Ligand-dependent Antagonism by Retinoid X Receptors of Inhibitory Thyroid Hormone Response Elements

Gene regulation by steroid hormones

1989 • 3,466 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box.

1989 • 222 citations

Identification of Nuclear Factors that Enhance Binding of the Thyroid Hormone Receptor to a Thyroid Hormone Response Element

1989 • 219 citations

Thyroid Hormone Regulates the Mouse Thyrotropin β-Subunit Gene Promoter in Transfected Primary Thyrotropes

1989 • 203 citations

A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements.

1990 • 192 citations

Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.

1992 • 190 citations

Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance

1993 • 149 citations

Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element.

1991 • 134 citations

3,5,3′-Triiodothyronine (T₃) Receptor-Auxiliary Protein (TRAP) Binds DNA and Forms Heterodimers with the T₃Receptor

1991 • 130 citations

Thyroid Hormone Inhibition of Human Thyrotropin β-Subunit Gene Expression is Mediated by a Cis-acting Element Located in the First Exon

1989 • 119 citations

A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.

1991 • 104 citations

Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors.

1992 • 95 citations

The rat growth hormone gene contains multiple thyroid response elements

1989 • 92 citations

Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.

1992 • 88 citations

Thyroid Hormone Receptors Form Distinct Nuclear Protein-Dependent and Independent Complexes with a Thyroid Hormone Response Element

1990 • 82 citations

Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways.

1993 • 79 citations

Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements.

1992 • 79 citations

Characteristics of a negative thyroid hormone response element.

1994 • 71 citations

Mutational Analysis Identifies a New Functional Domain of the Thyroid Hormone Receptor

1990 • 70 citations

Divergent effects of 9-cis-retinoic acid receptor on positive and negative thyroid hormone receptor-dependent gene expression.

1993 • 61 citations

Thyroid hormone inhibits thyrotropin gene expression via a position-independent negative L-triiodothyronine-responsive element.

1992 • 59 citations

AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.

1993 • 54 citations

Ligand-dependent synergy of thyroid hormone and retinoid X receptors.

1992 • 53 citations

Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content.

1995 • 43 citations