A systematic comparison of kinetic modelling methods generating parametric maps for [11C]-(R)-PK11195

Intraclass correlations: Uses in assessing rater reliability.

1979 • 21,275 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

1996 • 1,461 citations

Three‐dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe

2003 • 1,156 citations

Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model

1997 • 1,064 citations

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

2005 • 1,062 citations

In-vivo measurement of activated microglia in dementia

2001 • 1,025 citations

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study

2004 • 690 citations

Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain

2001 • 495 citations

Positron Emission Tomography Compartmental Models

2001 • 474 citations

Microglial activation correlates with severity in Huntington disease

2006 • 425 citations

Visualising microglial activation in vivo

2002 • 422 citations

Microglial phenotype: is the commitment reversible?

2006 • 421 citations

Reference and target region modeling of [11C]-(R)-PK11195 brain studies.

2007 • 263 citations

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

2004 • 250 citations

[ ¹¹ C]( R )-PK11195 PET imaging of microglial activation in multiple system atrophy

2003 • 235 citations

Validation and Reproducibility of Measurement of 5-HT_1A Receptor Parameters with [carbonyl-¹¹C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions

2000 • 229 citations

Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination

2004 • 222 citations

Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling

2002 • 216 citations

PET visualization of microglia in multiple sclerosis patients using [¹¹C]PK11195

2003 • 213 citations

The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development

2005 • 194 citations

Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats

1994 • 185 citations

In vivo imaging of microglial activation with [¹¹C](R)‐PK11195 PET in progressive supranuclear palsy

2005 • 165 citations

Physical characteristics of the ECAT EXACT3D positron tomograph

2000 • 156 citations

Assessment of Neuroinflammation and Microglial Activation in Alzheimer’s Disease with Radiolabelled PK11195 and Single Photon Emission Computed Tomography

2003 • 147 citations

In vivo imaging of microglial activation with [¹¹C](R)‐PK11195 PET in corticobasal degeneration

2004 • 136 citations

Peripheral-type benzodiazepine receptors in the living heart characterized by positron emission tomography.

1986 • 126 citations

Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease

2006 • 120 citations

Imaging glial cell activation with [¹¹C]-R-PK11195 in patients with AIDS

2005 • 109 citations

Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis

1995 • 106 citations

Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

2005 • 96 citations

Evaluation of Reference Tissue Models for the Analysis of [¹¹C](R)-PK11195 Studies

2006 • 92 citations

Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods.

2006 • 83 citations

Development of a Tracer Kinetic Plasma Input Model for (R)-[¹¹C]PK11195 Brain Studies

2005 • 80 citations

Inhibition of lipopolysaccharide‐induced cyclooxygenase‐2, tumor necrosis factor‐α and [Ca²⁺]_i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195

2002 • 80 citations

Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling

2002 • 79 citations

A comparison of recent parametric neuroreceptor mapping approaches based on measurements with the high affinity PET radioligands [11C]FLB 457 and [11C]WAY 100635

2006 • 73 citations

A linear wavelet filter for parametric imaging with dynamic pet

2003 • 69 citations

The effect of activity outside the direct field of view in a 3D-only whole-body positron tomograph

1998 • 58 citations

Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET

2005 • 50 citations

Semiquantification of the peripheral-type benzodiazepine ligand [11C]PK11195 in normal human brain and application in multiple sclerosis patients.

2002 • 42 citations

Optimization of dynamic measurement of receptor kinetics by wavelet denoising

2005 • 36 citations

Microarrays and expression profiling in microglia research and in inflammatory brain disorders

2005 • 31 citations

Wavelet variance components in image space for spatiotemporal neuroimaging data

2005 • 18 citations

Bootstrapped DEPICT for error estimation in PET functional imaging

2004 • 15 citations

Quantitative in vivo imaging of microglia activation using [11C]PK11195 and two reference tissue models

2006 • 3 citations