Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

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Incidence of Parkinson's Disease: Variation by Age, Gender, and Race/Ethnicity

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Mitochondrial metabolism of reactive oxygen species

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Gonadal Steroid Induction of Structural Sex Differences in the Central Nervous System

1984 • 1,170 citations

Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

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Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro.

1978 • 936 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Gender differences in Parkinson's disease

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Are men at greater risk for Parkinson's disease than women?

2004 • 652 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

2007 • 561 citations

Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment

2001 • 520 citations

Ovarian steroids and the brain

1997 • 481 citations

Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons

1999 • 393 citations

Parkinson's disease

1990 • 338 citations

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

2005 • 304 citations

Increased risk of parkinsonism in women who underwent oophorectomy before menopause

2007 • 294 citations

Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7.

1995 • 272 citations

Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine

1995 • 270 citations

Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria

2008 • 264 citations

Neurodegeneration and neuroprotection in Parkinson disease

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Estradiol upregulates Bcl-2 expression in adult brain neurons

1998 • 253 citations

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

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Cell Respiration is Controlled by ATP, an Allosteric Inhibitor of Cytochrome-c Oxidase

1997 • 229 citations

Low Reserve of Cytochrome c Oxidase Capacity in Vivo in the Respiratory Chain of a Variety of Human Cell Types

1998 • 214 citations

Lactate as a pivotal element in neuron–glia metabolic cooperation

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Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3‐nitroproprionic acid in SK‐N‐SH human neuroblastoma cells

2001 • 203 citations

Mitochondrial mechanisms of estrogen neuroprotection

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Estrogen decreases corpus striatal neurotoxicity in response to 6-hydroxydopamine

1997 • 144 citations

Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling

2000 • 136 citations

The intramitochondrial ATP/ADP‐ratio controls cytochrome c oxidase activity allosterically¹

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Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.

2001 • 115 citations

Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson's Disease

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Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons

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The Effects of Steroid Hormones on the Transcription of Genes Encoding Enzymes of Oxidative Phosphorylation

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Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population

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Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons

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Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target

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Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain

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Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line.

1993 • 85 citations

Estrogen Induction of Cytochrome c Oxidase Subunit III in Rat Hippocampus

1992 • 84 citations

A second mechanism of respiratory control

1999 • 84 citations

Estrogen and the development and protection of nigrostriatal dopaminergic neurons: Concerted action of a multitude of signals, protective molecules, and growth factors

2006 • 84 citations

Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoraductase by rotenone, piericidin A, and MPP+

1992 • 75 citations

Sex steroids promote neurite growth in mesencephalic tyrosine hydroxylase immunoreactive neurons in vitro

1987 • 68 citations

Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid

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Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells

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Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatment

1999 • 60 citations

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

2008 • 60 citations

Enhanced Mitochondrial Gene Transcript, ATP, Bcl-2 Protein Levels, and Altered Glutathione Distribution in Ethinyl Estradiol-Treated Cultured Female Rat Hepatocytes

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Differentiative Effects of Dopamine on Striatal Neurons Involve Stimulation of the cAMP/PKA Pathway

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Implications for Estrogens in Parkinson's Disease

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Competitive irreversible inhibition of dopamine uptake by 6-hydroxydopamine.

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Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study

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Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERα in primary cultures of mouse mesencephalon

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Oestrogen Influences on Mitochondrial Gene Expression and Respiratory Chain Activity in Cortical and Mesencephalic Astrocytes

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Cytochrome c oxidase isoform IV‐2 is involved in 3‐nitropropionic acid‐induced toxicity in striatal astrocytes

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Dopaminergic Phenotype Induced by Oestrogens in a Human Neuroblastoma Cell Line

1997 • 34 citations

Effects of Age, Gender, and Gonadectomy on Neurochemistry and Behavior in Animal Models of Parkinson's Disease

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Effect of administration of 2-methyl-4-dimethylaminoazobenzene on the half-lives of rat liver mitochondria and cytochrome oxidase

1985 • 13 citations