A semiparametric approach to physiological flow models

A Note on the Generation of Random Normal Deviates

1958 • 3,337 citations

Theory of Functionals and of Integral and Integro-Differential Equations

2005 • 1,303 citations

Computational Methods for Integral Equations

1985 • 1,198 citations

Clearance concepts in pharmacokinetics

1973 • 741 citations

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

1982 • 629 citations

Animal scale-up

1973 • 389 citations

THEOREMS ON LINEAR SYSTEMS*

1963 • 271 citations

Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion model

1974 • 214 citations

Numerical parameter identifiability and estimability: Integrating identifiability, estimability, and optimal sampling design

1985 • 191 citations

Measurement of the distribution of cardiac output in unanesthetized rats

1971 • 148 citations

Transport and Binding of Methotrexate In Vivo

1973 • 147 citations

Mathematical Basis of Point–Area Deconvolution Method for Determining In Vivo Input Functions

1978 • 125 citations

Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models

1979 • 119 citations

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

1988 • 109 citations

Numerical deconvolution by least squares: Use of prescribed input functions

1978 • 105 citations

Identifiability of compartmental systems and related structural properties

1979 • 94 citations

Area method for the estimation of partition coefficients for physiological pharmacokinetic models

1987 • 86 citations

Some mathematical aspects of chemotherapy: I. One-organ models

1960 • 75 citations

Some fundamental considerations of the applications of pharmacokinetics to cancer chemotherapy.

1975 • 71 citations

Pharmacology and Pharmacokinetics

1974 • 70 citations

An inequality-constrained least-squares deconvolution method

1989 • 56 citations

Theory of transport in linear biological systems: I. Fundamental integral equation

1960 • 55 citations

Some mathematical aspects of chemotherapy—II: The distribution of a drug in the body

1960 • 55 citations

The use of mass balance principles to describe regional drug distribution and elimination

1988 • 49 citations

Theorems and implications of a model independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. I. Derivations and theoretical analysis

1984 • 48 citations

Controlled release of tetracycline—III: A physiological pharmacokinetic model of the pregnant rat

1980 • 44 citations

A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat

1984 • 43 citations

Maximum entropy and its application to the calculation of drug absorption rates

1987 • 41 citations

Concepts, properties, measurement, and computation of clearance rates of hormones and other substances in biological systems

1976 • 40 citations

High-performance liquid chromatographic method for determining thiopental concentrations in twelve rat tissues: Application to physiologic modeling of disposition of barbiturate

1989 • 34 citations

Comments on mean residence time determination

1985 • 22 citations

Theory of transport in linear biological systems: II. Multiflux problems

1960 • 19 citations

Development and identification of a multicompartment model for the distribution of adriamycin in the rat

1981 • 14 citations

Drug Kinetics in Low-Flux (Small) Anatomic Compartments

1983 • 13 citations

A Novel Pharmacokinetic Method for Analysis of Placental Transfer of Latamoxef in Humans

1986 • 7 citations