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1977 • 835 citations

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1984 • 719 citations

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

1987 • 611 citations

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1980 • 609 citations

Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain

1981 • 524 citations

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1979 • 316 citations

Evidence that locus coeruleus is the site where clonidine and drugs acting at α₁‐ and α₂‐adrenoceptors affect sleep and arousal mechanisms

1987 • 244 citations

Central α1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals

1990 • 221 citations

Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus coeruleus in the progression of Parkinson's disease

1991 • 211 citations

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 185 citations

The distribution of neocortical projection neurons in the locus coeruleus

1983 • 179 citations

Pharmacological evidence for a stimulation of dopamine neurons by noradrenaline neurons in the brain

1976 • 179 citations

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1987 • 166 citations

Injection of 6-hydroxydopamine into the substantia nigra of the rat. II. Diffusion and specificity

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Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant actions ofd-amphetamine and apomorphine

1988 • 140 citations

Clonidine modulates dopamine cell firing in rat ventral tegmental area

1989 • 126 citations

Evidence that apomorphine and pergolide induce rotation in rats by different actions on D1 and D2 receptor sites

1984 • 124 citations

Effects of locus coeruleus lesions on the release of endogenous dopamine in the rat nucleus accumbens and caudate nucleus as determined by intracerebral microdialysis

1990 • 120 citations

α1- and α2-Adrenoreceptor antagonists differentially influence locomotor and stereotyped behaviour induced byd-amphetamine and apomorphine in the rat

1988 • 110 citations

A lipophilic, selective α1 -adrenoceptor agonist: 2-(2-chloro-5-trifluoromethylphenylimino) imidazolidine (St 587)

1981 • 104 citations

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1979 • 80 citations

Phenylephrine-induced activity in mice as a model of central α1-adrenoceptor functionEffects of acute and repeated administration of antidepressant drugs and electroconvulsive shock

1984 • 79 citations

The relative importance of dopamine and norepinephrine in mediating locomotor activity

1983 • 74 citations

The roles of noradrenaline and dopamine in contraversive circling behaviour seen after unilateral electrolytic lesions of the locus coeruleus

1976 • 67 citations

Interactions of D1 and D2 dopamine receptors on the ipsilateral vs. contralateral side in rats with unilateral lesions of the dopaminergic nigrostriatal pathway.

1988 • 62 citations

Clonidine regularizes substantia nigra dopamine cell firing

1988 • 60 citations

Effects of idazoxan on catecholamine systems in rat brain

1984 • 54 citations

Lack of involvement of α2-adrenoceptors in the regulation of striatal dopaminergic transmission

1983 • 52 citations

Topography of dopamine behaviours mediated by D1 and D2 receptors revealed by intrastriatal injection of SKF 38393, lisuride and apomorphine in rats with a unilateral 6-hydroxydopamine-induced lesion

1987 • 50 citations

DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment

1990 • 48 citations

Neurochemical and electrophysiological evidence for a projection from the locus coeruleus to the substantia nigra [proceedings].

1979 • 45 citations

Specific D1 and D2 dopamine agonists have synergistic effects in the 6-hydroxydopamine circling model in the rat

1988 • 45 citations

?2 and ?-adrenoceptor agonists modulate [3H]dopamine release from rat nucleus accumbens slices: Implications for research into depression

1984 • 43 citations

Evidence for existence of two opposite noradrenergic brain systems controlling behavior

1978 • 34 citations

Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats

1977 • 33 citations

Effects of clonidine, piperoxane and locus coeruleus lesion on the serotonergic and dopaminergic systems in raphe and caudate nucleus

1984 • 33 citations

Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: Competition studies with [3H]prazosin and [3H]idazoxan

1987 • 28 citations

The interaction of clonidine with dopamine-dependent behaviour in rodents

1977 • 27 citations

Does contralateral circling involve action of drugs on hyposensitive striatal dopamine receptors in the hemisphere contralateral to denervation?

1983 • 21 citations

Neurochemical and behavioral effects of clonidine and related imidazolines: Interaction with α-adrenoceptors

1978 • 20 citations

Norepinephrine Stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine

1989 • 19 citations

α2-Adrenergic Sensitivity in Parkinsonʼs Disease

1989 • 19 citations

Specific α2-adrenoreceptor antagonists induce behavioural activation in the rat

1990 • 17 citations

Amphetamine-induced rotation reveals post 6-OHDA lesion neurochemical reorganization

1989 • 15 citations

Different patterns of rotational behavior in rats after dorsal or ventral striatal lesions with ibotenic acid

1988 • 14 citations

Lethality of opioid and antihistaminic combinations in mice

1985 • 12 citations

Clonidine sensitizes mice for apomorphine-induced stereotypic gnawing: Antagonism by neuroleptics and cholecystokinin-like peptides

1985 • 11 citations

Possible role of alpha-2 and alpha-1 adrenoceptors in the experimentally-induced depression of the central nervous system

1989 • 11 citations

Modulation of the behavioral effects of amphetamine in rats by clonidine

1982 • 10 citations

Behavioural and biochemical effects of chronic reduction of cerebral noradrenaline receptor stimulation

1977 • 10 citations

Alpha2-adrenergic antagonists effect on amphetamine-induced behaviors

1986 • 7 citations

Rotational behavior produced by unilateral ventral noradrenergic bundle lesions: Evidence for a noradrenergic-dopaminergic interaction in the brain

1982 • 7 citations

Conditioned circling in rats: Bilateral involvement of the mesotelencephalic dopamine system demonstrated following unilateral 6-hydroxydopamine lesions

1988 • 7 citations

Pimozide blocks the open-field hyperactivity produced by lesions of the ventral noradrenergic bundle in rats

1984 • 2 citations