The hepatocyte growth factor and its receptor

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

1991 • 698 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

1989 • 664 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure.

1988 • 657 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures.

1986 • 588 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

Tyrosine kinase receptor indistinguishable from the c-met protein

1989 • 496 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

1989 • 455 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

1988 • 390 citations

Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells

1988 • 368 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.

1992 • 297 citations

The receptor encoded by the human C‐MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors

1991 • 291 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Cytology and Cellular Pathology of the Nervous System.

1932 • 265 citations

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

1991 • 259 citations

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1989 • 256 citations

Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE

1991 • 253 citations

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

1992 • 222 citations

Biosynthesis of the protein encoded by the c-met proto-oncogene.

1989 • 220 citations

Expression of Hepatocyte Growth Factor mRNA in regenerating rat liver after partial hepatectomy

1991 • 219 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation.

1991 • 187 citations

Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

1993 • 159 citations

Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.

1991 • 150 citations

Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes.

1990 • 133 citations

p145, a Protein with Associated Tyrosine Kinase Activity in a Human Gastric Carcinoma Cell Line

1988 • 81 citations

Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains.

1992 • 71 citations

Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.

1990 • 70 citations

Selective expression of the Met/HGF receptor in human central nervous system microglia.

1993 • 67 citations

Intracellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene

1991 • 60 citations

p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line.

1988 • 49 citations

Regional localization of the hepatocyte growth factor (HGF) gene to human chromosome 7 band q21.1

1991 • 42 citations

Regional mapping of the human hepatocyte growth factor (HGF)-scatter factor gene to chromosome 7q21.1

1992 • 27 citations