Human immunodeficiency virus 1 reverse transcriptase

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

1985 • 3,185 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

1985 • 1,830 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

1986 • 1,348 citations

A detailed model of reverse transcription and tests of crucial aspects

1979 • 621 citations

Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV

1986 • 543 citations

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

1986 • 483 citations

Mobile Genetic Elements

1983 • 482 citations

Strategies for antiviral therapy in AIDS

1987 • 480 citations

Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions

1985 • 449 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

Site-specific mutagenesis of AIDS virus reverse transcriptase

1987 • 319 citations

Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus

1986 • 308 citations

Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line

1981 • 306 citations

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.

1987 • 232 citations

Primer Requirement and Template Specificity of the DNA Polymerase of RNA Tumor Viruses

1971 • 229 citations

Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants.

1988 • 228 citations

Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates.

1987 • 207 citations

Expression and Processing of the AIDS Virus Reverse Transcriptase in Escherichia coli

1987 • 203 citations

Identification and characterization of HIV-specific RNase H by monoclonal antibody.

1988 • 191 citations

Elementary steps in the DNA polymerase I reaction pathway

1983 • 179 citations

Characterization of the RNA dependent DNA polymerase of a new human T lymphotropic retrovirus (lymphadenopathy associated virus)

1984 • 151 citations

Mechanism of Action of Ribonuclease H Isolated from Avian Myeloblastosis Virus and Escherichia coli

1973 • 136 citations

Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase).

1975 • 123 citations

RNase H activity associated with bacterially expressed reverse transcriptase of human T-cell lymphotropic virus III/lymphadenopathy-associated virus.

1987 • 112 citations

Strand Displacement during Deoxyribonucleic Acid Synthesis at Single Strand Breaks

1971 • 106 citations

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses I. Directing Influence of DNA in the Reaction

1972 • 105 citations

Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis.

1981 • 101 citations

Characterization of strand displacement synthesis catalyzed by bacteriophage T7 DNA polymerase.

1983 • 100 citations

Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeat

1984 • 95 citations

On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase.

1976 • 93 citations

Mechanism of RNA primer removal by the RNase H activity of avian myeloblastosis virus reverse transcriptase

1984 • 77 citations

Absence of Polymerase Protein in Virions of Alpha-Type Rous Sarcoma Virus

1972 • 75 citations

Expression of reverse transcriptase activity of human T-lymphotropic virus type III (HTLV-III/LAV) in Escherichia coli

1986 • 68 citations

Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. II. Evidence for a strand displacement mechanism in plus-strand synthesis

1981 • 66 citations

Enzyme activity gel analysis of human immunodeficiency virus reverse transcriptase.

1988 • 58 citations

Selective oxidation of the exonuclease domain of bacteriophage T7 DNA polymerase.

1987 • 56 citations

Different Mode of Action of Ribonuclease H in Purified α and αβ Ribonucleic Acid-directed Deoxyribonucleic Acid Polymerase from Avian Myeloblastosis Virus

1974 • 56 citations

Interaction of tryptophan tRNA and avian myeloblastosis virus reverse transcriptase: further characterization of the binding reaction

1977 • 54 citations

Mechanism of Carcinogenesis by RNA Tumor Viruses, III Formation of RNA·DNA Complex and Duplex DNA Molecules by the DNA Polymerase(s) of Avian Myeloblastosis Virus

1970 • 53 citations

Characterization of DNA polymerase induced by bacteriophage T5 with DNA containing single strand breaks.

1976 • 49 citations

Unwinding-like activity associated with avian retrovirus RNA-directed DNA polymerase

1978 • 49 citations

Mechanistic Independence of Avian Myeloblastosis Virus DNA Polymerase and Ribonuclease H

1974 • 42 citations

Single-stranded regions on unintegrated avian retrovirus DNA

1982 • 42 citations

Mechanism of action of Moloney murine leukemia virus RNA-directed DNA polymerase associated RNase H (RNase H I)

1981 • 36 citations

Functional Purification and Enzymic Characterization of the RNA-dependent DNA Polymerase of Human Immunodeficiency Virus

1986 • 35 citations

Substrate binding domain of murine leukemia virus reverse transcriptase. Identification of lysine 103 and lysine 421 as binding site residues.

1988 • 31 citations

On the processive mechanism of Escherichia coli DNA polymerase I. Delayed initiation of polymerization.

1976 • 28 citations

Model RNA-directed DNA synthesis by avian myeloblastosis virus DNA polymerase and its associated RNase H

1979 • 24 citations

Mechanism of primer-template-dependent conversion of dNTP leads to dNMP by T5 DNA polymerase.

1980 • 21 citations

Processive nature of reverse transcription by avian myeloblastosis virus deoxyribonucleic acid polymerase

1980 • 14 citations

Misincorporation by AMV reverse transcriptase shows strong dependence on the combination of template and substrate nucleotides

1986 • 8 citations

Duplex DNA binding activity of the avian myeloblastosis virus DNA polymerase

1981 • 4 citations