Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

MicroRNAs

2004 • 33,206 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

A microRNA expression signature of human solid tumors defines cancer gene targets

2006 • 5,638 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Combinatorial microRNA target predictions

2005 • 4,543 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

2007 • 3,708 citations

Human MicroRNA Targets

2004 • 3,702 citations

The impact of microRNAs on protein output

2008 • 3,546 citations

Widespread changes in protein synthesis induced by microRNAs

2008 • 3,372 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

The role of site accessibility in microRNA target recognition

2007 • 2,362 citations

Hypoxia in cancer: significance and impact on clinical outcome

2007 • 2,062 citations

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

2006 • 1,494 citations

Small non-coding RNAs in animal development

2008 • 1,356 citations

Cancer's Molecular Sweet Tooth and the Warburg Effect

2006 • 1,178 citations

microRNA target predictions in animals

2006 • 1,093 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

A MicroRNA Signature of Hypoxia

2006 • 1,043 citations

Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

2005 • 907 citations

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

2008 • 874 citations

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

2008 • 647 citations

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

2006 • 605 citations

Mechanisms of microRNA-mediated gene regulation in animal cells

2007 • 575 citations

Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

2002 • 508 citations

How Do MicroRNAs Regulate Gene Expression?

2007 • 472 citations

Hypoxic gene expression and metastasis

2004 • 470 citations

Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition

2006 • 447 citations

The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

2002 • 438 citations

Hypoxia-driven selection of the metastatic phenotype

2007 • 400 citations

Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression

2001 • 373 citations

Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer

2008 • 370 citations

Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers

2007 • 366 citations

A biochemical approach to identifying microRNA targets

2007 • 364 citations

miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer

2008 • 346 citations

Isolation of microRNA targets by miRNP immunopurification

2007 • 290 citations

MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

2009 • 280 citations

Identification of Human microRNA Targets From Isolated Argonaute Protein Complexes

2007 • 276 citations

Hypoxia, gene expression, and metastasis

2007 • 271 citations

BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1α

2003 • 256 citations

Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1α

2005 • 226 citations

Hypoxia induces microRNA miR‐210 in vitro and in vivo

2008 • 190 citations

Transcriptional Profiling of Human Cord Blood CD133+ and Cultured Bone Marrow Mesenchymal Stem Cells in Response to Hypoxia

2006 • 167 citations

Human Growth Hormone-regulated HOXA1 Is a Human Mammary Epithelial Oncogene

2003 • 145 citations

Multiple roles for Pur-α in cellular and viral regulation

2009 • 124 citations

p21^Cip1 and p27^Kip1Regulate Cell Cycle Reentry after Hypoxic Stress but Are Not Necessary for Hypoxia-Induced Arrest

2001 • 107 citations

Regulation of cardiac Na+–Ca2+ exchanger activity by protein kinase phosphorylation—Still a paradox?

2008 • 72 citations

Functional Analysis of p53 Binding under Differential Stresses

2006 • 62 citations