Potassium channel openers prevent potassium-induced calcium loading of cardiac cells: Possible implications in cardioplegia

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

The Pharmacology of ATP-Sensitive Potassium Channels

1993 • 530 citations

Calcium and Ischemic Injury

1986 • 529 citations

Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 445 citations

Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart.

1990 • 368 citations

Ischemic contracture of the heart: ?Stone heart?

1972 • 351 citations

Cellular and Subcellular Heterogeneity of [Ca ²⁺ ] _i in Single Heart Cells Revealed by Fura-2

1987 • 345 citations

Intracellular calcium homeostasis in cardiac myocytes.

1993 • 276 citations

Myocardial protection during ischemic cardiac arrest

1978 • 275 citations

Protection of the Ischemic Myocardium: Cardioplegia

1982 • 227 citations

Do the K+ channel openers relax smooth muscle by opening K+ channels?

1993 • 207 citations

Protection of the Ischemic Myocardium: Cardioplegia

1981 • 166 citations

Calcium-mediated damage during post-ischaemic reperfusion

1988 • 144 citations

Potassium channel openers: pharmacological and clinical aspects

1992 • 124 citations

Myocardial protection during ischemic cardiac arrest

1977 • 118 citations

K+ channel openers and ‘natural’ cardioprotection

1992 • 112 citations

The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes.

1991 • 109 citations

Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide.

1992 • 102 citations

Effect of cross-clamp time, temperature, and cardioplegic agents on myocardial function after induced arrest

1978 • 98 citations

Clinical Evidence for Stunned Myocardium After Coronary Artery Bypass Surgery

1994 • 82 citations

Cytoplasmic free calcium measured by quin2 fluorescence in isolated ventricular myocytes at rest and during potassium-depolarization

1984 • 72 citations

Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil

1990 • 72 citations

Increased left ventricular diastolic chamber stiffness immediately after coronary artery bypass surgery

1994 • 71 citations

Dualistic behavior of ATP-sensitive K+ channels toward intracellular nucleoside diphosphates

1994 • 69 citations

Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel. A comparison with pinacidil and lemakalim.

1991 • 62 citations

Protective effects of ATP sensitive potassium channel openers in models of myocardial ischaemia

1994 • 61 citations

Cold cardioplegia and the K⁺ channel modulator aprikalim (RP 52891): improved cardioprotection in isolated ischemic rabbit hearts

1994 • 53 citations

Calcium and sodium control in hypoxic-reoxygenated cardiomyocytes

1993 • 53 citations

Quantitative intracellular calcium imaging with laser-scanning confocal microscopy

1990 • 47 citations

Magnesium cardioplegia reduces cytosolic and nuclear calcium and DNA fragmentation in the senescent myocardium

1994 • 40 citations

Glibenclamide Specifically Blocks ATP-Sensitive K<+ Channel Current in Atrial Myocytes of Guinea Pig Heart

1990 • 39 citations

The effects of calcium and magnesium in hyperkalemic cardioplegic solutions on myocardial preservation

1989 • 36 citations

Intracellular acidification and ADP enhance nicorandil induction of ATP sensitive potassium channel current in cardiomyocytes

1994 • 32 citations

α-adrenergic regulation of action potentials in isolated rat cardiomyocytes

1989 • 30 citations

Spontaneous Calcium Waves without Contraction in Cardiac Myocytes

1995 • 27 citations

The risk of myocardial stunning is decreased concentration-dependently by KATP channel activation with nicorandil before high K+ cardioplegia

1995 • 26 citations

A textbook of cardioplegia for difficult clinical problems

1992 • 26 citations

Myocardial Cytosolic Calcium Accumulation During Ischemia/Reperfusion: The Effects of Aging and Cardioplegia

1994 • 26 citations

Hyperpolarized Arrest Attenuates Myocardial Stunning Following Global Surgical Ischemia: An Alternative to Traditional Hyperkalemic Cardioplegia?

1994 • 22 citations

Myocardial preservation related to magnesium content of hyperkalemic cardioplegic solutions at 8 °C

1989 • 18 citations

Levcromakalim-induced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery

1994 • 18 citations

Developmental differences in the response of cytosolic free calcium to potassium depolarization and cardioplegia in cardiac myocytes

1992 • 16 citations

Cardioplegia for the immature myocardium

1990 • 15 citations

Cyclic ADP-Ribose-Induced Calcium Release in Sea Urchin Egg Homogenates Is a Cooperative Process

1995 • 7 citations

Comparison of potassium and adenosine cardioplegia with or without verapamil in the isolated guinea pig heart

1992 • 3 citations