The Human Rho-GEF Trio and Its Target GTPase RhoG Are Involved in the NGF Pathway, Leading to Neurite Outgrowth

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

1996 • 452 citations

UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans

1998 • 319 citations

Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila

2000 • 315 citations

Essential Roles of Drosophila RhoA in the Regulation of Neuroblast Proliferation and Dendritic but Not Axonal Morphogenesis

2000 • 291 citations

Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila

1999 • 289 citations

The Guanine Nucleotide Exchange Factor Trio Mediates Axonal Development in the Drosophila Embryo

2000 • 214 citations

The Drosophila Trio Plays an Essential Role in Patterning of Axons by Regulating Their Directional Extension

2000 • 201 citations

Dosage-Sensitive, Reciprocal Genetic Interactions between the Abl Tyrosine Kinase and the Putative GEF trio Reveal trio 's Role in Axon Pathfinding

2000 • 188 citations

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG

2000 • 166 citations

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs

1998 • 162 citations

The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo

1998 • 140 citations

Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells

2000 • 138 citations

Axon guidance: GTPases help axons reach their targets

1998 • 76 citations

Kinectin Is a Key Effector of RhoG Microtubule-Dependent Cellular Activity

2001 • 72 citations

The DH Protein Family, Exchange Factors for Rho-Like GTPases

1999 • 53 citations

Improved methods for preserving macromolecular structures and visualizing them by fluorescence and scanning electron microscopy.

1995 • 41 citations

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