Aortic atherosclerosis in diabetes mellitus is associated with an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

1990 • 3,809 citations

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

1992 • 1,956 citations

PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)

1992 • 1,280 citations

Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury

1989 • 1,061 citations

A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

1995 • 920 citations

Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.

1991 • 751 citations

Mistyping ACE heterozygotes.

1993 • 522 citations

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

1993 • 470 citations

Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.

1990 • 419 citations

Angiotensin-converting enzyme: new concepts concerning its biological role

1989 • 400 citations

Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications

1994 • 361 citations

Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese.

1994 • 276 citations

Deletion polymorphism in angiotensin-converting enzyme gene associated with parental history of myocardial infarction

1993 • 262 citations

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.

1994 • 236 citations

Increased aortic stiffness in patients with Type 1 (insulin-dependent) diabetes mellitus

1989 • 135 citations

Insertion/deletion (I/D) polymorphism at the locus for angiotensin I‐converting enzyme and myocardial infarction

1993 • 111 citations

ε-Amino-Lysine-Bound Glucose in Human Tissues Obtained at Autopsy: Increase in Diabetes Mellitus

1982 • 111 citations

Angiotensin I-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction, but Not With Retinopathy or Nephropathy, in NIDDM

1995 • 100 citations

Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart

1993 • 92 citations

Insertion/deletion polymorphism in the angiotensin-l-converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathy

1995 • 86 citations

Angiotensin II regulates tenascin gene expression in vascular smooth muscle cells.

1992 • 78 citations

Glycosaminoglycans in the human aorta in diabetes mellitus: a study of tunica media from areas with and without atherosclerotic plaque

1994 • 74 citations

A quantitative study of peripheral arterial calcification and glucose tolerance in elderly diabetics and non-diabetics

1971 • 64 citations

ACE inhibition with perindopril and atherogenesis-induced structural and functional changes in minipig arteries.

1993 • 57 citations

Aortic collagen alterations in human diabetes mellitus. Changes in basement membrane collagen content and in the susceptibility of total collagen to cyanogen bromide solubilisation

1993 • 47 citations

UK Prospective Diabetes Study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM

1995 • 42 citations

Accumulation of fibronectin in aortas from diabetic patients. A quantitative immunohistochemical and biochemical study.

1989 • 39 citations

Diabetic macroangiopathy. Quantitative histopathological studies of the extramural coronary arteries from type 2 (non-insulin-dependent) diabetic patients.

1987 • 36 citations

Diabetic macroangiopathy

1987 • 27 citations

Editor's note

1993 • 19 citations