Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: A review

Some Studies of the Protein-Binding of Steroids and Their Application to the Routine Micro and Ultramicro Measurement of Various Steroids in Body Fluids by Competitive Protein-Binding Radioassay¹

1967 • 2,022 citations

Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics

1976 • 375 citations

PREDNISONE SIDE-EFFECTS AND SERUM-PROTEIN LEVELS

1971 • 240 citations

CHANGES IN CORTISOL METABOLISM FOLLOWING RIFAMPICIN THERAPY

1974 • 211 citations

Adverse Effects of Phenobarbital on Corticosteroid Metabolism in Patients with Bronchial Asthma

1972 • 186 citations

Clinical Pharmacokinetics of Prednisone and Prednisolone

1979 • 173 citations

CARDIOVASCULAR-DISEASE MORTALITY TRENDS AND ORAL-CONTRACEPTIVE USE IN YOUNG WOMEN

1976 • 172 citations

Effect of Diphenylhydantoin on Cortisol Metabolism in Man *

1964 • 169 citations

Corticosteroid analysis in biological fluids by high-performance liquid chromatography

1979 • 162 citations

Studies on Dexamethasone Metabolism in Man: Effect of Diphenylhydantoin

1972 • 145 citations

Decreased Clearance of Prednisolone, a Factor in the Development of Corticosteroid Side Effects

1974 • 143 citations

Corticosteroids in liver disease: Studies on the biological conversion of prednisone to prednisolone and plasma protein binding

1972 • 136 citations

Effect of Diphenylhydantoin on the Metabolism of Dexamethasone

1970 • 135 citations

Conversion of cortisone to cortisol and prednisone to prednisolone.

1967 • 133 citations

Decreased Bioavailability of Digoxin Due to Antacids and Kaolin-Pectin

1976 • 125 citations

Patterns of plasma concentrations and urinary excretion of salicylate in rheumatoid arthritis

1977 • 108 citations

Interaction of rifampin and glucocorticoids. Adverse effect on renal allograft function.

1976 • 101 citations

Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma.

1979 • 101 citations

METABOLISM OF FREE AND CONJUGATED 17-HYDROXYCORTICOSTEROIDS IN SUBJECTS WITH UREMIA*

1958 • 93 citations

INTRAVENOUS CORTICOSTEROIDS IN TREATMENT OF ACUTE BRONCHIAL ASTHMA

1970 • 91 citations

Effect of Corticosteroids on Blood Salicylate Concentration

1965 • 91 citations

Kinetics and Interconversion of Prednisolone and Prednisone Studied with New Radioimmunoassays

1975 • 87 citations

Interaction of Rifampin and Glucocorticoids

1976 • 78 citations

ULTRAFILTRATION STUDIES OF STEROID-PROTEIN BINDING

1961 • 76 citations

Prednisone for Chronic Active Liver Disease: Pharmacokinetics, Including Conversion to Prednisolone

1977 • 76 citations

Dose dependent pharmacokinetics of prednisolone

1977 • 75 citations

Prednisone or prednisolone for the treatment of chronic active hepatitis? A comparison of plasma availability.

1978 • 74 citations

Diurnal variation of prednisolone binding to serum corticosteroid‐binding globulin in man

1978 • 73 citations

Dose‐dependent prednisolone kinetics

1979 • 72 citations

Radioimmunoassay for prednisolone

1973 • 72 citations

Effectiveness of prednisolone during phenytoin therapy

1977 • 69 citations

Inactive Prednisone Tablets U.S.P. XVI

1963 • 68 citations

Quantitative determination of cortisol in human plasma by high-pressure liquid chromatography

1975 • 65 citations

Pharmacokinetic studies of prednisolone in children

1978 • 65 citations

Effects of Diphenylhydantoin, Phenobarbital, and Diazepam on the Metabolism of Methylprednisolone and Its Sodium Succinate

1975 • 64 citations

Effect of diphenylhydantoin on cortisol kinetics in humans.

1971 • 64 citations

Oral prednisone for chronic active liver disease: dose responses and bioavailability studies.

1978 • 61 citations

Rejection Crises in Human Renal Transplant Recipients

1972 • 58 citations

Prednisolone Disposition in Cushingoid and Noncushingoid Kidney Transplant Patients*

1980 • 54 citations

Determination of serum cortisol and 11-deoxycortisol by liquid chromatography.

1979 • 53 citations

Disappearance rates and immunosuppression of intermittent intravenously administered prednisolone in rabbits and human beings.

1970 • 53 citations

Variation in plasma prednisolone concentrations in renal transplant recipients given enteric-coated prednisolone.

1979 • 53 citations

URINARY METABOLIC PRODUCTS OF PREDNISONE AND PREDNISOLONE

1956 • 52 citations

THE METABOLISM OF 4-14C PREDNISOLONE

1959 • 49 citations

Improved liquid-chromatographic method for determination of serum cortisol.

1979 • 49 citations

Rifampicin-induced non-responsiveness to corticosteroid treatment in nephrotic syndrome.

1979 • 48 citations

Pulmonary Disease and Drug Kinetics

1978 • 48 citations

A STUDY OF CORTISOL METABOLISM IN PATIENTS WITH CHRONIC ASTHMA

1967 • 48 citations

The adverse effect of anticonvulsant therapy on renal allograft survival

1976 • 46 citations

Analysis of prednisolone in plasma by high-performance liquid chromatography

1977 • 44 citations

DIFFERENCES IN METABOLISM OF PREDNISOLONE-C¹⁴AND CORTISOL-C¹⁴

1957 • 44 citations

Effect of steroid hormone on activation of endoxan (cyclophosphamide)

1969 • 44 citations

Quantitation of dexamethasone in biological fluids using high-performance liquid chromatography

1978 • 44 citations

Plasma prednisolone levels from enteric and non‐enteric coated tablets estimated by an original technique.

1977 • 44 citations

Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study.

1976 • 42 citations

In Vitro andIn Vivo availability of some commercial prednisolone tablets

1974 • 41 citations

Bioavailability and pharmacokinetics of prednisone in humans

1975 • 39 citations

In Vitro and In Vivo Availability of Commercial Prednisone Tablets

1975 • 38 citations

A COMPARATIVE STUDY OF THE METABOLISM OF HYDROCORTISONE AND PREDNISOLONE*

1959 • 38 citations

Value of monitoring plasma salicylate levels in treating juvenile rheumatoid arthritis. Observations in 42 cases.

1978 • 36 citations

Studies on Inactive Prednisone Tablets, U.S.P. XVI

1964 • 36 citations

Comparative bioavailability: Eight commercial prednisone tablets

1976 • 36 citations

Dose-dependent pharmacokinetics of prednisone and prednisolone in man

1978 • 35 citations

Bioavailability of prednisolone tablets

1977 • 34 citations

Measurement of plasma prednisolone in man.

1975 • 34 citations

Corticosteroid Pharmacokinetics in Liver Disease

1979 • 33 citations

Absorption of enteric and non‐enteric coated prednisolone tablets.

1975 • 33 citations

Patterns of plasma levels of prednisolone after oral administration in man

1974 • 33 citations

High-performance liquid chromatographic analysis for synthetic corticosteroids in plasma

1977 • 32 citations

Prednisolone levels in the plasma and urine: a study of two preparations in man.

1975 • 32 citations

Allograft survival in patients receiving anticonvulsant medications.

1977 • 31 citations

Dynamics of Synthetic Corticosteroids in Man

1966 • 31 citations

Measurement of plasma prednisolone by a competitive protein-binding assay

1970 • 29 citations

Sustained-Release Formulation of Prednisolone Administered Orally to Man

1971 • 29 citations

The Effects of Some Solid Buffering Agents in Aqueous Suspension on Prednisolone**Upjohn Company, Kalamazoo, Mich.

1958 • 29 citations

Concurrent administration of antacids and prednisone: effect on serum levels of prednisolone.

1979 • 29 citations

Simultaneous Competitive Protein Binding Assay for Cortisol, Cortisone, and Prednisolone in Plasma, and Its Clinical Application

1973 • 28 citations

1-Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations Following Oral and I. V. Administration.

1956 • 27 citations

A radioimmunoassay method for prednisolone: comparison with the competitive protein binding method.

1976 • 27 citations

Effect of Hemodialysis on Methylprednisolone Plasma Levels

1977 • 25 citations

Quantitative Determination of Prednisone and Prednisolone in Human Plasma Using GLC and Chemical-Ionization Mass Spectrometry

1978 • 25 citations

THE METABOLISM OF 1-DEHYDRO-17-HYDROXYCORTICOSTEROIDS IN HUMAN SUBJECTS

1957 • 23 citations

Effect of Liquid Diet on Serum Protein Binding and Prednisolone Concentrations After Oral Prednisone

1976 • 23 citations

Measurement of plasma prednisolone by gas chromatography.

1969 • 20 citations

Radioimmunoassay for prednisone

1974 • 18 citations

Effect of Food on the Bioavailability of Prednisone

1976 • 18 citations

A Competitive Protein Binding Method for Plasma Prednisolone Assay

1974 • 18 citations

Plasma levels and urinary excretion of [14C]eyclophosphanude and its radioactive metabolites in rats pretreated with prednisolone

1972 • 18 citations

Use of high-pressure liquid chromatography in the assay of aldosterone in urine

1977 • 13 citations

Development of radioimmunoassays for prednisone and prednisolone. Application to studies of hepatic metabolism of prednisone.

1976 • 13 citations

Studies on the episodic secretion of cortisol in uremic patients on hemodialysis.

1972 • 12 citations

Changes of plasma concentration and elimination of various hormones by haemofiltration.

1977 • 10 citations

Methylprednisolone blood levels in cadaveric renal allograft recipients.

1978 • 9 citations

Mercurochrome as a Histological Stain

1926 • 9 citations

Influence of sodium taurocholate, cholestyramine, and mylanta on the intestinal absorption of glucocorticoids in the rat.

1973 • 8 citations

Statistical survey of “saturation analysis” calibration curve data for prednisolone, prednisone and digoxin

1976 • 8 citations

Determination of methylprednisolone and hydrocortisone in plasma using high pressure liquid chromatography.

1977 • 8 citations

Nomogram for prednisone-prednisolone adjustment dose in patients with hypoalbuminemia.

1978 • 7 citations

DOSE DEPENDENT PHARMACOKINETICS OF PREDNISOLONE IN MAN

1978 • 7 citations

Commentary: Anticonvulsant therapy and renal allograft survival

1976 • 7 citations

The excretion of metabolites of cortisol and aldosterone in male patients on haemodialysis treatment

1977 • 6 citations

Influence of Sodium Taurocholate, Cholestyramine, and Mylanta on the Intestinal Absorption of Glucocorticoids in the Rat

1973 • 5 citations

Disappearance of high dose prednisolone from plasma after renal transplantation.

1974 • 5 citations

[Influence of aluminium- and magnesium hydroxide (Alucol) on cortisone absorption].

1973 • 5 citations

Protein-binding and metabolic clearance of cortisol in asthmatic patients.

1974 • 4 citations

Specific assays for prednisolone and prednisone in serum: Lipidex chromatography followed by radioimmunoassay

1978 • 4 citations

Prednisolone

1976 • 3 citations

[Catabolism and excretion of 4-14C-cortisol following bilateral nephrectomy].

1967 • 2 citations

Actions of prednisolone acetate, pregnenolone-16α-carbonitrile, and triamcinolone upon drug resistance and metabolism: a comparative study

1977 • 2 citations

A Simple Method for Separate Determination of Delta4- and Delta1,4-Corticosteroids in Urine

1971 • 2 citations