Review of postoperative pharmacological infusions in ischemic skin flaps

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Calcitonin gene-related peptide is a potent vasodilator

1985 • 2,050 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

PRINCIPLES OF SOLID-ORGAN PRESERVATION BY COLD STORAGE

1988 • 1,366 citations

Cerebral ischemia. II. The no-reflow phenomenon.

1968 • 1,346 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Endothelium-derived relaxing factor

1988 • 686 citations

The free radical pathology and the microcirculation in the major central nervous system disorders.

1980 • 660 citations

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.

1988 • 421 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

BATTERED BABIES—HOW MANY DO WE MISS?

1970 • 365 citations

Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In Vivo

1983 • 351 citations

LIF: lots of interesting functions

1992 • 341 citations

THE NO-REFLOW PHENOMENON IN EXPERIMENTAL FREE FLAPS

1978 • 334 citations

Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion.

1992 • 296 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Cell Swelling

1973 • 272 citations

Lung Protection by a Thiol-Containing Antioxidant: N-Acetylcysteine

1986 • 266 citations

Ischemia reperfusion injury: A review

1993 • 259 citations

The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps

1983 • 249 citations

Advances in Inflammation Research

1983 • 211 citations

Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.

1990 • 205 citations

DIFFERENTIAL INHIBITION BY LOW-DOSE ASPIRIN OF HUMAN VENOUS PROSTACYCLIN SYNTHESIS AND PLATELET THROMBOXANE SYNTHESIS

1981 • 200 citations

Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey

1982 • 199 citations

Relationship between adenine nucleotide metabolism and irreversible ischemic tissue damage in isolated perfused rat heart.

1979 • 177 citations

Thrombolytic therapy in the eighties

1986 • 177 citations

ADMINISTRATION TO MAN OF UK-37,248-01, A SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE

1981 • 168 citations

Hemodynamics and Viability of Acute Neurovascular Island Skin Flaps in Rats

1980 • 168 citations

P2 purinoceptors on vascular endotheliai cells: physiological significance and transduction mechanisms

1990 • 160 citations

Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited.

1992 • 157 citations

Leukotrienes: their formation and role as inflammatory mediators.

1985 • 144 citations

Free radical defense mechanisms and neutrophil infiltration in postischemic skeletal muscle

1989 • 143 citations

A world survey of anticoagulation practice in clinical microvascular surgery

1982 • 139 citations

The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat

1989 • 134 citations

Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: Injured muscle expresses lif mRNA

1994 • 134 citations

Role of Free Radicals in Lung Injury

1986 • 132 citations

Effect of Allopurinol on the Survival of Hyperemic Island Skin Flaps

1984 • 119 citations

Microvascular changes in acutely ischemic rat muscle.

1969 • 118 citations

Pharmacological Augmentation of Skin Flap Viability: A Hypothesis to Mimic the Surgical Delay Phenomenon or a Wishful Thought

1989 • 118 citations

Potent anti-inflammatory action of calcitonin gene-related peptide

1991 • 117 citations

The use of prostacyclin in the separation from plasma and washing of human platelets

1982 • 115 citations

Pharmacologic Treatment of the Failing Skin Flap

1982 • 115 citations

Mechanisms of endothelium-dependent vascular smooth muscle relaxation

1985 • 115 citations

Endothelium and the vasodilator action of rat calcitonin gene‐related peptide (CGRP)

1987 • 113 citations

Calcitonin gene-related peptide increases survival of a musculocutaneous critical flap in the rat

1987 • 113 citations

STIMULATION OF PROSTACYCLIN RELEASE FROM VESSEL WALL BY BAY g 6575, AN ANTITHROMBOTIC COMPOUND

1979 • 108 citations

The effect of prostacyclin (PGT2) on platelet behaviour. Thrombus formation in vivo and bleeding time.

1979 • 105 citations

Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids.

1992 • 105 citations

Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence.

1991 • 105 citations

PREVENTION OF SKIN FLAP NECROSIS BY A COURSE OF TREATMENT WITH VASODILATOR DRUGS

1978 • 90 citations

Enhancement of Skin-Flap Survival Using Nitroglycerin Ointment

1984 • 87 citations

The Effect of Prostacyclin (PGI2) on Platelet Behaviour. Thrombus Formation in Vivo and Bleeding Time

1979 • 84 citations

Alterations in Cell Function With Ischemia and Shock and Their Correction

1981 • 79 citations

Improved Survival of Island Flaps after Prolonged Ischemia by Perfusion with Superoxide Dismutase

1986 • 78 citations

Progress in microcirculation research

1994 • 78 citations

The influence of selective thromboxane synthetase inhibition with a novel imidazole derivative, UK-38,485, on prostanoid formation in man.

1983 • 77 citations

Mode of action of dipyridamole on human platelets

1979 • 76 citations

Structure and physiology of the slow inward calcium channel

1987 • 71 citations

The Etiologic Role of Free Radicals in Hematoma-Induced Flap Necrosis

1986 • 71 citations

Deferoxamine increases skin flap survival: additional evidence of free radical involvement in ischaemic flap surgery

1986 • 69 citations

Pituitary adenylate cyclase activating polypeptide is a potent vasodilator and oedema potentiator in rabbit skin in vivo

1992 • 65 citations

Induction of permeability change and restoration of membrane permeability barrier in transformed cell cultures*1

1978 • 55 citations

The response of the rabbit rectus femoris muscle to ischemia and reperfusion

1992 • 55 citations

Experimental Transfer of Composite Free Flaps with Microvascular Anastomoses

1973 • 52 citations

Microvascular Surgical Experimental Thrombosis Model

1989 • 42 citations

The importance of topical heparin in microvascular anastomoses: A study in the rat

1980 • 40 citations

PGI2 inhibits ischemia-induced platelet activation and prevents myocardial damage by inhibition of catecholamine release from adrenergic nerve terminals. Evidence for cAMP as common denominator

1981 • 40 citations

Use of streptokinase for the salvage of a free flap: Case report and review of the use of thrombolytic therapy

1987 • 40 citations

Prostacyclin and vascular function: Implications for hypertension and atherosclerosis

1990 • 40 citations

Inhibition of Ischemia-induced Thromboxane Synthesis in Man

1984 • 39 citations

Differentiation of Rat Bone Marrow Cells Into Macrophages Under the Influence of Mouse L929 Cell Supernatant

1991 • 37 citations

Beneficial Effects of Ibuprofen on Experimental Microvascular Free Flaps

1987 • 34 citations

Effect of dextran 70 and saline on thrombus formation following arteriotomy and intimectomy in small arteries

1986 • 34 citations

Preischemic flap washout and its effect on the no-reflow phenomenon.

1985 • 31 citations

Evidence That Calcitonin Gene—Related Peptide Contributes to Inflammation in the Skin and Jointa

1992 • 31 citations

A Comparative Analysis of the Ability of Five Classes of Pharmacological Agents to Augment Skin Flap Survival in Various Models and Species: An Attempt to Standardize Skin Flap Research

1989 • 30 citations

The Effect of Thromboxane Synthetase Inhibition on Tolerance of Skin Flaps to Secondary Ischemia Caused by Venous Obstruction

1990 • 29 citations

Augmentation of Skin Flap Survival with Allopurinol

1987 • 29 citations

PREVENTION OF SKIN FLAP NECROSIS BY A COURSE OF TREATMENT WITH VASOLIDATOR DRUGS

1978 • 28 citations

Combined Prostacyclin and Thromboxane Synthetase Inhibitor UK 38485 in Flap Survival

1986 • 28 citations

The effects of streptokinase on ischemic flaps

1983 • 27 citations

Effect of Intraarterial Prostacyclin on Survival of Skin Flaps in the Pig: Biphasic Response

1984 • 26 citations

Pharmacologic Modification of Blood Flow in the Rabbit Microvasculature with Prostacyclin and Related Drugs

1985 • 26 citations

On the Mechanism by which Antiadrenergic Drugs Increase Survival of Critical Skin Flaps

1983 • 26 citations

Secondary Ischaemia in Rabbit Skin Flaps: The Roles Played by Thromboxane and Free Radicals

1991 • 25 citations

Double Island Latissimus Dorsi Muscle-Skin Flap for Through-and-Through Defects of the Forefoot

1985 • 24 citations

THE VASOPLEGIC EFFECTS OF CHLORPROMAZINE

1963 • 23 citations

The Beneficial Effect of Dextran on Anastomotic Patency and Flap Survival a Strongly Thrombogenic Model

1992 • 23 citations

Drug mixture which improves survival of ischemic rabbit epigastric skin flaps

1994 • 23 citations

Enhancement of ischaemic rabbit skin flap survival with the antioxidant and free-radical scavenger N-acetylcysteine

1991 • 22 citations

Improved Ischemic Island Skin Flap Survival with Continuous Intraarterial Infusion of Adenosine Triphosphate—Magnesium Chloride and Superoxide Dismutase: A Rat Model

1987 • 22 citations

THE ENDOGENOUS NITROVASODILATOR PRODUCED BY THE VASCULAR ENDOTHELIUM

1989 • 20 citations

Augmentation of experimental skin flap survival via postoperative phosphocreatine replacement.

1987 • 20 citations

Prevention of Flap Necrosis by Chlorpromazine

1986 • 20 citations

Glucose Metabolism in Experimental Skin Flaps

1983 • 20 citations

Effect of Ischemic Skin Flap Elevation on Tissue and Plasma Thromboxane A2 and Prostacyclin Production: Modification by Thromboxane Synthetase Inhibition

1988 • 19 citations

Pharmacologic Manipulation of the Microcirculation in Cutaneous and Myocutaneous Flaps in Pigs

1985 • 19 citations

Augmentation of Surviving Flap Area by Intraarterial Vasodilators Administered Through Implantable Pumps

1983 • 19 citations

Calcitonin Gene-related Peptide Delays the No-reflow Phenomenon in the Rat Island Flap

1988 • 18 citations

Prostacyclin and prostanoid modifiers aid ischemic skin flap survival

1991 • 18 citations

The biochemical basis of secondary ischemia

1992 • 18 citations

Vascular injury in dogs during ischemia-reperfusion: improvement with ATP-MgCl2 pretreatment

1988 • 17 citations

Interaction between thromboxane and free radical mechanisms in experimental ischaemic rabbit skin flaps

1990 • 17 citations

Efficacy of Verapamil in the Salvage of Failing Random Skin Flaps

1988 • 16 citations

Early changes in ATP and cyclic AMP levels in experimental critical skin flaps

1981 • 16 citations

Experience with calcium antagonists nitrendipine, diltiazem, and verapamil and β2‐agonist salbutamol in salvaging ischemic skin flaps in rabbits

1991 • 15 citations

Amelioration of secondary ischaemic injury by perfusion with University of Wisconsin (UW) solution in rat skin flaps

1993 • 14 citations

Arachidonic acid metabolism and regulation of blood flow: effect of indomethacin on cutaneous and subcutaneous reactive hyperaemia in humans

1983 • 14 citations

Preischemic Flap Washout and Its Effect on the No-Reflow Phenomenon

1985 • 13 citations

Factors involved in salvaging ischaemic rabbit skin flaps: ATP and free radicals but not throm☐ane

1989 • 13 citations

The Lack of Effect of Nifedipine on Failing Skin Flaps

1985 • 12 citations

Calcitonin gene-related peptide is a venous dilator in conscious rats

1992 • 12 citations

The salvage of rabbit ischaemic epigastric free flaps using the vasodilator calcitonin gene-related peptide

1990 • 11 citations

Regulation of microvascular prostacyclin and thromboxane with inhibitors or arachidonic acid metabolism

1987 • 11 citations

Amelioration of free radical-mediated postischemic reperfusion injury by iron chelation in skin flaps

1986 • 11 citations

The Influence of the Calcium Channel Blocker Nimodipine on Flap Survival

1989 • 10 citations

EFFECT OF A THROMBOXANE SYNTHETASE INHIBITOR UK‐38, 485 ON THE TOLERANCE OF SKIN FLAPS OF PRIMARY ISCHAEMIA

1990 • 10 citations

Infusions of a novel calcitonin gene-related peptide (CGRP) derivative at the time of reperfusion to salvage ischaemic rabbit skin flaps.

1993 • 10 citations

The Beneficial Effect of Chlorpromazine on Dorsal Skin Flap Survival

1989 • 10 citations

Prostacyclin Formation in Delayed Pig Flank Flaps

1984 • 9 citations

Interrelationships between prostanoids and skin flap survival: A review

1991 • 9 citations

Effect of the vasodilator peptides calcitonin gene-related peptide and atriopeptin on rabbit microcvascular blood flow. Preliminary communication

1988 • 4 citations

Rigor of small human vessels

1985 • 3 citations

The mechanisms of flap oedema following free transfer in man and its control with salbutamol

1984 • 2 citations