The heart remembers

Atrial Fibrillation Begets Atrial Fibrillation

1995 • 3,388 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation

1997 • 809 citations

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.

1991 • 731 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Systemic arterial baroreceptor reflexes

1976 • 650 citations

Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.

1992 • 611 citations

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

1996 • 606 citations

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

1997 • 548 citations

Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity

1991 • 499 citations

Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.

1993 • 439 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

Electrotonic modulation of the T wave and cardiac memory

1982 • 416 citations

Sudden cardiac death in heart failure. The role of abnormal repolarization.

1994 • 415 citations

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes

1995 • 412 citations

The determination and the significance of the areas of the ventricular deflections of the electrocardiogram

1934 • 412 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Redistribution of myocardial fiber strain and blood flow by asynchronous activation

1990 • 383 citations

beta-Adrenergic stimulation of phospholamban phosphorylation and Ca2+-ATPase activity in guinea pig ventricles.

1983 • 348 citations

Contraction-excitation feedback in myocardium. Physiological basis and clinical relevance.

1982 • 304 citations

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

1988 • 265 citations

Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake.

1984 • 255 citations

A molecular mechanism for long-term sensitization in Aplysia

1987 • 234 citations

Mechanical Transduction of Nitric Oxide Synthesis in the Beating Heart

1997 • 233 citations

Refractory Period of the Dog's Ventricular Myocardium Following Sudden Changes in Frequency

1969 • 188 citations

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

1997 • 185 citations

Developmental sequelae of fixed-rate ventricular pacing in the immature canine heart: An electrophysiologic, hemodynamic, and histopathologic evaluation

1990 • 184 citations

Electrocardiographic changes subsequent to artificial ventricular depolarization.

1969 • 167 citations

Cell Adhesion Molecules, CREB, and the Formation of New Synaptic Connections

1996 • 166 citations

Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method.

1976 • 155 citations

The Mechanism of Intermittent Bundle Branch Block: Relationship to Prolonged Recovery, Hypopolarization and Spontaneous Diastolic Depolarization

1973 • 153 citations

REPETITIVE PAROXYSMAL TACHYCARDIA

1947 • 149 citations

Intracellular Injection of cAMP Induces a Long-Term Reduction of Neuronal K ⁺ Currents

1988 • 134 citations

Decoding calcium signals by multifunctional CaM kinase

1992 • 131 citations

Slow and long-lasting modulation of myocardial repolarization produced by ectopic activation in isolated rabbit hearts. Evidence for cardiac "memory".

1989 • 129 citations

Neuropeptides, Adenylyl Cyclase, and Memory Storage

1995 • 122 citations

Evolution and Resolution of Long-term Cardiac Memory

1998 • 117 citations

Genes, nerve cells, and the remembrance of things past

1989 • 99 citations

T wave changes persisting after ventricular pacing in canine heart are altered by 4-aminopyridine but not by lidocaine. Implications with respect to phenomenon of cardiac 'memory'.

1992 • 99 citations

Enhancement of sympathetic nerve activity by single premature ventricular beats in humans

1989 • 98 citations

A hemodynamic load in vivo induces cardiac expression of the cellular oncogene, c-myc

1987 • 94 citations

Persistent T-wave changes after alteration of the ventricular activation sequence. New insights into cellular mechanisms of 'cardiac memory'.

1993 • 91 citations

Protein kinase C inhibits Ca2+ accumulation in cardiac sarcoplasmic reticulum.

1990 • 90 citations

Myocardial stretch stimulates phosphatidylinositol turnover.

1989 • 88 citations

Increased cyclic AMP content accelerates protein synthesis in rat heart.

1989 • 75 citations

A Characteristic Precordial Repolarization Abnormality with Intermittent Left Bundle-Branch Block

1978 • 71 citations

Stretch-induced Inositol Trisphosphate and Tetrakisphosphate Production in Rat Cardiomyocytes

1993 • 68 citations

The Clinical Significance of Postextrasystolic T-Wave Changes

1952 • 65 citations

Wolff-Parkinson-White syndrome: T wave abnormalities during normal pathway conduction

1981 • 62 citations

T Wave “Memory”: Possible Causal Relationship to Stress‐Induced Changes in Cardiac Ion Channels?

1992 • 60 citations

Alterations in the form of the T waves with changes in heart rate

1944 • 59 citations

Constitutive presence of a catalytic fragment of protein kinase C epsilon in a small cell lung carcinoma cell line.

1992 • 59 citations

Transient Outward Currents in Subendocardial Purkinje Myocytes Surviving in the Infarcted Heart

1995 • 57 citations

T-Wave Abnormalities of Intermittent Left Bundle-Branch Block

1978 • 53 citations

Coronary flow as a determinant of c-myc and c-fos proto-oncogene expression in an isolated adult rat heart

1988 • 50 citations

Post-paroxysmal tachycardia syndrome.

1969 • 46 citations

Responses of sympathetic nerves to programmed ventricular stimulation

1987 • 44 citations

Stimuli that produce sensitization lead to elevation of cyclic AMP levels in tail sensory neurons ofAplysia

1986 • 40 citations

Pacemaker-Induced Electrocardiographic Changes Simulating Myocardial Infarction

1973 • 38 citations

Neuronal Ca2+/Calmodulin-Dependent Protein Kinases

1992 • 36 citations

Intermittent left bundle branch block

1973 • 35 citations

Electrotonic modulation of the T wave

1982 • 29 citations

Modulation of Atrial Repolarization by Site of Pacing in the Isolated Rabbit Heart

1996 • 29 citations

Sympathetic nervous system activation in postextrasystolic potentiation: Role of catecholamine release in enhancement of ventricular function

1984 • 20 citations

Local Functional and Structural Changes in the Myocardium During Ventricular Pacing

1996 • 7 citations

Intermittent Left Bundle Branch Block:

1996 • 3 citations