Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

2011 • 2,430 citations

Incidence of Parkinson's Disease: Variation by Age, Gender, and Race/Ethnicity

2003 • 1,633 citations

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

2011 • 1,134 citations

The effects of hormones on sex differences in infection: from genes to behavior

2000 • 792 citations

The Human Serum Paraoxonase/Arylesterase Gene (PON1) Is One Member of a Multigene Family

1996 • 679 citations

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

2005 • 677 citations

Sex Differences in Coronary Heart Disease

1997 • 653 citations

Paraoxonase-2 Is a Ubiquitously Expressed Protein with Antioxidant Properties and Is Capable of Preventing Cell-mediated Oxidative Modification of Low Density Lipoprotein

2001 • 454 citations

Human Serum Paraoxonase/Arylesterase’s Retained Hydrophobic N -Terminal Leader Sequence Associates With HDLs by Binding Phospholipids

1999 • 322 citations

Paraoxonase-2 Reduces Oxidative Stress in Vascular Cells and Decreases Endoplasmic Reticulum Stress–Induced Caspase Activation

2007 • 237 citations

Antagonists Selective for Estrogen Receptor α

2002 • 227 citations

Actions of estrogens on glial cells: Implications for neuroprotection

2009 • 197 citations

Mitochondrial mechanisms of estrogen neuroprotection

2009 • 191 citations

Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues

2008 • 190 citations

Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence

1998 • 182 citations

Glutamate Cysteine Ligase Modifier Subunit Deficiency and Gender as Determinants of Acetaminophen-Induced Hepatotoxicity in Mice

2007 • 178 citations

Paraoxonase 2 Deficiency Alters Mitochondrial Function and Exacerbates the Development of Atherosclerosis

2010 • 165 citations

Mouse Macrophage Paraoxonase 2 Activity Is Increased Whereas Cellular Paraoxonase 3 Activity Is Decreased Under Oxidative Stress

2003 • 162 citations

Paraoxonase-2 Deficiency Aggravates Atherosclerosis in Mice Despite Lower Apolipoprotein-B-containing Lipoproteins

2006 • 154 citations

Dominant Role of Paraoxonases in Inactivation of the Pseudomonas aeruginosa Quorum-Sensing Signal N -(3-Oxododecanoyl)- <scp>l</scp> -Homoserine Lactone

2008 • 154 citations

Of Mice and Women: The Bias in Animal Models

2010 • 154 citations

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

2010 • 147 citations

One Enzyme, Two Functions

2010 • 144 citations

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

2010 • 143 citations

Paraoxonase-2 deficiency enhancesPseudomonas aeruginosaquorum sensing in murine tracheal epithelia

2006 • 139 citations

Pyrazolo[1,5-a]pyrimidines: Estrogen Receptor Ligands Possessing Estrogen Receptor β Antagonist Activity.

2005 • 138 citations

Neuroprotective actions of estradiol revisited

2011 • 131 citations

Implications of gender differences for human health risk assessment and toxicology

2006 • 102 citations

Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels

2008 • 100 citations

Acetaminophen Metabolism Does Not Contribute to Gender Difference in Its Hepatotoxicity in Mouse

2006 • 98 citations

Neurotoxicity of Domoic Acid in Cerebellar Granule Neurons in a Genetic Model of Glutathione Deficiency

2006 • 95 citations

The Female Advantage in Cardiovascular Disease: Do Vascular Beds Contribute Equally?

2007 • 95 citations

Human tissue distribution of paraoxonases 1 and 2 mRNA

2010 • 92 citations

Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions

2007 • 91 citations

Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: Selective secretion of PON1 and PON2

2005 • 82 citations

Paraoxonase 2 (PON2) in the mouse central nervous system: A neuroprotective role?

2011 • 80 citations

Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats

2011 • 79 citations

Female Adult Mouse Cardiomyocytes Are Protected Against Oxidative Stress

2010 • 75 citations

Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats

2007 • 70 citations

Age and gender differences in behavioral and morphological outcome after 6-hydroxydopamine-induced lesion of the substantia nigra in rats

2004 • 67 citations

Neurotoxic exposures and effects: Gender and sex matter! Hänninen Lecture 2011

2012 • 61 citations

A Common Mutation in Paraoxonase-2 Results in Impaired Lactonase Activity

2009 • 59 citations

Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-<scp>L</scp>-homoserine lactone and attenuates oxidative stress induced by pyocyanin

2009 • 58 citations

Age and sex-related changes in rat brain mitochondrial oxidative status

2011 • 56 citations

Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons

2010 • 55 citations

Estrogen and the regulation of mitochondrial structure and function in the brain

2012 • 51 citations

Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase

2012 • 50 citations

Sex differences in methamphetamine toxicity in mice: Effect on brain dopamine signaling pathways

2011 • 47 citations

Same sex, no sex, and unaware sex in neurotoxicology

2010 • 46 citations

Sex‐ and brain region‐specific role of cytochrome c oxidase in 1‐methyl‐4‐phenylpyridinium‐mediated astrocyte vulnerability

2011 • 42 citations

Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members

2009 • 41 citations

Gender and manganese exposure interactions on mouse striatal neuron morphology

2011 • 40 citations

Mycobacterial infections in a large Virginia hospital, 2001-2009

2011 • 40 citations

Cytokines and Growth Factors Induce HSP27 Phosphorylation in Human Astrocytes

1995 • 36 citations

Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

2011 • 32 citations

Paraoxonases-2 and -3 Are Important Defense Enzymes againstPseudomonas aeruginosaVirulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties

2012 • 30 citations

Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity

2010 • 16 citations

Chronic Intermittent Hypoxia Induces Thioredoxin System Changes in a Gender-Specific Fashion in Mice

2011 • 11 citations