Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

2000 • 1,157 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

2009 • 869 citations

The neutrophil as a cellular source of chemokines

2000 • 775 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Transgenic mice with hematopoietic and lymphoid specific expression of Cre

2003 • 713 citations

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 • 686 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

2009 • 439 citations

Syk Is Required for Integrin Signaling in Neutrophils

2002 • 419 citations

JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells

2004 • 418 citations

Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide.

1986 • 415 citations

Three Different Neutrophil Subsets Exhibited in Mice with Different Susceptibilities to Infection by Methicillin-Resistant Staphylococcus aureus

2004 • 398 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

2006 • 359 citations

Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice

1998 • 357 citations

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

2005 • 317 citations

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

2003 • 300 citations

Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils.

1993 • 287 citations

Pattern Recognition by TREM-2: Binding of Anionic Ligands

2003 • 270 citations

Pattern recognition: recent insights from Dectin-1

2009 • 270 citations

The molecular basis of fibronectin‐mediated bacterial adherence to host cells

2004 • 260 citations

Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators

1994 • 232 citations

Adhesion-Dependent Degranulation of Neutrophils Requires the Src Family Kinases Fgr and Hck

1999 • 231 citations

Integrin Signalling in Neutrophils and Macrophages

1999 • 226 citations

Vav GEFs are required for β2 integrin-dependent functions of neutrophils

2004 • 220 citations

Src and Syk kinases: key regulators of phagocytic cell activation

2005 • 209 citations

Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving β 2 integrins and selectin ligands

2002 • 193 citations

Long-term follow-up and outcome of 39 patients with chronic granulomatous disease

2000 • 193 citations

Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

2006 • 187 citations

Of Man and Mouse: Leukocyte and Endothelial Adhesion Molecule Deficiencies

1999 • 159 citations

Phagocyte immunodeficiencies and their infections

2004 • 159 citations

The shedding activity of ADAM17 is sequestered in lipid rafts

2006 • 137 citations

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice

2007 • 121 citations

Mac-1 Signaling via Src-Family and Syk Kinases Results in Elastase-Dependent Thrombohemorrhagic Vasculopathy

2006 • 112 citations

p40 Is Phosphorylated on Threonine 154 and Serine 315 during Activation of the Phagocyte NADPH Oxidase

1998 • 109 citations

Role for Plastin in Host Defense Distinguishes Integrin Signaling from Cell Adhesion and Spreading

2003 • 101 citations

CARD9 Signaling in the Innate Immune Response

2008 • 99 citations

The Lyn Tyrosine Kinase Negatively Regulates Neutrophil Integrin Signaling

2003 • 98 citations

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks

2008 • 89 citations

Convergence of immunoreceptor and integrin signaling

2007 • 84 citations

Distinct roles for Syk and ZAP-70 during early thymocyte development

2007 • 82 citations

Septic Shock and Acute Lung Injury in Rabbits with Peritonitis

2001 • 79 citations

Phagocyte C3-mediated attachment and internalization: Flow cytometric studies using a fluorescence quenching technique

1984 • 76 citations

Increased TLR responses in dendritic cells lacking the ITAM‐containing adapters DAP12 and FcRγ

2007 • 59 citations

Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles

2005 • 55 citations

Increased TLR Responses in Dendritic Cells Lacking the Itam‐Containing Adapters Dap12 and FcRγ

2008 • 35 citations

ITAM Signaling by Vav Family Rho Guanine Nucleotide Exchange Factors Regulates Interstitial Transit Rates of Neutrophils In Vivo

2009 • 30 citations