and receptor oligomerization

1994 • 91 citations

Growth Hormone (GH) and a GH Antagonist Promote GH Receptor Dimerization and Internalization

1996 • 87 citations

Homodimerization of Erythropoietin Receptor by a Bivalent Monoclonal Antibody Triggers Cell Proliferation and Differentiation of Erythroid Precursors

1997 • 83 citations

Activation of the Erythropoietin (EPO) Receptor by Bivalent Anti-EPO Receptor Antibodies

1996 • 82 citations

Structure of the murine erythropoietin receptor complex. Characterization of the erythropoietin cross-linked proteins.

1991 • 77 citations

Erythropoietin structure-function relationships. Identification of functionally important domains.

1994 • 76 citations

A sequential dimerization mechanism for erythropoietin receptor activation.

1996 • 72 citations

Early events in erythropoietin-induced signaling.

1996 • 70 citations

Dimer- and Oligomerization of the Erythropoietin Receptor by Disulfide Bond Formation and Significance of the Region Near the WSXWS Motif in Intracellular Transport

1993 • 51 citations

Fine-structure epitope mapping of antierythropoietin monoclonal antibodies reveals a model of recombinant human erythropoietin structure

1996 • 40 citations

Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity

1993 • 38 citations

The Erythropoietin Receptor: Biogenesis, Dimerization, and Intracellular Signal Transduction

1995 • 32 citations

Isolation and characterization of conformation sensitive antierythropoietin monoclonal antibodies: effect of disulfide bonds and carbohydrate on recombinant human erythropoietin structure

1996 • 32 citations

Subunit structure of the erythropoietin receptor analyzed by 125I-Epo cross-linking in cells expressing wild-type or mutant receptors

1993 • 31 citations

Evidence for an accessory component that increases the affinity of the erythropoietin receptor.

1993 • 22 citations