Changing Mechanisms of Bacterial Resistance

An Enzyme from Bacteria able to Destroy Penicillin

1940 • 1,283 citations

[57] Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria

1975 • 839 citations

Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

1977 • 828 citations

THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN)

1974 • 765 citations

INFECTIVE HEREDITY OF MULTIPLE DRUG RESISTANCE IN BACTERIA

1963 • 729 citations

The β-Lactamases of Gram-Negative Bacteria and their Possible Physiological Role

1973 • 719 citations

Emergence of Multiply Resistant Pneumococci

1978 • 643 citations

Penicillinase Synthesis Controlled By Infectious R Factors In Enterobacteriaceae

1965 • 555 citations

The β-lactamases of Gram-negative bacteria and their rôle in resistance to β-lactam antibiotics

1976 • 539 citations

Extraction of a Highly Potent Penicillin Inactivator from Penicillin Resistant Staphylococci

1944 • 487 citations

The Mechanism of the Irreversible Antimicrobial Effects of Penicillins: How the Beta-Lactam Antibiotics Kill and Lyse Bacteria

1979 • 427 citations

Bacterial resistance to aminoglycoside antibiotics

1997 • 397 citations

Rifampin: Mechanisms of Action and Resistance

1983 • 372 citations

Changes in Intestinal Flora of Farm Personnel after Introduction of a Tetracycline-Supplemented Feed on a Farm

1976 • 350 citations

Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria

1984 • 348 citations

Infectious multiple drug resistance.

1975 • 345 citations

$bgr;-LACTAMASE-PRODUCING, PENICILLIN-RESISTANT GONOCOCCUS

1976 • 342 citations

INFECTIVE HEREDITY OF MULTIPLE DRUG RESISTANCE IN BACTERIA

1963 • 337 citations

STREPTOCOCCUS PNEUMONIÆ RESISTANT TO PENICILLIN AND CHLORAMPHENICOL

1977 • 328 citations

Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man

1976 • 314 citations

Plasmids, drug resistance, and gene transfer in the genus Streptococcus

1981 • 279 citations

Effects of Membrane-Energy Mutations and Cations on Streptomycin and Gentamicin Accumulation by Bacteria: a Model for Entry of Streptomycin and Gentamicin in Susceptible and Resistant Bacteria

1977 • 276 citations

Altered Methylation of Ribosomal RNA in an Erythromycin-Resistant Strain of Staphylococcus aureus

1971 • 274 citations

Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.

1983 • 256 citations

Plasmid-mediated β-lactamases of Gram-negative bacteria: properties and distribution

1979 • 227 citations

Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae

1980 • 224 citations

Emergence of High-Level Trimethoprim Resistance in FecalEscherichia coliduring Oral Administration of Trimethoprim or Trimethoprim-Sulfamethoxazole

1982 • 218 citations

Aminoglycoside uptake and mode of action—with special reference to streptomycin and gentamicin

1981 • 201 citations

MICROBIAL RESISTANCE TO ANTIBIOTICS

1982 • 181 citations

Induction of beta-lactamase by various beta-lactam antibiotics in Enterobacter cloacae

1980 • 177 citations

Mechanism of Aminoglycoside Antibiotic Resistance in Anaerobic Bacteria: Clostridium perfringens and Bacteroides fragilis

1979 • 175 citations

Emergence of Resistance to Cefamandole: Possible Role of Cefoxitin-Inducible Beta-Lactamases

1979 • 174 citations

Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus

1981 • 167 citations

AMPICILLIN-RESISTANT HAEMOPHILUS INFLUENZAE MENINGITIS

1974 • 159 citations

Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism

1982 • 157 citations

Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins

1983 • 154 citations

In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim

1983 • 154 citations

Sensitivity of Group A Streptococci to Antibiotics

1979 • 151 citations

Penicillin-binding proteins of penicillin-susceptible and intrinsically resistant Neisseria gonorrhoeae

1980 • 150 citations

In vitro antagonism of beta-lactam antibiotics by cefoxitin

1982 • 148 citations

Plasmids, drug resistance, and gene transfer in the genus Streptococcus.

1981 • 145 citations

Plasmid-Mediated Beta-Lactamase Production in Neisseria gonorrhoeae

1977 • 137 citations

Gentamicin Uptake in Wild-Type and Aminoglycoside-Resistant Small-Colony Mutants of Staphylococcus aureus

1980 • 129 citations

A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis

1983 • 129 citations

Transferability of macrolide, lincomycin, and streptogramin resistances between group A, B, and D streptococci, Streptococcus pneumoniae, and Staphylococcus aureus

1980 • 128 citations

Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus

1973 • 121 citations

Transferable lincosamide-macrolide resistance in Bacteroides

1979 • 118 citations

R-factor trimethoprim resistance mechanism: An insusceptible target site

1974 • 117 citations

Plasmid-mediated tetracycline resistance in escherichia coli involves increased efflux of the antibiotic

1980 • 113 citations

Microbial Drug Resistance

1955 • 107 citations

In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae

1980 • 100 citations

Binding of beta-lactam antibiotics to penicillin-binding proteins of Staphylococcus aureus and Streptococcus faecalis: relation to antibacterial activity

1980 • 100 citations

Biochemical and genetical approaches to the mechanism of action of penicillin

1980 • 99 citations

beta-Lactam-resistant Pseudomonas aeruginosa with modified penicillin-binding proteins emerging during cystic fibrosis treatment

1981 • 95 citations

Transport of Antibiotics into Bacteria

1982 • 84 citations

Studies on the Mechanism of Intrinsic Resistance to -Lactam Antibiotics in Group D Streptococci

1983 • 82 citations

Gentamicin resistance in clinical-isolates of Pseudomonas aeruginosa associated with diminished gentamicin accumulation and no detectable enzymatic modification.

1976 • 77 citations

In vitro and in vivo antibacterial effects of combinations of beta-lactam antibiotics

1981 • 76 citations

HAEMOPHILUS INFLUENZAE TYPE B RESISTANT TO AMPICILLIN AND CHLORAMPHENICOL IN AN ORPHANAGE IN THAILAND

1980 • 76 citations

R-Factor-Mediated Resistance to Sulfonamides by a Plasmid-Borne, Drug-Resistant Dihydropteroate Synthase

1976 • 76 citations

Plasmid-determined resistance to fosfomycin in Serratia marcescens

1980 • 75 citations

Macrolide Resistance in Staphylococcus aureus : Inducers of Macrolide Resistance

1977 • 72 citations

The Emergence of Bacterial Resistance and Its Influence on Empiric Therapy

1983 • 68 citations

Antimicrobial susceptibility of Streptococcus pneumoniae: serotype distribution of penicillin-resistant strains in Spain

1982 • 67 citations

Principal beta-lactamases responsible for resistance to beta-lactam antibiotics in urinary tract infections

1980 • 65 citations

Mechanisms of resistance to aminoglycosides in clinical isolates

1982 • 64 citations

Relative Inactivation by Staphylococcus aureus of Eight Cephalosporin Antibiotics

1976 • 62 citations

Two Transport Systems for Tetracycline in Sensitive Escherichia coli : Critical Role for an Initial Rapid Uptake System Insensitive to Energy Inhibitors

1978 • 61 citations

Amikacin resistance mediated by multiresistance transposon Tn2424

1983 • 61 citations

Chloramphenicol Resistance in Streptococcus pneumoniae: Enzymatic Acetylation and Possible Plasmid Linkage

1978 • 61 citations

Susceptibility of pneumococci to 14 beta-lactam agents: comparison of strains resistant, intermediate-resistant, and susceptible to penicillin

1981 • 59 citations

Plasmid-determined Fusidic Acid Resistance in the Enterobacteriaceae

1974 • 58 citations

Resistance to Aminoglycosides: Mechanisms and Frequency

1983 • 58 citations

Plasmid-determined β-lactamases identified in a group of 204 ampicillin-resistant Enterobacteriaceae

1983 • 57 citations

Mechanisms of resistance of Escherichia coli to sulfonamides

1963 • 53 citations

Penicillin-binding components of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae

1980 • 50 citations

Diffusion of tetracycline across the outer membrane of Escherichia coli K-12: Involvement of protein Ia

1978 • 49 citations

A Transposon (Tn917) in Streptococcus faecalis That Exhibits Enhanced Transposition during Induction of Drug Resistance

1979 • 47 citations

Human Infections with Thymine-Requiring Bacteria

1978 • 45 citations

Antagonism of carbenicillin and cefamandole by cefoxitin in treatment of experimental infections in mice

1982 • 43 citations

Role of a cefoxitin-inducible beta-lactamase in a case of breakthrough bacteremia

1980 • 43 citations

AMPICILLIN-RESISTANT HÆMOPHILUS INFLUENZÆ MENINGITIS

1974 • 43 citations

Identification of the lethal target of benzylpenicillin in Streptococcus faecalis by in vivo penicillin binding studies

1980 • 43 citations

Inducible and Constitutive Resistance to Macrolide Antibiotics and Lincomycin in Clinically Isolated Strains of Streptococcus pyogenes

1973 • 41 citations

Helper plasmid cloning in Streptococcus sanguis: cloning of a tetracycline resistance determinant from the Streptococcus mutans chromosome

1982 • 40 citations

Inhibition of Folate Metabolism in Chemotherapy

1983 • 38 citations

Dissociated Resistance Among Cephalosporins

1979 • 36 citations

New trends in antibiotics: Research and therapy

1980 • 35 citations

Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens

1982 • 34 citations

Growth of Bacillus subtilis and Spore Germination in Soil Observed by a Fluorescent-antibody Technique

2000 • 34 citations

Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli

1979 • 31 citations

Insensitivity of peptidoglycan biosynthetic reactions to beta-lactam antibiotics in a clinical isolate of Pseudomonas aeruginosa

1981 • 30 citations

Meningitis due to beta lactamase producing type b Haemophilus influenzae resistant to chloramphenicol.

1983 • 26 citations

Drug Resistance of Staphylococci

1967 • 26 citations

Transposons Encoding Trimethoprim or Gentamicin Resistance in Medically Important Bacteria

1981 • 25 citations

Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug

1983 • 25 citations

Mutation of Pseudomonas aeruginosa specifying reduced affinity for penicillin G

1982 • 24 citations

The genetic basis of the spread of β-lactamase synthesis among plasmid-carrying bacteria

1980 • 23 citations

Occurrence of transposable trimethoprim resistance in clinical isolates of Escherichia coli devoid of self-transmissible resistance plasmids

1982 • 22 citations

Tetracycline transport in Bacteroides fragilis

1980 • 22 citations

Resistance to Trimethoprim Among Urinary Tract Isolates in the United Kingdom

1982 • 18 citations

-Lactamases and their clinical significance

1982 • 18 citations

Combination of mezlocillin and azlocillin with cephalosporin antibiotics: cefoxitin, cefoperazone, cefotaxime and moxalactam

1982 • 17 citations

Spread of R-plasmids among Escherichia coli causing urinary tract infections

1981 • 15 citations

Genetic, molecular, and functional analysis of Streptococcus faecalis R plasmid pJH1

1983 • 15 citations

Rifampin and Minocycline in Meningococcal Disease

1983 • 14 citations

Drug Resistance of Staphylococci

1968 • 14 citations

Antibacterial activity of cefoperazone alone and in combination against cephalosporinase-producing Enterobacter cloacae

1983 • 11 citations

Molecular Modifications of Antimicrobial Agents to Overcome Drug Resistance

2015 • 11 citations

Isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae from urinary tract infections

1983 • 9 citations

Gentamicin resistance in Staphylococcus aureus—a new mechanism?

1983 • 4 citations