Tryptophan tolerance and metabolism in endogenous depression

Nonparametric Statistics for the Behavioral Sciences

1958 • 36,277 citations

Development of a Rating Scale for Primary Depressive Illness

1967 • 8,216 citations

Nonparametric statistics for the behavioral sciences

1957 • 6,138 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

The Biochemistry of Affective Disorders

1967 • 1,183 citations

Documenta Geigy; scientific tables.

1963 • 804 citations

The Specific Binding of l-Tryptophan to Serum Albumin

1958 • 638 citations

QUANTITATIVE RATING OF DEPRESSIVE STATES

1975 • 474 citations

NEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION

1978 • 426 citations

Free tryptophan in serum controls brain tryptophan level and serotonin synthesis

1973 • 266 citations

EFFECT OF ALBUMIN BINDING AND AMINO ACID COMPETITION ON TRYPTOPHAN UPTAKE INTO BRAIN

1977 • 200 citations

Effect of the oral administration of tryptophan‐free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism

1974 • 195 citations

SYNTHESIS AND METABOLISM OF <scp>l</scp>‐KYNURENINE IN RAT BRAIN

1978 • 173 citations

Correlation between brain tryptophan and plasma neutral amino acid levels following food consumption in rats

1973 • 170 citations

TOTAL AND FREE TRYPTOPHAN CONCENTRATION IN THE PLASMA OF DEPRESSIVE PATIENTS

1973 • 163 citations

Two mechanisms which increase in vivo the liver tryptophan peroxidase activity: specific enzyme adaptation and stimulation of the pituitary adrenal system.

1951 • 145 citations

Tryptophan Metabolism in Man *

1964 • 134 citations

Tryptophan Pyrrolase—A Biochemical Factor in Depressive Illness?

1969 • 132 citations

A STUDY OF PROPOSED DETERMINANTS OF BRAIN TRYPTOPHAN CONCENTRATION IN RATS AFTER PORTOCAVAL ANASTOMOSIS OR SHAM OPERATION

1978 • 116 citations

The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism

1970 • 88 citations

The brain serotonergic system in the affective disorders

1978 • 86 citations

Brain tryptophan, plasma free tryptophan and distribution of plasma neutral amino acids

1976 • 80 citations

Relationship between plasma ratio of tryptophan to competing amino acids and the response to L-tryptophan treatment in endogenously depressed patients

1980 • 76 citations

TRANSPORT OF <scp>l</scp>‐TRYPTOPHAN INTO SLICES OF RAT CEREBRAL CORTEX¹

1972 • 73 citations

Regulation of Liver Tryptophan Pyrrolase Activity

1962 • 71 citations

Tryptophan metabolism in depression

1970 • 70 citations

Cerebral tryptophan‐2,3‐dioxygenase (pyrrolase) and its induction in rat brain

1974 • 69 citations

Plasma amino acids as an index for subgroups in manic depressive psychosis: Correlation to effect of tryptophan

1976 • 66 citations

Tryptophan‐nicotinamide, imipramine and their combination in depression

1979 • 65 citations

Adrenal Cortical Activity Changes in Manic-Depressive Illness

1967 • 61 citations

Kynurenines as Probable Participants of Depression

1973 • 60 citations

TRYPTOPHAN LOADING: CONSEQUENT EFFECTS ON THE SYNTHESIS OF KYNURENINE AND 5‐HYDROXYINDOLES IN RAT BRAIN

1978 • 57 citations

Tryptophan Metabolism in Affective Psychoses

1966 • 53 citations

LIVER AND BRAIN TRYPTOPHAN METABOLISM FOLLOWING HYDROCORTISONE ADMINISTRATION TO RATS AND GERBILS

1975 • 51 citations

The metabolism of a tryptophan load in rat brain and liver. The influence of hydrocortisone and allopurinol

1976 • 51 citations

Brain serotonin synthesis: reduction in corn‐malnourished rats¹

1977 • 50 citations

Metabolism of Tryptophan in Depressive Disease

1973 • 50 citations

Tyrosine metabolism in manic depressive illness

1968 • 48 citations

Manic-depressive psychosis or manic-melancholic mode.

1974 • 47 citations

Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects

1981 • 46 citations

L‐Tryptophan and 5‐hydroxytryptophan in the treatment of depression

1978 • 43 citations

Importance of tryptophan pyrrolase and aromatic amino acid decarboxylase in the catabolism of tryptophan

1978 • 40 citations

Tryptophan metabolism in depressive illness

1974 • 33 citations

Free and total plasma tryptophan in endogenous depression

1979 • 32 citations

Plasma Tryptophan Concentration in Depressive Illness and Mania

1976 • 31 citations

The effect of antidepressant drugs on plasma kynurenine in depressed patients

1978 • 28 citations

Total and Free Plasma Tryptophan Levels in Patients With Affective Disorders

1976 • 25 citations

Quantitative determination of branched-chain and aromatic amino acids by ion-exchange chromatography

1977 • 25 citations

Plasma tryptophan tolerance curves in drug free normal controls, schizophrenic patients and prisoner volunteers

1974 • 22 citations

Theoretical and Therapeutic Potential of Indoleamine Precursors in Affective Disorders

1977 • 20 citations

Experimental studies on kynurenines as neuroactive tryptophan metabolites: past, present and future

1980 • 19 citations

Evaluation of the relative potency of individual competing amino acids to tryptophan transport in endogenously depressed patients

1980 • 16 citations

Rat liver tryptophan pyrrolase activity and brain 5-hydroxytryptamine

1969 • 14 citations

Serotonin and affective disorders.

1979 • 9 citations

A method for the separation of plasma amino acids by ion-exchange chromatography combined with a semi-automatic computation of plasma amino acid concentrations

1975 • 8 citations

Decreased tryptophan availability in endogenous depression caused by disturbed plasma leucine clearance

1981 • 7 citations

The effect of clofibrate on total and free plasma tryptophan in depressed patients

1978 • 6 citations

Plasma tryptophan transport in normal and depressed subjects.

1975 • 5 citations

The uptake of kynurenine, a tryptophan metabolite, into mouse brain [proceedings].

1979 • 3 citations