Do the K+ channel openers relax smooth muscle by opening K+ channels?

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel

1993 • 935 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels

1990 • 600 citations

The Pharmacology of ATP-Sensitive Potassium Channels

1993 • 530 citations

Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein

1986 • 481 citations

Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels

1990 • 458 citations

Potassium channel modulators: scientific applications and therapeutic promise

1990 • 212 citations

An activator of calcium-dependent potassium channels isolated from a medicinal herb

1993 • 203 citations

In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.

1989 • 201 citations

Membrane hyperpolarization inhibits agonist‐induced synthesis of inositol 1,4,5‐trisphosphate in rabbit mesenteric artery.

1992 • 188 citations

Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets

1989 • 174 citations

Cyclic GMP as Possible Mediator of Coronary Arterial Relaxation by Nicorandil (SG-75)

1983 • 165 citations

Regulation of Adenylyl Cyclase from Paramecium by an Intrinsic Potassium Conductance

1992 • 156 citations

Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries.

1981 • 150 citations

A role for inositol 1,4,5‐trisphosphate in the initiation of agonist‐induced contractions of dog tracheal smooth muscle

1985 • 140 citations

Potassium channel openers: pharmacological and clinical aspects

1992 • 124 citations

A specific binding site for K+ channel openers in rat aorta.

1992 • 118 citations

Anti‐vasoconstrictor effects of the K⁺ channel opener cromakalim on the rabbit aorta—comparison with the calcium antagonist isradipine

1988 • 85 citations

Effects of lemakalim on changes in Ca²⁺concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery

1991 • 78 citations

Binding of the K+ channel opener [3H]P1075 in rat isolated aorta: relationship to functional effects of openers and blockers.

1993 • 73 citations

Differences between the effects of cromakalim and nifedipine on agonist‐induced responses in rabbit aorta

1991 • 69 citations

Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227)

1992 • 60 citations

BRL 38227 (levcromakalim)-induced hyperpolarization reduces the sensitivity to Ca2+ of contractile elements in canine coronary artery

1993 • 57 citations

K+ channel openers, cromakalim and Ki4032, inhibit agonist-induced Ca2+ release in canine coronary artery

1992 • 56 citations

Comparison of the effluxes of 42K+ and 86Rb+ elicited by cromakalim (BRL 34915) in tonic and phasic vascular tissue

1988 • 55 citations

Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit

1992 • 40 citations

Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta

1992 • 35 citations

Effects of rubidium on responses to potassium channel openers in rat isolated aorta

1993 • 32 citations

Potassium channel openers dilate large epicardial coronary arteries in conscious dogs by an indirect, endothelium-dependent mechanism.

1992 • 26 citations

Effects of P1060 and aprikalim on whole‐cell currents in rat portal vein; inhibition by glibenclamide and phentolamine

1993 • 26 citations

Cromakalim inhibits contractions of the rat isolated mesenteric bed induced by noradrenaline but not caffeine in Ca2+-free medium: Evidence for interference with receptor-mediated Ca2+ mobilization

1991 • 24 citations

Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol‐ and histamine‐stimulated phosphoinositide metabolism in airway smooth muscle

1992 • 24 citations

E4080 has a dual action, as a K+ channel opener and a Ca2+ channel blocker, in canine coronary artery smooth muscle

1992 • 21 citations

Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca²⁺

1989 • 20 citations

Cromakalim inhibits electrically-evoked [3H] acetylcholine release from a tube-preparation of the rat isolated trachea by an epithelium-dependent mechanism

1993 • 16 citations

KCl-Depolarization Potentiates the Ca2+Sensitization by Endothelin-1 in Canine Coronary Artery

1992 • 11 citations

Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea

1992 • 7 citations