Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

Evidence for Possible Involvement of 5-HT _2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

2000 • 668 citations

Appetite-suppressant drugs and the risk of primary pulmonary hypertension

1997 • 582 citations

Increased plasma serotonin in primary pulmonary hypertension

1995 • 551 citations

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

2001 • 506 citations

Altered Growth Responses of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension to Transforming Growth Factor-β ₁ and Bone Morphogenetic Proteins

2001 • 453 citations

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

2001 • 450 citations

Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.

1999 • 427 citations

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine.

2000 • 403 citations

Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor

2000 • 373 citations

Serotonin 2B receptor is required for heart development

2000 • 357 citations

Expression of serotonin receptor mRNAs in blood vessels

1995 • 331 citations

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene

2000 • 318 citations

A new role for an old molecule: serotonin as a mitogen

1997 • 253 citations

Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.

1998 • 232 citations

5‐hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

2000 • 229 citations

Contribution of the 5-HT _1B Receptor to Hypoxia-Induced Pulmonary Hypertension

2001 • 217 citations

Anorexigens and Pulmonary Hypertension in the United States

2000 • 190 citations

5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways

2000 • 177 citations

Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion

1999 • 139 citations

High Plasma Serotonin Levels in Primary Pulmonary Hypertension

2000 • 137 citations

Ablation of Serotonin 5-HT _2B Receptors in Mice Leads to Abnormal Cardiac Structure and Function

2001 • 136 citations

Prostacyclin Receptor-dependent Modulation of Pulmonary Vascular Remodeling

2001 • 133 citations

Ras Involvement in Signal Transduction by the Serotonin 5-HT2B Receptor

1996 • 132 citations

Regression of Hypertrophied Rat Pulmonary Arteries in Organ Culture Is Associated With Suppression of Proteolytic Activity, Inhibition of Tenascin-C, and Smooth Muscle Cell Apoptosis

1999 • 125 citations

Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension

1999 • 115 citations

RS‐127445: a selective, high affinity, orally bioavailable 5‐HT_2B receptor antagonist

1999 • 114 citations

Further evidence that 5‐HT‐induced relaxation of pig pulmonary artery is mediated by endothelial 5‐HT_2B receptors

2000 • 89 citations

NPR-A–Deficient Mice Show Increased Susceptibility to Hypoxia-Induced Pulmonary Hypertension

1999 • 83 citations

Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture

1994 • 76 citations

5‐HT_2B receptor‐mediated calcium release from ryanodine‐sensitive intracellular stores in human pulmonary artery endothelial cells

1996 • 71 citations

Hypoxia increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries.

1997 • 68 citations

Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?

1999 • 67 citations

EFFECT OF FENFLURAMINE ON 5‐HYDROXYTRYPTAMINE UPTAKE AND RELEASE BY RAT BLOOD PLATELETS

1975 • 65 citations

Pulmonary arterial hypertension and type-I glycogen-storage disease: the serotonin hypothesis

2002 • 62 citations

EVE and beyond, retro and prospective insights

1999 • 58 citations

Anorectic Drugs and Pulmonary Hypertension from the Bedside to the Bench

2001 • 53 citations

Role of Vascular Smooth Muscle in the Development of High Altitude Pulmonary Hypertension: An Interspecies Evaluation

2001 • 46 citations

Miscellaneous Item

1997 • 44 citations

Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats.

2001 • 43 citations

Effect of Dexfenfluramine Treatment in Rats Exposed to Acute and Chronic Hypoxia

1998 • 41 citations

Linking a serotonin transporter polymorphism to vascular smoothmuscle proliferation in patients with primary pulmonary hypertension

2001 • 35 citations

Linking a serotonin transporter polymorphism to vascular smoothmuscle proliferation in patients with primary pulmonary hypertension

2001 • 27 citations

Cellular and molecular mechanisms responsible for the pathogenesis of primary pulmonary hypertension

1999 • 21 citations

Effects of chronic dexfenfluramine treatment on pulmonary hemodynamics in dogs.

1996 • 16 citations

Problems of Pulmonary Hypertension in Children with Congenital Cardiac Defects

1988 • 16 citations

The identification of two new urinary metabolites of fenfluramine in man

1983 • 14 citations