Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

1986 • 1,148 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE

1977 • 490 citations

Pre- and postsynaptic neurochemical alterations in Alzheimer's disease

1978 • 343 citations

GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE

1980 • 196 citations

CHOLINERGIC APPROACHES TO THE TREATMENT OF ALZHEIMER'S DISEASE

1986 • 159 citations

Acetylcholine and choline levels in post-mortem human brain tissue: Preliminary observations in Alzheimer's disease

1980 • 104 citations

Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives

1990 • 82 citations

Quantitative structure-activity relationship. QSAR, analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase

1992 • 75 citations

Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds

1992 • 65 citations

Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase

1992 • 62 citations

Drug development for senile cognitive decline

1986 • 43 citations

Cyclische Phenyl‐carbamate des Miotin‐Typs und ihre Wirkung auf die Acetylcholinesterase

1990 • 22 citations

Neuropharmacology of degenerative diseases associated with aging

1983 • 8 citations

A modified structure for the acetylcholinesterase receptor

1975 • 5 citations

ChemInform Abstract: The Chemistry of Dementia.

1988 • 2 citations