Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

Chemical Reaction Engineering

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Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum

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Fundamentals of Clinical Pharmacokinetics

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Fundamentals of clinical pharmacokinetics

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Clearance concepts in pharmacokinetics

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Boundary conditions of flow reactor

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Diffusion Processes and Related Topics in Biology

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Chemical reaction engineering

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On the Uptake of Materials by the Intact Liver. THE TRANSPORT AND NET REMOVAL OF GALACTOSE

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A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations

1986 • 256 citations

Boundary conditions of flow reactor

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Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

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Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

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Functional implications of liver cell heterogeneity

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Vasomotor control of capillary transit time heterogeneity in the canine coronary circulation.

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Hepatic elimination of flowing substrates: The distributed model

1978 • 119 citations

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1947 • 99 citations

Hepatic Eliminatilon—Dispersion Model

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A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

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Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver.

1978 • 87 citations

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Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

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THE TERMINAL HEPATIC MICROCIRCULATION IN THE RAT

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Tracer dilution curves in cardiology and random walk and lognormal distributions.

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A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics

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Moments of physiological transit time distributions and the time course of drug disposition in the body

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Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding.

1984 • 52 citations

A generalization of the tanks‐in‐series mixing model

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Use of gamma distributed residence times in pharmacokinetics

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The Hepatic Sinusoid is Not Well-Stirred: Estimation of the Degree of Axial Mixing by Analysis of Lobular Concentration Gradients Formed During Uptake of Thyroxine by the Perfused Rat Liver

1986 • 47 citations

Kinetic interpretation of hepatic multiple-indicator dilution studies

1983 • 46 citations

On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

1987 • 37 citations

Flow dependence of first-order uptake of substances by heterogeneous perfused organs

1980 • 37 citations

Flow dependence of propranolol elimination in perfused rat liver.

1984 • 34 citations

An understanding of the role of enzyme localization of the liver on metabolite kinetics: A computer simulation

1983 • 28 citations

Hepatic drug clearance model: Comparison among the distributed, parallel-tube and well-stirred models.

1985 • 23 citations

Albumin Binding and Hepatic Uptake: The Importance of Model Selection

1983 • 22 citations

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

1983 • 18 citations

Erythrocytes as a Slow Release Carrier System for Propranolol and its Prodrugs

1986 • 8 citations

Convection-Dispersion Modeling of Hepatic Elimination

1986 • 6 citations

Hepatic transport kinetics: effect of anatomic and metabolic heterogeneity on estimates of the average transfer coefficients

1982 • 6 citations