Activation of mouse microglial cells affects P2 receptor signaling

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

Functional plasticity of microglia: A review

1988 • 931 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1996 • 882 citations

Signalling via ATP in the nervous system

1994 • 441 citations

An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4).

1990 • 380 citations

Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.

1996 • 348 citations

Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase

1997 • 342 citations

P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure

1995 • 323 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 319 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 305 citations

P2X Receptors: An Emerging Channel Family

1996 • 265 citations

Second messenger cascade specificity and pharmacological selectivity of the human P_2Y1‐purinoceptor

1996 • 248 citations

Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization.

1994 • 235 citations

Pharmacological selectivity of the cloned human P_2U‐purinoceptor: potent activation by diadenosine tetraphosphate

1995 • 233 citations

Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages

1990 • 230 citations

Astrocyte-derived interleukin 3 as a growth factor for microglia cells and peritoneal macrophages.

1986 • 210 citations

Molecular cloning and characterization of rat P2Y₄ nucleotide receptor

1998 • 188 citations

Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain

1993 • 173 citations

Electrophysiological behavior of microglia

1993 • 167 citations

ATP-induced cytoplasmic calcium mobilization in Bergmann glial cells

1995 • 166 citations

Pharmacological characterization of the human P2Y4 receptor

1996 • 166 citations

Metabotropic receptors for ATP and UTP: exploring the correspondence between native and recombinant nucleotide receptors

1998 • 157 citations

Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels

1995 • 156 citations

Activation of P2‐purinoreceptors triggered Ca2+ release from InsP3‐sensitive internal stores in mammalian oligodendrocytes.

1995 • 153 citations

Morphological transformation of microglia in vitro

1991 • 151 citations

Numbering of cloned P2 purinoceptors

1996 • 148 citations

Cloning and functional characterisation of the mouse P2X₇ receptor

1998 • 146 citations

Mechanisms of C5a and C3a Complement Fragment-Induced [Ca²⁺]_iSignaling in Mouse Microglia

1997 • 140 citations

Type 3 inositol 1,4,5-trisphosphate receptor and capacitative calcium entry

1997 • 139 citations

Effect of bacterial wall lipopolysaccharide (LPS) on morphology, motility, and cytoskeletal organization of microglia in cultures

1995 • 120 citations

Voltage‐dependent potassium channels in activated rat microglia.

1994 • 110 citations

Synergistic Activation of DNA Synthesis in Astrocytes by Fibroblast Growth Factors and Extracellular ATP

1994 • 107 citations

Inflammatory stimuli induce a new K+ outward current in cultured rat microglia

1992 • 107 citations

Characterisation of the ATP4− receptor that mediates permeabilisation or rat mast cells

1988 • 101 citations

Characterization and possible function of adenosine 5′‐triphosphate receptors in activated rat microglia

1994 • 99 citations

ATP-induced membrane currents in ameboid microglia acutely isolated from mouse brain slices

1996 • 97 citations

Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells

1998 • 93 citations

Phagocytozing ameboid microglial cells studied in a mouse corpus callosum slice preparation

1996 • 92 citations

Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes

1994 • 87 citations

Calcitonin gene‐related peptide and ATP induce immediate early gene expression in cultured rat microglial cells

1995 • 79 citations

Membrane properties of ameboid microglial cells in the corpus callosum slice from early postnatal mice

1993 • 74 citations

P2 purinergic receptors for diadenosine polyphosphates in the nervous system

1995 • 72 citations

Selectivity and activity of adenine dinucleotides at recombinant P2x₂ and P2Y₁ purinoceptors

1996 • 67 citations

Coexistence of purino‐ and pyrimidinoceptors on activated rat microglial cells

1997 • 63 citations

Effects of analogues of adenine nucleotides on increases in intracellular calcium mediated by P_2T‐purinoceptors on human blood platelets

1993 • 61 citations

Carbachol increases intracellular free calcium in cultured rat microglia

1993 • 58 citations

Schwann cell ATP‐mediated calcium increases in vitro and in situ are dependent on contact with neurons

1995 • 53 citations

Receptor-mediated calcium signals in astroglia: multiple receptors, common stores and all-or-nothing responses

1995 • 48 citations

The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules

1996 • 47 citations

Molecular Cloning and Expression of an Avian G Protein-Coupled P2Y Receptor

1997 • 46 citations

RELEASE OF ADENOSINE AND ATP FROM NERVOUS TISSUE

1991 • 39 citations

Distinct soluble astrocytic factors induce expression of outward K+ currents and ramification of brain macrophages

1997 • 26 citations

Effects of adenosine 5’-triphosphate, uridine 5’-triphosphate, adenosine 5’-tetraphosphate and diadenosine polyphosphates in guinea-pig taenia caeci and rat colon muscularis mucosae

1998 • 14 citations

P _2U nucleotide receptor activation in rat glial cell line induces [Ca ²⁺ ] _i oscillations which depend on cytosolic pH

1996 • 13 citations

P2U nucleotide receptor activation in rat glial cell line induces [Ca2+]i oscillations which depend on cytosolic pH

1996 • 11 citations