Single Nucleotide Polymorphism (–468 Gly to Ala) at the Promoter Region of Sterol Regulatory Element-binding Protein-1c Associates with Genetic Defect of Fructose-induced Hepatic Lipogenesis

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

1989 • 1,560 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 • 816 citations

The Deadly Quartet

1989 • 789 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

1999 • 540 citations

Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids

1999 • 486 citations

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

2002 • 415 citations

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

1999 • 327 citations

Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro

1988 • 300 citations

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes

2000 • 256 citations

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene

2000 • 254 citations

Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats

2000 • 239 citations

Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane

1996 • 198 citations

Amelioration of high fructose-induced metabolic derangements by activation of PPARα

2002 • 186 citations

The Role of SREBP-1c in Nutritional Regulation of Lipogenic Enzyme Gene Expression

2002 • 184 citations

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells

1994 • 143 citations

Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level

2000 • 142 citations

Hyperinsulinemia in fructose-induced hypertriglyceridemia in the rat

1980 • 115 citations

Regulation of the Rat SREBP-1c Promoter in Primary Rat Hepatocytes

2002 • 112 citations

Altered Activities of Transcription Factors and Their Related Gene Expression in Cardiac Tissues of Diabetic Rats

1998 • 84 citations

Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.

1995 • 65 citations

Effect of P(i) restriction on renal Na(+)-P(i) cotransporter mRNA and immunoreactive protein in X-linked Hyp mice

1995 • 47 citations

Tissue-specific Regulation of Mouse Core 2 ॆ-1,6-N-Acetylglucosaminyltransferase

1997 • 29 citations

Overexpression of core 2 N‐acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice

1999 • 27 citations

Phylogenetic Development of a Regulatory Gene for the Core 2 GlcNAc Transferase in Mus musculus

2002 • 7 citations