CD8+ T cell activation correlates with disease activity in clinically isolated syndromes and is regulated by interferon-β treatment

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1983 • 14,011 citations

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

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Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

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IMMUNOLOGY OF MULTIPLE SCLEROSIS

2005 • 2,099 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

2000 • 918 citations

Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation

2000 • 889 citations

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time

2002 • 766 citations

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

2001 • 650 citations

Human cerebrospinal fluid central memory CD4⁺T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin

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Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases

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The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

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CD69 is an immunoregulatory molecule induced following activation

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Loss of Suppressor T Cells in Active Multiple Sclerosis

1980 • 446 citations

Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice

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Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions

1986 • 383 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Role of CD8 ⁺ T Cells in Murine Experimental Allergic Encephalomyelitis

1992 • 351 citations

Multiple sclerosis: Brain-infiltrating CD8⁺T cells persist as clonal expansions in the cerebrospinal fluid and blood

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The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion

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Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content.

1983 • 326 citations

Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis

1983 • 287 citations

Transection of Major Histocompatibility Complex Class I-Induced Neurites by Cytotoxic T Lymphocytes

2001 • 265 citations

Expression of CCR7 in multiple sclerosis: Implications for CNS immunity

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High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay

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Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity

1979 • 251 citations

Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients

2002 • 246 citations

Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes

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Expression of Major Histocompatibility Complex class l Molecules on the Different Cell Types in Multiple Sclerosis Lesions

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In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis

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Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.

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Vulnerability of Human Neurons to T Cell-Mediated Cytotoxicity

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DEFICIT OF SUPPRESSOR T CELLS IN ACTIVE MULTIPLE SCLEROSIS

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CD8⁺CD28⁻ T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity

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Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis

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CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO

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CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1

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MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes

1998 • 162 citations

Genes in the HLA class I region may contribute to the HLA class II‐associated genetic susceptibility to multiple sclerosis

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Qa-1 restriction of CD8+ suppressor T cells

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Increased CD8+ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis

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Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling

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Interfer beta augments supperssor cell function in multiple sclerosis

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Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro.

1992 • 118 citations

Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.

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Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients

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Immunomodulatory effects of interferon beta-1a in multiple sclerosis

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Interferon-? secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-? therapy

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Homeostatic control of immunity by TCR peptide–specific Tregs

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Antigen reactive memory T cells are defined by Ta1.

1986 • 91 citations

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients

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Suppressor T‐lymphocytes in multiple sclerosis: Analysis of patients with acute relapsing and chronic progressive disease

1983 • 76 citations

Interferon-β treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-γ and interleukin-4

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Defective production of anti-inflammatory cytokine, TGF-beta by T cell lines of patients with active multiple sclerosis.

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Distinct chemokine receptor and cytokine expression profile in secondary progressive MS

2001 • 73 citations

Single-cell analysis of cytokine production shows different immune profiles in multiple sclerosis patients with active or quiescent disease

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Disease activity markers in multiple sclerosis Another look at suppressor cells defined by monoclonal antibodies OKT4, OKT5, and OKT8

1984 • 59 citations

Blood T-cell receptor chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution

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Interferon β-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis

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Reduction of both pro- and anti-inflammatory cytokines after 6 months of interferon beta-1a treatment of multiple sclerosis

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Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression.

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CD4 T cell activation and disease activity at onset of multiple sclerosis

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Analysis of T regulator cell surface markers and functional properties in multiple sclerosis

1984 • 41 citations

Increased T cell expression of CD154 (CD40‐ligand) in multiple sclerosis

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Cytokine producing CD8+ T cells are correlated to MRI features of tissue destruction in MS

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Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis

2002 • 36 citations

Interferon gamma and interleukin 4 producing T cells in peripheral blood of multiple sclerosis patients undergoing immunomodulatory treatment

2002 • 35 citations

Transferrin receptor in T cell activation and transplantation

1998 • 34 citations

Human CD8+ TCR-αβ+ and TCR-γδ+ cells modulate autologous autoreactive neuroantigen-specific CD4+ T-cells by different mechanisms

1997 • 33 citations

Lymphocyte subsets in multiple sclerosis A study with two-colour fluorescence analysis

1996 • 30 citations

Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin

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Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS

2004 • 17 citations

Immunomodulatory effects of interferon-β-1b in patients with multiple sclerosis

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CD8+ high CD11b+ low T cells (T suppressor-effectors) in multiple sclerosis cerebrospinal fluid are increased during high dose corticosteroid treatment

1991 • 14 citations

Lymphocyte subsets in multiple sclerosis A study with two-colour fluorescence analysis

1996 • 7 citations

Augmentation by transferrin of IL-2-inducible killer activity and perform production of human CD8+ T cells

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Evidence favoring the involvement of CC chemokine receptor (CCR) 5 in T-lymphocyte accumulation in optic neuritis

2003 • 6 citations

T-cell subpopulations in the cerebrospinal fluid and peripheral blood of patients with multiple sclerosis

1996 • 5 citations