Criteria for the Validation of Surrogate Endpoints in Randomized Experiments

SAS System for Mixed Models

1996 • 10,609 citations

Categorical Data Analysis

1991 • 9,374 citations

Surrogate endpoints in clinical trials: Definition and operational criteria

1989 • 1,929 citations

Surrogate End Points in Clinical Trials: Are We Being Misled?

1996 • 1,592 citations

Statistical validation of intermediate endpoints for chronic diseases

1992 • 629 citations

ESTIMATING THE PROPORTION OF TREATMENT EFFECT EXPLAINED BY A SURROGATE MARKER

1997 • 483 citations

Correlated binary regression using a quadratic exponential model

1990 • 481 citations

A Class of Bivariate Distributions

1965 • 465 citations

Modelling Progression of CD4-Lymphocyte Count and Its Relationship to Survival Time

1994 • 385 citations

Families of Bivariate Distributions

1973 • 359 citations

Global Cross-Ratio Models for Bivariate, Discrete, Ordered Responses

1986 • 284 citations

Marginal Modeling of Correlated Ordinal Data Using a Multivariate Plackett Distribution

1994 • 279 citations

Surrogate endpoints in clinical trials: Cardiovascular diseases

1989 • 235 citations

CD4+ Lymphocytes Are an Incomplete Surrogate Marker for Clinical Progression in Persons with Asymptomatic HIV Infection Taking Zidovudine

1993 • 197 citations

Surrogate and auxiliary endpoints in clinical trials, with potential applications in cancer and aids research

1994 • 167 citations

Surrogate endpoints: A basis for a rational approach

1992 • 163 citations

Validation of Intermediate End Points in Cancer Research

1990 • 156 citations

Surrogate endpoints in clinical trials: Cancer

1989 • 154 citations

Perspective: Validating Surrogate Markers--Are We Being Naive?

1997 • 125 citations

Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine.

1991 • 121 citations

Modeling the relationship between survival and CD4 lymphocytes in patients with AIDS and AIDS-related complex.

1993 • 100 citations

Does chemotherapy improve survival in advanced breast cancer? A statistical overview

1988 • 90 citations

Evaluating the role of CD4‐lymphocyte counts as surrogate endpoints in human immunodeficiency virus clinical trials

1993 • 84 citations

On the use of laboratory markers as surrogates for clinical endpoints in the evaluation of treatment for HIV infection.

1990 • 48 citations

Fieller's theorem vs. The delta method for significance intervals for ratios

1975 • 27 citations