Uncontrollable Stress Potentiates Morphine's Rewarding Properties
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Abstract
References (75)
The Nervous System
1991 • 2,567 citations
Learned helplessness: Theory and evidence.
1976 • 2,255 citations
Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration
1990 • 574 citations
Drug reinforcement studied by the use of place conditioning in rat
1982 • 482 citations
Stress-Induced Facilitation of Classical Conditioning
1992 • 312 citations
Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release
1989 • 277 citations
Long-Term Stress-Induced Analgesia and Activation of the Opiate System
1981 • 266 citations
Brain reward circuitry: Four circuit elements “wired” in apparent series
1984 • 257 citations
Stress: From synapse to syndrome.
1993 • 245 citations
Reinforcing effects of brain microinjections of morphine revealed by conditioned place preference
1982 • 238 citations
Effect of early and later colony housing on oral ingestion of morphine in rats
1981 • 227 citations
Stress-induced sensitization to amphetamine and morphine psychomotor effects depend on stress-induced corticosterone secretion
1992 • 205 citations
Conditional analgesia, defensive freezing, and benzodiazepines.
1988 • 199 citations
Inescapable footshocks induce progressive and long-lasting behavioural changes in male rats
1992 • 198 citations
Preferential Stimulation of Dopamine Release in the Nucleus Accumbens by Opiates, Alcohol, and Barbiturates: Studies with Transcerebral Dialysis in Freely Moving Rats
1986 • 176 citations
5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward
1989 • 176 citations
The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.
1993 • 168 citations
Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats
1994 • 167 citations
Conditioned place preference paradigm: a novel approach for analgesic drug assessment against chronic pain
1994 • 160 citations
8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.
1995 • 159 citations
Role of fear in mediating shuttle escape learning deficit produced by inescapable shock.
1990 • 157 citations
Differential regulation of 5‐hydroxytryptamine release by GABAA and GABAB receptors in midbrain raphe nuclei and forebrain of rats
1996 • 144 citations
Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour
1985 • 142 citations
Sensitization to the psychomotor effects of amphetamine and morphine induced by food restriction depends on corticosterone secretion
1993 • 140 citations
Learned helplessness, inactivity, and associative deficits: Effects of inescapable shock on response choice escape learning.
1980 • 132 citations
Stressor controllability and the pituitary-adrenal system.
1986 • 132 citations
Influence of housing conditions on the acquisition of intravenous heroin and cocaine self-administration in rats
1989 • 132 citations
Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons
1994 • 126 citations
Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function
1993 • 125 citations
Stressor controllability, social interaction, and benzodiazepine systems
1993 • 118 citations
An anxiogenic benzodiazepine receptor ligand induces learned helplessness
1985 • 118 citations
The effect of housing and gender on preference for morphine-sucrose solutions in rats
1979 • 114 citations
Exposure to inescapable shock produces both activity and associative deficits in the rat
1978 • 112 citations
Exposure to inescapable stress persistently facilitates associative and nonassociative learning in rats.
1994 • 99 citations
Aversive and antiaversive effects of morphine in the dorsal periaqueductal gray of rats submitted to the elevated plus-maze test
1993 • 93 citations
Social isolation-induced enhancement of the psychomotor effects of morphine depends on corticosterone secretion
1994 • 91 citations
Multisystem Regulation of Performance Deficits Induced by Stressors: An Animal Model of Depression
2003 • 86 citations
Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning
1992 • 86 citations
Increased Extracellular Serotonin in Rat Brain After Systemic or Intraraphe Administration of Morphine
1994 • 84 citations
Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine
1982 • 83 citations
Failure to establish a conditioned place preference with ethanol in rats
1985 • 81 citations
Modulation of anxiety by β-carbolines and other benzodiazepine receptor ligands: Relationship of pharmacological to biochemical measures of efficacy
1987 • 80 citations
Effect of stress on oral morphine and fentanyl self-administration in rats
1992 • 79 citations
An examination of heroin conditioning in preferred and nonpreferred environments and in differentially housed mature and immature rats
1985 • 76 citations
Single-trial conditioned place preference using intravenous morphine
1986 • 75 citations
Preexposure to foot-shock sensitizes the locomotor response to subsequent systemic morphine and intra-nucleus accumbens amphetamine
1990 • 73 citations
The dorsal raphe nucleus is a site of action mediating the behavioral effects of benzodiazepine receptor inverse agonist DMCM.
1995 • 73 citations
Partial anxiolytic action of morphine sulphate following microinjection into the central nucleus of the amygdala in rats
1979 • 72 citations
The effects of putative anxiogenic compounds (FG 7142, CGS 8216 and Ro 15-1788) on the rat corticosterone response
1985 • 72 citations
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine
1996 • 72 citations
Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testing.
1994 • 70 citations
Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on “relapse” to opioid drugs
1993 • 68 citations
Measuring morphine's capacity to establish a place preference
1989 • 65 citations
Effect of social isolation on the reinforcing properties of morphine in the conditioned place preference test
1996 • 64 citations
Animal Models in Psychiatry, II
1991 • 63 citations
Potentiation of morphine analgesia in rats given a single exposure to restraint stress immobilization
1992 • 59 citations
Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm
1993 • 45 citations
Light microscopic immunocytochemical evidence of converging serotonin and dopamine terminals in ventrolateral nucleus accumbens
1995 • 43 citations
Temporal factors in the effect of restraint stress on morphine-induced behavioral sensitization in the rat
1995 • 42 citations
Presynaptic serotonin mechanisms in rats subjected to inescapable shock
1992 • 37 citations
Reciprocal changes in the firing rate of neostriatal and dorsal raphe neurons following local infusions or systemic injections of D- amphetamine: evidence for neostriatal heterogeneity
1983 • 31 citations
Inescapable shock-induced potentiation of morphine analgesia in rats: Involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus.
1997 • 31 citations
The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission
1993 • 30 citations
A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO
1992 • 29 citations
Chronic variable stress enhances the stimulatory action of a low dose of morphine: reversal by desipramine
1994 • 29 citations
The nature of the activity deficit produced by inescapable shock
1982 • 28 citations
Effects of restraint stress and intra-ventral tegmental area injections of morphine and methyl naltrexone on the discriminative stimulus effects of heroin in the rat
1995 • 23 citations
Direct comparison of hallucinogenic phenethylamines and d-amphetamine on dorsal raphe neurons
1986 • 19 citations
Modulation of hypoalgesia by morphine and number of shock trials: Covariation of a measure of context fear and hypoalgesia
1994 • 17 citations
Inescapable shock-induced potentiation of morphine analgesia.
1997 • 16 citations
Serotonergic dorsal raphe neurons: Subsensitivity to amphetamine with long-term treatment
1987 • 15 citations
Restricted feeding does not modify discriminative stimulus effects of morphine in the rat
1988 • 14 citations
Unpredictable/uncontrollable stress proactively interferes with appetitive Pavlovian conditioning
1990 • 7 citations
Interaction of stress and morphine in the rat using a classical conditioning design
1980 • 5 citations
Conditioned fear exacerbates acute morphine dependence
1995 • 5 citations