Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: THE ALLOMETRIC APPROACH FOR INTERSPECIES SCALING OF PHARMACOKINETICS AND TOXICITY OF ANTI‐CANCER DRUGS

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

1966 • 1,363 citations

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

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Principles and methods of toxicology

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Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

1980 • 340 citations

Interspecies Pharmacokinetic Scaling and the Evolutionary-Comparative Paradigm

1984 • 271 citations

Pharmacologically Guided Phase I Clinical Trials Based Upon Preclinical Drug Development

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Biological basis for extrapolation across mammalian species

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Interspecies scaling and comparisons in drug development and toxicokinetics

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The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man

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Prediction of the disposition ofβ-lactam antibiotics in humans from pharmacokinetic parameters in animals

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Extrapolation of Toxicological and Pharmacological Data from Animals to Humans

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Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species

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Interspecies Extrapolation: A Reexamination of Acute Toxicity Data

1992 • 69 citations

The allometric approach for interspecies scaling of pharmacokinetic parameters

1992 • 61 citations

Interspecies Correlation of the Pharmacokinetics of Erythromycin, Oleandomycin, and Tylosin

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Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans.

1988 • 55 citations

Dosage Regimen Design for Pharmaceutical Studies Conducted in Animals

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Pharmacokinetic and toxicity scaling of the antitumor agents amsacrine and CI-921, a new analogue, in mice, rats, rabbits, dogs, and humans.

1990 • 46 citations

Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism

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Suitability of Animal Models for Predictive Toxicology: Theoretical and Practical Considerations

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Physiological pharmacokinetic models: principles, applications, limitations and outlook.

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Relationship of structure to anticancer activity and toxicity of the nitrosoureas in animal systems.

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Interspecies Metabolism and Pharmacokinetic Scaling of Theophylline Disposition

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Phencyclidine pharmacokinetic scaling among species.

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Prediction of ACNU plasma concentration-time profiles in humans by animal scale-up

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Isomerisation and urinary excretion of proxibarbal and valofan in man; a preliminary study

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