Penicillin binding protein 2 is dispensable in Escherichia coli when ppGpp synthesis is induced.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

The physical map of the whole E. coli chromosome: Application of a new strategy for rapid analysis and sorting of a large genomic library

1987 • 1,768 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12.

1975 • 962 citations

Linkage map of Escherichia coli K-12, edition 8

1990 • 764 citations

A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli

1989 • 757 citations

Residual guanosine 3‘,5‘-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.

1991 • 722 citations

PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICS

1983 • 698 citations

High-copy-number and low-copy-number plasmid vectors for lacZα-complementation and chloramphenicol- or kanamycin-resistance selection

1987 • 695 citations

Penicillin-binding proteins and cell shape in E. coli

1975 • 369 citations

Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5''-aminoglycoside phosphotransferase type III

1983 • 369 citations

Versatile low-copy-number plasmid vectors for cloning in Escherichia coli

1982 • 361 citations

Mutant isolation and molecular cloning of mre genes, which determine cell shape, sensitivity to mecillinam, and amount of penicillin-binding proteins in Escherichia coli

1987 • 236 citations

Overexpression of the relA gene in Escherichia coli

1991 • 229 citations

6β-Amidinopenicillanic Acids—a New Group of Antibiotics

1972 • 204 citations

Novel regulatory mutants of the phosphate regulon in Escherichia coli K-12

1986 • 179 citations

Phenotypic Tolerance: The Search for β-Lactam Antibiotics That Kill Nongrowing Bacteria

1986 • 170 citations

Cell division and peptidoglycan assembly in Eschenchia coli

1991 • 166 citations

Basal ppGpp level adjustment shown by new spoT mutants affect steady state growth rates and rrnA ribosomal promoter regulation in Escherichia coli

1988 • 165 citations

Abundance and membrane association of elongation factor Tu in E. coli

1976 • 165 citations

The mechanism of action of mecillinam

1977 • 154 citations

Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein.

1986 • 153 citations

Escherichia coli ppGpp synthetase II activity requires spoT.

1991 • 135 citations

Primary Structure of a Large Aminoacyl-tRNA Synthetase

1981 • 130 citations

A procedure for rapid extraction and high-pressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells

1982 • 123 citations

FL-1060: A new penicillin with a unique mode of action

1973 • 118 citations

Cluster of mrdA and mrdB genes responsible for the rod shape and mecillinam sensitivity of Escherichia coli

1980 • 117 citations

Guanosine 3'-diphosphate 5'-diphosphate is not required for growth rate-dependent control of rRNA synthesis in Escherichia coli.

1990 • 113 citations

Mechanism of Action and Development of Resistance to a New Amidino Penicillin

1974 • 111 citations

Isolation and Partial Characterization of Temperature-Sensitive Escherichia coli Mutants with Altered Leucyl- and Seryl-Transfer Ribonucleic Acid Synthetases

1971 • 86 citations

Bacterial cell shape regulation: testing of additional predictions unique to the two-competing-sites model for peptidoglycan assembly and isolation of conditional rod-shaped mutants from some wild-type cocci

1990 • 85 citations

Biophysics of bacterial walls viewed as stress-bearing fabric

1988 • 84 citations

Defective and plaque-forming lambda transducing bacteriophage carrying penicillin-binding protein-cell shape genes: genetic and physical mapping and identification of gene products from the lip-dacA-rodA-pbpA-leuS region of the Escherichia coli chromosome

1980 • 83 citations

Elongation factor Tu is methylated in response to nutrient deprivation in Escherichia coli

1991 • 79 citations

Alteration of Escherichia coli murein during amino acid starvation

1980 • 76 citations

Penicillin-binding protein 2 is essential in wild-type Escherichia coli but not in lov or cya mutants

1989 • 73 citations

Stringent control of peptidoglycan biosynthesis in Escherichia coli K-12

1976 • 70 citations

Suppression of growth and protein secretion defects in Escherichia coli secA mutants by decreasing protein synthesis

1986 • 69 citations

Inhibition of an early event in the cell division cycle of Escherichia coli by FL1060, an amidinopenicillanic acid

1975 • 68 citations

Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site

1984 • 62 citations

Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants

1983 • 62 citations

Quantitation of guanosine 5′,3′-bisdiphosphate in extracts from bacterial cells by ion-pair reverse-phase high-performance liquid chromatography

1982 • 50 citations

Mapping of the mecillinam-resistant, round morphological mutants of Escherichia coli

1978 • 50 citations

Genetic and physiological analysis of an envB spherelike mutant of Escherichia coli K-12 and characterization of its transductants

1975 • 49 citations

Isolation and characterization of the gene coding for Escherichia coli arginyl-tRNA synthetase

1989 • 46 citations

High and selective resistance to mecillinam in adenylate cyclase-deficient or cyclic adenosine 3',5'-monophosphate receptor protein-deficient mutants of Escherichia coli

1979 • 42 citations

Cyclic AMP and cell division in Escherichia coli

1988 • 41 citations

Comparison of the Binding Properties of Two 6β-Amidinopenicillanic Acid Derivatives That Differ in Their Physiological Effects on Escherichia coli

1977 • 41 citations

Mechanism of phenotypic tolerance of nongrowing pneumococci to beta-lactam antibiotics.

1990 • 38 citations

Inhibition of Escherichia coli Division by Protein X

1978 • 36 citations

The Escherichia coli lov gene product connects peptidoglycan synthesis, ribosomes and growth rate.

1989 • 35 citations

Sucrose-dependent spectinomycin-resistant mutants of Escherichia coli

1976 • 29 citations

Gene expression in Escherichia coli B/r during partial rifampicin-mediated restrictions of transcription initiation

1978 • 28 citations

Hyper‐regulation of pyr gene expression in Escherichia coli cells with slow ribosomes

1988 • 26 citations

Appearance of Elongation Factor Tu in the Outer Mernbrane of Sucrose‐Dependent Spectinomycin‐Resistant Mutants ofEscherichia coli

1981 • 24 citations

Coordinated alterations in ribosomes and cytoplasmic membrane in sucrose-dependent, spectinomycin-resistant mutants of Escherichia coli

1976 • 22 citations

Map location of arginyl-tRNA synthetase mutations in Escherichia coli K-12

1969 • 22 citations

Suppression of mutations conferring penicillin tolerance by interference with the stringent control mechanism of Escherichia coli

1987 • 21 citations

Mecillinam Resistance in Escherichia coli: Dissociation of Growth Inhibition and Morphologic Change

1981 • 15 citations

Properties of cell wall peptidoglycan synthesized by amino acid deprived relA mutants of Escherichia coli

1984 • 15 citations

Alanyl-tRNA synthetase of Escherichia coli: Genetic analysis of the structural gene and of suppressor mutations

1974 • 13 citations

Preliminary Physiologic Characterization and Genetic Analysis of a New Escherichia coli Mutant, lov, Resistant to Mecillinam

1988 • 12 citations

Buoyant density studies of several mecillinam-resistant and division mutants of Escherichia coli

1991 • 8 citations