Mechanisms of immune tolerance relevant to food allergy

The gut microbiota shapes intestinal immune responses during health and disease

2009 • 4,497 citations

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

2004 • 4,044 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Food Allergy

1951 • 2,639 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

2013 • 2,289 citations

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

2010 • 1,973 citations

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

2007 • 1,890 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

Intestinal barrier function: Molecular regulation and disease pathogenesis

2009 • 1,483 citations

Anatomical basis of tolerance and immunity to intestinal antigens

2003 • 1,365 citations

Allergy development and the intestinal microflora during the first year of life

2001 • 1,189 citations

Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas

2007 • 1,096 citations

Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells

2004 • 1,060 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

2007 • 968 citations

Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

2006 • 963 citations

Food allergy

2009 • 921 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy

2008 • 784 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

2007 • 763 citations

Dendritic cells in intestinal immune regulation

2008 • 745 citations

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

2008 • 721 citations

Clinical efficacy and immune regulation with peanut oral immunotherapy

2009 • 697 citations

Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells

2006 • 676 citations

Food Allergy Among Children in the United States

2009 • 674 citations

Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells

2004 • 629 citations

Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand

2007 • 614 citations

Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans

2008 • 588 citations

Oral tolerance

2005 • 573 citations

A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy

2008 • 563 citations

The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review

2010 • 523 citations

Sensing the outside world: TSLP regulates barrier immunity

2010 • 519 citations

Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy

2004 • 492 citations

Time trends in allergic disorders in the UK

2006 • 476 citations

Diagnosing and Managing Common Food Allergies

2010 • 459 citations

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

2008 • 454 citations

Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis

2009 • 452 citations

Breast milk–mediated transfer of an antigen induces tolerance and protection from allergic asthma

2008 • 428 citations

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

2008 • 426 citations

Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation

2008 • 406 citations

Oral tolerance and its relation to food hypersensitivities

2005 • 391 citations

Oral peanut immunotherapy in children with peanut anaphylaxis

2010 • 383 citations

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

2008 • 363 citations

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

2010 • 352 citations

Microbiology in the post-genomic era

2008 • 350 citations

Household peanut consumption as a risk factor for the development of peanut allergy

2009 • 350 citations

Dietary prevention of allergic diseases in infants and small children

2008 • 313 citations

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

2007 • 302 citations

T cell anergy and costimulation

2003 • 299 citations

Timing of Initial Exposure to Cereal Grains and the Risk of Wheat Allergy

2006 • 295 citations

IL-9– and mast cell–mediated intestinal permeability predisposes to oral antigen hypersensitivity

2008 • 279 citations

Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis

2010 • 275 citations

Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

2008 • 265 citations

Oral tolerance, food allergy, and immunotherapy: Implications for future treatment

2008 • 263 citations

The role of protein digestibility and antacids on food allergy outcomes

2008 • 261 citations

Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis

2010 • 258 citations

Severe Food Allergy as a Variant of IPEX Syndrome Caused by a Deletion in a Noncoding Region of the FOXP3 Gene

2007 • 254 citations

Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein

2009 • 246 citations

Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK

2009 • 236 citations

Immune Responses to Fed Protein Antigens in Mice. 3. Systemic Tolerance or Priming Is Related to Age at Which Antigen Is First Encountered

1984 • 221 citations

Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development

2010 • 215 citations

Successful oral tolerance induction in severe peanut allergy

2009 • 203 citations

Human Liver Dendritic Cells Promote T Cell Hyporesponsiveness

2009 • 198 citations

Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.

1998 • 186 citations

Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 4 to 15 years

1994 • 172 citations

Cytokines (IL-1β, IL-6, TNF-α, TGF-β1, and TGF-β2) and Prostaglandin E2 in Human Milk during the First Three Months Postpartum

1999 • 161 citations

Gastrointestinal Dendritic Cells Promote Th2 Skewing via OX40L

2008 • 160 citations

Human milk–specific mucosal lymphocytes of the gastrointestinal tract display a TH2 cytokine profile

2002 • 155 citations

High intestinal IgA associates with reduced risk of IgE‐associated allergic diseases

2009 • 153 citations

Reduced transforming growth factor‐β1‐producing T cells in the duodenal mucosa of children with food allergy

2003 • 149 citations

Intestinal permeability in patients with adverse reactions to food

2006 • 141 citations

Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1

2010 • 123 citations

Retinoic acid production by intestinal dendritic cells and its role in T-cell trafficking

2008 • 119 citations

Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance

2007 • 116 citations

Epithelia: lymphocyte interactions in the gut

2007 • 113 citations

Update on mucosal immunoglobulin A in gastrointestinal disease

2010 • 107 citations

Milk-Derived Transforming Growth Factor-β and the Infant Immune Response

2010 • 105 citations

Oral Tolerance: Overview and Historical Perspectives

2004 • 97 citations

The yin and yang of intestinal epithelial cells in controlling dendritic cell function

2007 • 92 citations

Role of TLR4 in allergic sensitization to food proteins in mice

2005 • 89 citations

From the diet to the nucleus: Vitamin A and TGF-β join efforts at the mucosal interface of the intestine

2008 • 88 citations

Sequential Role of Plasmacytoid Dendritic Cells and Regulatory T Cells in Oral Tolerance

2009 • 88 citations

NKT cells in mucosal immunity

2009 • 79 citations

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

2010 • 71 citations

Effects of Transforming Growth Factor-Beta and Formula Feeding on Systemic Immune Responses to Dietary β-Lactoglobulin in Allergy-Prone Rats

2006 • 69 citations

Vitamin A rewrites the ABCs of oral tolerance

2008 • 68 citations

Maternal peanut exposure during pregnancy and lactation reduces peanut allergy risk in offspring

2009 • 64 citations

Hypersensitivity and oral tolerance in the absence of a secretory immune system

2009 • 62 citations

New‐onset post‐transplantation food allergy in children – Is it attributable only to the immunosuppressive protocol?

2009 • 57 citations

Review Article: Probiotics for allergic diseases: Realities and myths

2009 • 50 citations

Allergic disease: understanding howin uteroevents set the scene

2010 • 41 citations

Soothing signals: transplacental transmission of resistance to asthma and allergy

2009 • 34 citations