A History of the Use of Anticonvulsants as Mood Stabilizers in the Last Two Decades of the 20th Century

A PROPOSED MECHANISM OF EMOTION

1937 • 3,511 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Transduction of psychosocial stress into the neurobiology of recurrent affective disorder

1992 • 1,822 citations

Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression

1996 • 1,204 citations

Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression

1995 • 913 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

Antidepressant-induced mania and cycle acceleration: a controversy revisited

1995 • 600 citations

Lithium As a Prophylactic Agent

1967 • 569 citations

Mood Improvement Following Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients With Depression: A Placebo-Controlled Crossover Trial

1997 • 568 citations

EFFECTS OF THYROTROPIN-RELEASING HORMONE IN DEPRESSION*1

1972 • 558 citations

Lithium Carbonate and Imipramine in Prevention of Affective Episodes

1973 • 450 citations

Course of the Manic-Depressive Cycle and Changes Caused by Treatments

2008 • 445 citations

Rapid Cycling in Manic-Depressives Induced by Tricyclic Antidepressants

1979 • 405 citations

IMPROVEMENT IN MENTAL DEPRESSION WITH DECREASED THYROTROPIN RESPONSE AFTER ADMINISTRATION OF THYROTROPIN-RELEASING HORMONE

1972 • 374 citations

Convulsive therapy : theory and practice

1979 • 319 citations

Comparative Prophylactic Efficacy of Lithium, Carbamazepine, and the Combination in Bipolar Disorder

1997 • 313 citations

Prefrontal cortex dysfunction in clinical depression

1994 • 306 citations

Effect of sleep deprivation on brain metabolism of depressed patients

1992 • 291 citations

Regional Cerebral Blood Flow in Mood Disorders, III

1994 • 261 citations

Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat

1980 • 261 citations

Does the Engram of Kindling Model the Engram of Normal Long Term Memory?

1975 • 220 citations

CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls

1984 • 214 citations

Anticonvulsant and antidepressant properties of electroconvulsive therapy: a proposed mechanism of action.

1983 • 208 citations

Effects of sleep deprivation on the limbic system and the frontal lobes in affective disorders: A study with Tc-99m-HMPAO SPECT

1991 • 197 citations

Lamotrigine

1995 • 197 citations

Switch from Depression to Mania – A Record Study over Decades between 1920 and 1982

1985 • 180 citations

Therapeutic effects of carbamazepine in affective illness: a preliminary report.

1978 • 178 citations

Quenching

1995 • 175 citations

The place of anticonvulsant therapy in bipolar illness

1996 • 157 citations

Flupenthixol decanoate in recurrent manic‐depressive illness

1981 • 155 citations

The Induction of Mania

1982 • 153 citations

The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker

1985 • 151 citations

Anti‐Manic and Prophylactic Effects of Carbamazepine (Tegretol) on Manic Depressive Psychosis A Preliminary Report

1973 • 149 citations

Valproate oral loading in the treatment of acute mania.

1993 • 136 citations

Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression

1979 • 136 citations

Elevation of immunoreactive CSF TRH in depressed patients

1988 • 119 citations

Mechanisms of Action of Anticonvulsants in Affective Disorders

1992 • 119 citations

Die Konvulsionstherapie der Schizophrenie

1937 • 118 citations

Effects of Intrathecal Thyrotropin-Releasing Hormone (Protirelin) in Refractory Depressed Patients

1997 • 112 citations

Antiepileptic and Psychotropic Effect of Carbamazepine (Tegretol®) in the Treatment of Psychomotor Epilepsy

1971 • 111 citations

Alterations in mRNA of enkephalin, dynorphin and thyrotropin releasing hormone during amygdala kindling: an in situ hybridization study

1992 • 110 citations

Possible role of antidepressants in precipitating mania and hypomania in recurrent depression

1988 • 108 citations

IMPROVEMENT IN MENTAL DEPRESSION WITH DECREASED THYROTROPIN RESPONSE AFTER ADMINISTRATION OF THYROTROPIN-RELEASING HORMONE

1972 • 106 citations

Quenching Revisited: Low Level Direct Current Inhibits Amygdala-Kindled Seizures

1998 • 99 citations

A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures

1996 • 97 citations

Functional Brain Imaging, Limbic Function, and Affective Disorders

1996 • 97 citations

Valproate in the Treatment of Rapid-Cycling Bipolar Disorder

1988 • 95 citations

Valproate treatment of panic disorder and lactate-induced panic attacks

1993 • 94 citations

Tiagabine

1998 • 92 citations

Valproate in the Treatment of Acute Mania

1996 • 92 citations

Long-term outcome of lithium prophylaxis in patients initially classified as complete responders

1989 • 91 citations

Carbamazepine prophylaxis in refractory affective disorders: a focus on long-term follow-up.

1990 • 91 citations

Acute Treatment of Bipolar Depression with Gabapentin

1997 • 85 citations

Electroconvulsive Seizures Inhibit Amygdala Kindling: Implications for Mechanisms of Action in Affective Illness

1984 • 79 citations

Contingent tolerance to the anticonvulsant effects of carbamazepine: Relationship to loss of endogenous adaptive mechanisms

1995 • 75 citations

Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships

1997 • 72 citations

Endogenous biochemical abnormalities in affective illness: Therapeutic versus pathogenic

1992 • 63 citations

Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: Confounding effects of tolerance and implications for therapeutics

1997 • 63 citations

Valproate prophylaxis in a prospective clinical trial of refractory bipolar disorder

1997 • 60 citations

Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine

1994 • 58 citations

Effects of diazepam and diphenylhydantoin on elicited and spontaneous seizures in kindled rats: A double dissociation

1983 • 53 citations

ATTEMPTS AT TREATMENT OF SCHIZOPHRENIA AND OTHER NONEPILEPTIC PSYCHOSES WITH DILANTIN

1943 • 46 citations

Valproic Acid

1994 • 46 citations

Antiepileptic drugs in affective illness. Clinical and theoretical implications.

1991 • 43 citations

Chronic carbamazepine inhibits the development of local anesthetic seizures kindled by cocaine and lidocaine

1989 • 41 citations

Drug-Induced Switching in Bipolar Disorder

1997 • 40 citations

Tardive Dyskinesia in Bipolar Affective Disorder

1991 • 35 citations

Hepatic ADH and ALDH isoenzymes in different racial groups and in chronic alcoholism

1983 • 35 citations

Caveats in the use of the Kindling Model of Affective Disorders

1994 • 35 citations

Chronic neuroleptic use in manic-depressive illness.

1993 • 34 citations

Treatment of Mood Disorders with Antiepileptic Medications: Clinical and Theoretical Implications

1983 • 33 citations

[Use of valpromide in psychiatric therapeutics].

1987 • 31 citations

Contingent tolerance and reresponse to carbamazepine: a case study in a patient with trigeminal neuralgia and bipolar disorder

1992 • 29 citations

The prolonged increase in thyrotropin-releasing hormone in rat limbic forebrain regions following electroconvulsive shock

1987 • 29 citations

Antipsychotic and Prophylactic Effects of Acetazolamide (Diamox) on Atypical Psychosis

1984 • 29 citations

EFFECTIVENESS OF DIPHENYLHYDANTOIN IN MANAGEMENT OF NONEPILEPTIC PSYCHOMOTOR EXCITEMENT STATES

1945 • 26 citations

Do antidepressants cause mania?

1987 • 26 citations

Alternative approaches to refractory depression in bipolar illness

1997 • 25 citations

The use of dilantin in the treatment of psychotic patients unresponsive to other treatment.

1946 • 24 citations

Use of single case analyses in off‐on‐off‐on trials in affective illness: A demonstration of the efficacy of nimodipine

1994 • 21 citations

Cross-tolerance between carbamazepine and valproate on amygdala-kindled seizures

1993 • 18 citations

Prophylaxis of Bipolar Affective Disorders

1990 • 18 citations

Statistical approaches to trial durations in episodic affective illness

1998 • 17 citations

The cholinergic REM induction test with RS 86 after scopolamine pretreatment in healthy subjects

1991 • 16 citations

Barbiturate Anticonvulsants in Refractory Affective Disorders

1993 • 16 citations

Lamotrigine in treatment refractory manic depression

1996 • 13 citations

Mechanism of Action of Lithium: Comparison and Contrast with Carbamazepine

1991 • 13 citations

A Remarkable Medicine Has Been Overlooked

1981 • 11 citations