Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: Confounding effects of tolerance and implications for therapeutics

A RATING SCALE FOR DEPRESSION

1960 • 30,921 citations

J Neuropsychiatry Clin Neurosci

1992 • 3,756 citations

SALMONELLAS IN MEAT.

1964 • 1,158 citations

Thyrotropin-Releasing Hormone

1982 • 680 citations

EFFECTS OF THYROTROPIN-RELEASING HORMONE IN DEPRESSION*1

1972 • 558 citations

Thyrotropin-Releasing Hormone: Regional Distribution in Rat Brain

1974 • 421 citations

Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study

1993 • 418 citations

IMPROVEMENT IN MENTAL DEPRESSION WITH DECREASED THYROTROPIN RESPONSE AFTER ADMINISTRATION OF THYROTROPIN-RELEASING HORMONE

1972 • 374 citations

Thyrotropin Releasing Hormone: Enhancement of Dopa Activity by a Hypothalamic Hormone

1972 • 283 citations

Graphic representation of the life course of illness in patients with affective disorder

1988 • 192 citations

Regulatory peptides as a source of new drugs — the clinical prospects for analogues of TRH which are resistant to metabolic degradation

1982 • 173 citations

The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker

1985 • 151 citations

Continuous infusion of intrathecal baclofen: long-term effects on spasticity in spinal cord injury

1991 • 144 citations

Affective State and Thyrotropin and Prolactin Responses After Repeated Injections of Thyrotropin-Releasing Hormone in Depressed Patients

1974 • 142 citations

Thyrotrophin releasing hormone: endocrine and central effects

1985 • 137 citations

Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression

1979 • 136 citations

Elevation of immunoreactive CSF TRH in depressed patients

1988 • 119 citations

THYROTROPHIN-RELEASING HORMONE IN THE TREATMENT OF DEPRESSION

1974 • 109 citations

Paraventricular nucleus lesions abolish the inhibition of feeding induced by systemic cholecystokinin

1985 • 104 citations

Metabolism and Excretion of Exogenous Thyrotropin-Releasing Hormone in Humans

1973 • 103 citations

Vagotomy abolishes the inhibitory effects of cholecystokinin on rat exploratory behaviors

1981 • 103 citations

Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone

1985 • 93 citations

Amyotrophic lateral sclerosis

1986 • 83 citations

Thyrotropin-releasing hormone

1983 • 72 citations

Pharmaco-behavioral effects of hypothalamic peptides in animals and man: focus on thyrotropin-releasing hormone and neurotensin

1978 • 68 citations

Endogenous biochemical abnormalities in affective illness: Therapeutic versus pathogenic

1992 • 63 citations

A DOUBLE-BLIND CROSSOVER SEQUENTIAL TRIAL OF ORAL THYROTROPHIN-RELEASING HORMONE IN DEPRESSION

1974 • 60 citations

Intravenous procaine as a probe of limbic system activity in psychiatric patients and normal controls

1987 • 56 citations

Autoradiographic localization of thyr tropin releasing hormone receptors in human brain

1986 • 45 citations

Protirelin (TRH) in Depression

1974 • 44 citations

Treatment of rats with the TRH analog MK-771

1985 • 41 citations

Intrathecal morphine in the treatment of chronic intractable pain

1994 • 40 citations

Thyrotropin-releasing hormone causes direct excitation of dorsal vagal and solitary tract neurones in rat brainstem slices

1990 • 40 citations

Thyrotropin-Releasing Hormone Effects in the Central Nervous System: Dependence on Arousal State

1981 • 39 citations

Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin

1983 • 38 citations

Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability

1981 • 35 citations

Treatment of endogenous depression with oral thyrotropin‐releasing hormone and amitriptyline

1978 • 33 citations

Involvement of adrenergic receptor mechanisms within hypothalamus in the fever induced by amphetamine and thyrotropin-releasing hormone in the rat

1983 • 30 citations

Influence of the route of administration on thyrotropin-releasing hormone concentration in the mouse brain

1983 • 28 citations

Intrathecal thyrotropin-releasing hormone therapy of amyotrophic lateral sclerosis

1985 • 27 citations

Prolonged intrathecal chemotherapy replacing cranial irradiation in high-risk acute lymphatic leukaemia: Long-term follow up with cerebral computed tomography scans and endocrinological studies

1995 • 24 citations

Intrathecal Thyrotropin-Releasing Hormone in Amyotrophic Lateral Sclerosis

1987 • 24 citations

Loin pain hematuria syndrome: Pain relief with intrathecal morphine

1995 • 24 citations

Preliminary studies on the use of thyrotropin releasing hormone in manic states, depression, and the dysphoria of alcohol withdrawal.

1975 • 24 citations

Therapeutic Failure of Oral Thyrotropin-Releasing Hormone in Depression

1976 • 23 citations

Advances in Drug Delivery Systems and Applications in Neurosurgery

1991 • 20 citations

TRH by slow, continuous infusion: an antidepressant?

1976 • 19 citations

Pyroglutamyl peptidase-II ("thyroliberinase") activity in human serum: influence of weight and thyroid status.

1995 • 17 citations

Pharrnacokinetics of intrathecal thyrotropin‐releasing hormone

1987 • 17 citations

Thyrotropin releasing hormone uptake into serum and cerebrospinal fluid following intravenous or subcutaneous administration

1988 • 6 citations

Inhibition of Pyroglutamyl Peptidase II Synthesis by Phorbol Ester in the Y-79 Retinoblastoma Cell*

1991 • 3 citations