Penicillin binding protein 2x as a major contributor to intrinsic β‐lactam resistance of Streptococcus pneumoniae

Properties of the Penicillin‐Binding Proteins of Escherichia coli K12

1977 • 645 citations

Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

1989 • 404 citations

Genetics and Molecular Biology of Streptococci, Lactococci, and Enterococci

1991 • 352 citations

Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin‐resistant clinical isolates of Streptococcus pneumoniae

1991 • 280 citations

Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniae

1980 • 271 citations

Penicillin-Sensitive Enzymes in Peptidoglycan Biosynthesis

1984 • 251 citations

Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae

1980 • 224 citations

The diversity of the catalytic properties of class A β-lactamases

1990 • 169 citations

Identification of a streptococcal penicillin-binding protein that reacts very slowly with penicillin

1983 • 162 citations

Nucleotide sequences of the pbpX genes encoding the penicillin‐binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime‐resistant mutant, C506

1989 • 120 citations

Pneumococcal proteins and the pathogenesis of disease caused by Streptococcus pneumoniae

1992 • 111 citations

Modification of penicillin-binding proteins as mechanisms of beta-lactam resistance

1986 • 109 citations

Chromogenic depsipeptide substrates for β-lactamases and penicillin-sensitive <scp>dd</scp>-peptidases

1990 • 107 citations

In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae

1980 • 100 citations

Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins

1991 • 97 citations

Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae

1991 • 93 citations

Penicillin‐binding proteins in β‐lactam‐resistant laboratory mutants of Streptococcus pneumoniae

1987 • 77 citations

Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with β-lactams

1993 • 74 citations

Purification of Penicillin‐Binding Protein 3 from Streptococcus pneumoniae

1982 • 48 citations

Identification of the binding protein which may be the target of penicillin action in Bacillus megaterium

1978 • 46 citations

The chemistry of beta lactams

1992 • 41 citations

Purification and Characterization of the Penicillin-Binding Protein that is the Lethal Target of Penicillin in Bacillus megaterium and Bacillus licheniformis. Protein Exchange and Complex Stability

1978 • 36 citations

Bacillus megaterium resistance to cloxacillin accompanied by a compensatory change in penicillin binding proteins

1979 • 36 citations

Antibodies against the benzylpenicilloyl moiety as a probe for penicillin-binding proteins

1986 • 33 citations

Penicillin‐binding protein 2x of Streptococcus pneumoniae

1992 • 26 citations

The mechanism of action of <scp>dd</scp>-peptidases: the role of tyrosine-159 in the Streptomyces R61 <scp>dd</scp>-peptidase

1993 • 23 citations