Calcium channel blockers in cerebral ischaemia

Arzneimittelforschung

2005 • 8,820 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

Calcium antagonism and calcium entry blockade.

1986 • 1,201 citations

Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.

1989 • 1,087 citations

Islam and Liberal Democracy: A Historical Overview

1996 • 658 citations

Historical Overview

1988 • 428 citations

A Controlled Trial of Nimodipine in Acute Ischemic Stroke

1988 • 423 citations

Nimodipine Improves Cerebral Blood Flow and Neurologic Recovery after Complete Cerebral Ischemia in the Dog

1983 • 347 citations

Primary Structure of the γ Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1990 • 263 citations

Nimodipine Improves Outcome when Given after Complete Cerebral Ischemia in Primates

1985 • 256 citations

Ca²⁺ channel ligands: Structure‐function relationships of the 1,4‐dihydropyridines

1989 • 252 citations

A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia.

1993 • 250 citations

Neuroregulatory and Neuropathological Actions of the Ether-Phospholipid Platelet-Activating Factor

1988 • 243 citations

Clinical trial of nimodipine in acute ischemic stroke. The American Nimodipine Study Group.

1992 • 233 citations

Molecular determinants of Ca2+ channel function and drug action

1995 • 198 citations

Cerebral Blood Flow and Neurologic Outcome When Nimodipine is Given after Complete Cerebral Ischemia in the Dog

1984 • 177 citations

Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons.

1996 • 162 citations

The therapeutic value of nimodipine in experimental focal cerebral ischemia

1987 • 146 citations

Selective neuronal vulnerability following transient cerebral ischemia in the gerbil: distribution and time course

1989 • 143 citations

Randomised, double-blind, placebo-controlled trial of nimodipine in acute stroke

1990 • 141 citations

Calcium antagonists reduce the extent of infarction in rat middle cerebral artery occlusion model as determined by quantitative magnetic resonance imaging.

1986 • 140 citations

Functional Diversity of P-Type and R-Type Calcium Channels in Rat Cerebellar Neurons

1996 • 140 citations

(S)‐Emopamil, a novel calcium channel blocker and serotonin S ₂ antagonist, markedly reduces infarct size following middle cerebral artery occlusion in the rat

1988 • 139 citations

Interaction of SNARE Complexes with P/Q-type Calcium Channels in Rat Cerebellar Synaptosomes

1996 • 138 citations

Role of calcium channel subtypes in calcium transients in hippocampal CA3 neurons

1995 • 115 citations

Comparative protective effects of nicardipine, flunarizine, lidoflazine and nimodipine against ischaemic injury in the hippocampus of the Mongolian gerbil

1988 • 114 citations

Effect of nimodipine on intracellular brain pH, cortical blood flow, and EEG in experimental focal cerebral ischemia

1986 • 113 citations

Placebo-controlled trial of nimodipine in the treatment of acute ischemic cerebral infarction.

1990 • 111 citations

Isoproterenol potentiates synaptic transmission primarily by enhancing presynaptic calcium influx via P- and/or Q-type calcium channels in the rat amygdala

1996 • 111 citations

Selective N-Type Calcium Channel Antagonist Omega Conotoxin MVIIA Is Neuroprotective Against Hypoxic Neurodegeneration in Organotypic Hippocampal-Slice Cultures

1996 • 100 citations

Continuous Nimodipine Treatment Attenuates Cortical Infarction in Rats Subjected to 24 Hours of Focal Cerebral Ischemia

1990 • 97 citations

Failure of nimodipine to prevent ischemic neuronal damage in rats.

1987 • 95 citations

Production of Platelet‐Activating Factor from Rat Cerebellar Granule Cells in Culture

1990 • 92 citations

Flunarizine in stroke treatment (FIST): a double-blind, placebo-controlled trial in Scandinavia and the Netherlands

2009 • 88 citations

Nimodipine in acute ischemic stroke: a double-blind controlled study

1989 • 77 citations

Double-Blind Study of Nimodipine in Non-Severe Stroke

1990 • 71 citations

N-type Ca2+ Channels Are Present in Secretory Granules and Are Transiently Translocated to the Plasma Membrane during Regulated Exocytosis

1996 • 63 citations

Hyperglycemia augments ischemic brain injury: in vivo MR imaging/spectroscopic study with nicardipine in cats with occluded middle cerebral arteries.

1991 • 61 citations

Effects of Calcium on Excitable Membranes and Neurotransmitter Action

1972 • 60 citations

Role of the excitotoxic mechanism in the development of neuronal damage following repeated brief cerebral ischemia in the gerbil: protective effects of MK-801 and pentobarbital

1990 • 58 citations

Effects of a New Calcium Channel Blocker, KB‐2796, on Protein Synthesis of the CA1 Pyramidal Cell and Delayed Neuronal Death Following Transient Forebrain Ischemia

1989 • 55 citations

New Uses for Calcium Channel Blockers

1993 • 54 citations

SB 201823-A, a neuronal Ca2+ antagonist is neuroprotective in two models of cerebral ischaemia

1993 • 53 citations

Block of P/Q-Type Calcium Channels by Therapeutic Concentrations of Aminoglycoside Antibiotics

1996 • 53 citations

Neuronal protective effects of calcium antagonists in cerebral ischemia

1994 • 52 citations

Characterization of cDNA clones encoding two putative isoforms of the α₁ subunit of the dihydropyridine-sensitive voltage-dependent calcium channel isolated from rat brain and rat aorta

1989 • 51 citations

Combination therapy with nimodipine and dizocilpine in a rat model of transient forebrain ischemia.

1992 • 48 citations

The effect of the calcium antagonist nimodipine on the gerbil model of experimental cerebral ischemia.

1986 • 48 citations

Calcium channels in cerebral arteries

1995 • 48 citations

SB 201823-A Antagonizes Calcium Currents in Central Neurons and Reduces the Effects of Focal Ischemia in Rats and Mice

1995 • 47 citations

Reduction of Infarct Size by Intra-Arterial Nimodipine Administered at Reperfusion in a Rat Model of Partially Reversible Brain Focal Ischemia

1995 • 47 citations

Relationship between putrescine content and density of ischemic cell damage in the brain of mongolian gerbils: effect of nimodipine and barbiturate

1988 • 47 citations

Inhibition of neuronal Ca2+ channel currents by the funnel web spider toxin omega-Aga-IA.

1990 • 46 citations

Flunarizine in Acute Ischemic Stroke: A Pilot Study

1990 • 45 citations

Direct evidence for calcium‐induced ischemic and reperfusion injury

1989 • 44 citations

The solution structure of ?-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta

1995 • 44 citations

Diffusion- and T2-weighted imaging: Evaluation of oedema reduction in focal cerebral ischaemia by the calcium and serotonin antagonist levemopamil

1993 • 44 citations

Neuroprotective properties of calcium-channel blockers.

1996 • 44 citations

Flunarizine, a Calcium Channel Antagonist, Is Partially Prophylactically Neuroprotective in Hypoxic-Ischemic Encephalopathy in the Fetal Sheep

1994 • 42 citations

Behavioural and anticonvulsant effects of Ca2+ channel toxins in DBA/2 mice

1996 • 42 citations

Functional, Behavioral, and Histological Changes Induced by Transient Global Cerebral Ischemia in Rats: Effects of Cinnarizine and Flunarizine

1989 • 41 citations

Inhibition of Ischemia‐Induced Dopamine Release by ω‐Conotoxin, a Calcium Channel Blocker, in the Striatum of Spontaneously Hypertensive Rats: In Vivo Brain Dialysis Study

1992 • 40 citations

Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia

1994 • 39 citations

ω-conotoxin GVIA protects against ischemia-induced neuronal death in the Mongolian gerbil but not against quinolinic acid-induced neurotoxicity in the rat

1994 • 38 citations

Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats.

1991 • 37 citations

(S)-emopamil protects against global ischemic brain injury in rats.

1990 • 37 citations

Effect of S-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits.

1993 • 35 citations

Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats.

1991 • 33 citations

Comparative neuroprotective effects of pentobarbital, vinpocetine, flunarizine and ifenprodil on ischemic neuronal damage in the gerbil hippocampus

1990 • 32 citations

Effects of nimodipine on infarct size and cerebral acidosis after middle cerebral artery occlusion in the rat.

1990 • 32 citations

The efficacy of intravenous nimodipine in the treatment of focal cerebral ischemia in a primate model

1989 • 31 citations

Effects of Calcium Entry Blocker Emopamil on Postischemic Energy Metabolism of the Isolated Perfused Rat Brain

1987 • 27 citations

Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638.

1995 • 26 citations

The Efficacy of Intravenous Nimodipine in the Treatment of Focal Cerebral Ischemia in a Primate Model

1989 • 25 citations

Magnetic resonance imaging study on the effect of levemopamil on the size of intracerebral hemorrhage in rats.

1994 • 25 citations

(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile.

1989 • 24 citations

Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats

1991 • 22 citations

Isradipine, a calcium channel blocker, attenuates the ischemia-induced release of dopamine but not glutamate in rats

1995 • 21 citations

Failure of Isradipine to Reduce Infarct Size in Mouse, Gerbil, and Rat Models of Cerebral Ischemia

1995 • 21 citations

Prevention of Stroke and Brain Damage With Calcium Antagonists in Animals

1991 • 20 citations

Pharmacological profile and anti-ischemic properties of the Ca2+-channel blocker NS-638

1995 • 20 citations

Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats.

1991 • 18 citations

Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats

1991 • 18 citations

Effects of levemopamil on neurologic and histologic outcome after cardiac arrest in cats

1992 • 16 citations

Possible Neuroprotective Properties of Flunarizine Infused after Asphyxia in Fetal Lambs Are Not Explained by Effects on Cerebral Blood Flow or Systemic Blood Pressure

1993 • 15 citations

Therapeutic effects of nilvadipine on rat focal cerebral ischemia

1994 • 12 citations

The Effect of Nimodipine on High-Energy Phosphates and Intracellular pH During Cerebral Ischemia

1993 • 12 citations

Spatial distribution of ω‐agatoxin IVA binding sites in mouse brain slices

1995 • 12 citations

Effect of calcium antagonists on postischemic protein biosynthesis in gerbil brain.

1992 • 11 citations

The Novel Dihydronaphthyridine Ca²⁺ Channel Blocker CI-951 Improves CBF, Brain pH_i, and EEG Recovery in Focal Cerebral Ischemia

1990 • 11 citations

Lack of effect of PN 200-110 on neuronal injury and neurological outcome in middle cerebral artery-occluded rats.

1991 • 11 citations

Failure of levemopamil to improve histological outcome following temporary occlusion of the middle cerebral artery in cats

1995 • 10 citations

Flunarizine, a Calcium Channel Antagonist, Is Not Neuroprotective when Given after Hypoxia-Ischemia in the Infant Rat

1991 • 10 citations

Effects of nilvadipine on neuronal function in the ischemic cat brain

1992 • 9 citations

Nimodipine has no beneficial effect on neurological outcome in a cardiopulmonary arrest model in the rat

1990 • 9 citations

Effect of nicardipine on somatosensory evoked potentials in patients with acute cerebral infarction.

1990 • 9 citations

Attenuation of ischemic and postischemic damage to brain metabolism and circulation by a novel Ca2+ channel antagonist, NC-1100, in spontaneously hypertensive rats

1992 • 8 citations

Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus

1992 • 8 citations

Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats

1994 • 8 citations

Physiological Results of Monkey Brain Ischemia, and Protection by a Calcium Blocker

1995 • 7 citations

Cerebral protective effect of flunarizine in a canine model of cerebral ischaemia

1988 • 7 citations

Effect of a New Calcium Entry Blocker, NB-818, on Delayed Neuronal Death in the Ischemic Gerbil Hippocampus.

1991 • 6 citations

The effect of Ca2+ channel antagonists (cadmium, ω-conotoxin GIVA, and nitrendipine) on the release of angiotensin II from fetal rat brain in vitro

1991 • 6 citations

Modulation of ischemic-induced damage to cerebral adenylate cyclase in gerbils by calcium channel blockers

1986 • 5 citations

Protective Effect of Nilvadipine on Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

1996 • 4 citations

Effects of nimodipine on multiunit activity of several brain structures following acute global cerebral ischemia-anoxia in cats.

1992 • 4 citations

Effects of Nimodipine on Brain Blood Flow following Acute Brain Ischemia in the Newborn Piglet

1992 • 4 citations

Deleted Work

1955 • 0 citations