Extrinsic protein stabilization by the naturally occurring osmolytes β-hydroxyectoine and betaine

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures

1981 • 1,170 citations

The stabilization of proteins by sucrose.

1981 • 1,084 citations

Energetics of Protein Structure

1995 • 1,040 citations

Protein stability curves

1987 • 990 citations

The stabilization of proteins by osmolytes

1985 • 984 citations

Heat capacity of proteins

1990 • 511 citations

Contribution of Hydration to Protein Folding Thermodynamics

1993 • 474 citations

The Peptide Backbone Plays a Dominant Role in Protein Stabilization by Naturally Occurring Osmolytes

1995 • 450 citations

NMR Determination of Residual Structure in a Urea-Denatured Protein, the 434-Repressor

1992 • 449 citations

Increased thermal stability of proteins in the presence of naturally occurring osmolytes

1992 • 437 citations

Common Features of Protein Unfolding and Dissolution of Hydrophobic Compounds

1990 • 435 citations

Osmoadaptation in Bacteria

1995 • 425 citations

The role of trehalose synthesis for the acquisition of thermotolerance in yeast

1994 • 379 citations

Thermodynamics of the denaturation of lysozyme in alcohol-water mixtures

1979 • 204 citations

Thermoadaptation of methanogenic bacteria by intracellular ion concentration

1988 • 201 citations

Denatured states of ribonuclease A have compact dimensions and residual secondary structure

1992 • 157 citations

Hydration effects in protein unfolding

1994 • 124 citations

A Physicochemical Basis for the Selection of Osmolytes by Nature

1992 • 107 citations

New compatible solutes related to Di-myo-inositol-phosphate in members of the order Thermotogales

1996 • 102 citations

Effects of a Naturally Occurring Compatible Osmolyte on the Internal Dynamics of Ribonuclease A

1995 • 96 citations

Equilibrium folding pathway of staphylococcal nuclease: identification of the most stable chain-chain interactions by NMR and CD spectroscopy

1995 • 93 citations

Induction of synthesis of tetrahydropyrimidine derivatives in Streptomyces strains and their effect on Escherichia coli in response to osmotic and heat stress

1996 • 80 citations

An osmolyte effect on the heat capacity change for protein folding

1995 • 73 citations

The Observed Change in Heat Capacity Accompanying the Thermal Unfolding of Proteins Depends on the Composition of the Solution and on the Method Employed To Change the Temperature of Unfolding

1996 • 65 citations

On the origin of the enthalpy and entropy convergence temperatures in protein folding.

1992 • 64 citations

Production of hydroxyectoine: high cell-density cultivation and osmotic downshock of Marinococcus strain M52

1995 • 49 citations