Isolation and characterization of Chinese hamster ovary cell mutants deficient in acyl-coenzyme A:cholesterol acyltransferase activity.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis

1983 • 1,681 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation

1971 • 1,364 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

PREPARATION OF LIPIDE EXTRACTS FROM BRAIN TISSUE

1951 • 1,307 citations

Chromatographically homogeneous lecithin from egg phospholipids

1965 • 1,304 citations

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

1980 • 903 citations

CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM

1965 • 833 citations

Production of mammalian somatic cell hybrids by means of polyethylene glycol treatment

1975 • 549 citations

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

1985 • 519 citations

A solvent system for delipidation of plasma or serum without protein precipitation

1976 • 515 citations

The picomole determination of free and total cholesterol in cells in culture.

1978 • 440 citations

The Specificity of Triglyceride Synthesis from Diglycerides in Chicken Adipose Tissue

1961 • 402 citations

Ouabain-resistant mutants of mouse and hamster cells in culture

1974 • 393 citations

Fatty acid synthesis in adipose tissue incubated in tritiated water

1968 • 390 citations

Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro.

1968 • 376 citations

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

1975 • 364 citations

[137] Preparation and assay of acyl coenzyme A and other thiol esters; use of hydroxylamine

1957 • 354 citations

Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. I. Specificity of the membrane permeability changes induced by the polyene antibiotics

1974 • 330 citations

The Formation of Cholesterol Esters with Rat Liver Enzymes

1964 • 304 citations

Polyethylene glycol-induced mammalian cell hybridization: Effect of polyethylene glycol molecular weight and concentration

1976 • 300 citations

Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids

1967 • 298 citations

Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia

1974 • 287 citations

8-AZAGUANINE RESISTANCE IN MAMMALIAN CELLS I. HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE

1972 • 273 citations

Analysis of the distribution of cholesterol in the intact cell.

1983 • 237 citations

Chapter 7: Isolation of Mutants of Cultured Mammalian Cells

1973 • 232 citations

Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035.

1984 • 230 citations

Processing of Apolipoprotein B-100 of Human Plasma Low Density Lipoproteins by Tissue and Plasma Kallikreins

1986 • 201 citations

A genetic storage disorder in BALB/C mice with a metabolic block in esterification of exogenous cholesterol.

1984 • 188 citations

Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells.

1980 • 172 citations

Type C Niemann-Pick disease. Abnormal metabolism of low density lipoprotein in homozygous and heterozygous fibroblasts.

1986 • 167 citations

Degradation of apolipoprotein B-100 of human plasma low density lipoproteins by tissue and plasma kallikreins.

1984 • 165 citations

The participation of sterol carrier protein2 in the conversion of cholesterol to cholesterol ester by rat liver microsomes.

1981 • 154 citations

Synthesis of fatty acyl CoA and other thiol esters using N-hydroxysuccinimide esters of fatty acids

1969 • 146 citations

Some physical properties of palmityl-coenzyme a micelles

1968 • 141 citations

Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver.

1987 • 135 citations

Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein

1981 • 127 citations

Measurement of rate of rat liver sterol synthesis in vivo using tritiated water.

1977 • 114 citations

Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification

1980 • 99 citations

The submicrosomal localization of acyl-coenzyme A–cholesterol acyltransferase and its substrate, and of cholesteryl esters in rat liver

1978 • 85 citations

Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation.

1986 • 80 citations

Regulation of cholesterol synthesis in primary rat hepatocyte culture cells. Possible regulatory site at sterol demethylation.

1979 • 74 citations

Smooth microsomes. a trap for cholesteryl ester formed in hepatic microsomes.

1980 • 69 citations

Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 1. Effect of exogenous sterols

1986 • 69 citations

Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor.

1979 • 67 citations

Expression of transformation in cell hybrids. I. Isolation and application of density-inhibited Balb/3T3 cells deficient in hypoxanthine phosphoribosyltransferase and resistant to ouabain

1976 • 60 citations

Acyl-CoA:Cholesterol acyltransferase in chinese hamster ovary cells

1982 • 60 citations

Solubilization, partial purification, and reconstitution in phosphatidylcholine-cholesterol liposomes of acyl-CoA:cholesterol acyltransferase

1982 • 60 citations

Mammalian cell mutant requiring cholesterol and unsaturated fatty acid for growth.

1978 • 48 citations

Revertants of a Chinese hamster ovary cell mutant resistant to suppression by an analog of cholesterol: isolation and partial biochemical characterization

1982 • 47 citations

Evidence for coordinate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase ad low density lipoprotein binding activity.

1981 • 45 citations

Increased Cholesterol-Ester Formation during Forced Cholesterol Synthesis in Rat Hepatocytes

1975 • 44 citations

Expression and regulation of human low-density lipoprotein receptors in Chinese hamster ovary cells

1984 • 44 citations

A simple and efficient procedure for the rapid homogenization of cultured animal cells grown in monolayer

1981 • 43 citations

15 Acyl Coenzyme A: Cholesterol O-Acyltransferase

1983 • 39 citations

Cycloheximide sensitivity in regulation of acyl coenzyme A:cholesterol acyltransferase activity in Chinese hamster ovary cells. 2. Effect of sterol endogenously synthesized

1986 • 28 citations

Use of fluorescence-activated cell sorter to isolate mutant mammalian cells deficient in an internal protein, dihydrofolate reductase

1985 • 18 citations

Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine

1986 • 15 citations

Report on the American Society of Biological Chemists satellite conference on Regulation of Intracellular Cholesterol Esterification.

1984 • 10 citations