Update on mucosal immunoglobulin A in gastrointestinal disease

A human gut microbial gene catalogue established by metagenomic sequencing

2010 • 10,392 citations

The gut microbiota shapes intestinal immune responses during health and disease

2009 • 4,497 citations

Identification of tissue transglutaminase as the autoantigen of celiac disease

1997 • 2,028 citations

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

2009 • 1,340 citations

Microbes in Gastrointestinal Health and Disease

2008 • 1,297 citations

The fundamental basis of inflammatory bowel disease

2007 • 1,277 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis

2007 • 773 citations

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

2002 • 580 citations

Protective Effect of Rotavirus VP6-Specific IgA Monoclonal Antibodies That Lack Neutralizing Activity

1996 • 487 citations

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

2009 • 485 citations

Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation

2002 • 481 citations

Appendectomy and Protection against Ulcerative Colitis

2001 • 471 citations

Mucosal Immunity: Induction, Dissemination, and Effector Functions

2009 • 454 citations

Selected loss of tolerance evidenced by Crohn's disease–associated immune responses to auto- and microbial antigens

2002 • 438 citations

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

1996 • 437 citations

Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins

1984 • 415 citations

Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties

2005 • 414 citations

Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut

1995 • 395 citations

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice

1999 • 395 citations

A three-tiered view of the role of IgA in mucosal defense

1993 • 374 citations

In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies

2004 • 345 citations

Multiple facets of intestinal permeability and epithelial handling of dietary antigens

2010 • 343 citations

Mucosal and Invading Bacteria in Patients with Inflammatory Bowel Disease Compared with Controls

2002 • 337 citations

Intestinal Macrophages Lack CD14 and CD89 and Consequently Are Down-Regulated for LPS- and IgA-Mediated Activities

2001 • 319 citations

Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease

2007 • 285 citations

Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice.

1996 • 265 citations

In vivo IgA coating of anaerobic bacteria in human faeces.

1996 • 219 citations

Function of Mucosa-Associated Lymphoid Tissue in Antibody Formation

2010 • 218 citations

Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis

2010 • 209 citations

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis

2010 • 204 citations

The J Chain Is Essential for Polymeric Ig Receptor-Mediated Epithelial Transport of IgA

2001 • 199 citations

Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood

2009 • 175 citations

Secretory IgA: Arresting Microbial Pathogens at Epithelial Borders

2010 • 168 citations

B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue

2002 • 157 citations

Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon

1987 • 155 citations

Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease

2006 • 155 citations

Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease

1996 • 153 citations

Segmented filamentous bacteria take the stage

2010 • 152 citations

Anti‐inflammatory activity of human IgA antibodies and their Fabα fragments: inhibition of IgG‐mediated complement activation

1989 • 149 citations

A Mucosal IgA-Mediated Excretory Immune System In Vivo

2001 • 146 citations

Human serum IgA downregulates the release of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) in human monocytes

1994 • 131 citations

The B-Cell System in Inflammatory Bowel Disease

2006 • 128 citations

Food allergy: separating the science from the mythology

2010 • 122 citations

Human eosinophils express a receptor for secretory component. Role in secretory IgA‐dependent activation

1995 • 118 citations

Role of Secretory Immunoglobulin a and Secretory Component in the Protection of Mucosal Surfaces

2010 • 116 citations

Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)

1997 • 116 citations

A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy

2003 • 111 citations

Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study

2002 • 111 citations

Immune responses of specific pathogen-free and gnotobiotic mice to antigens of indigenous and nonindigenous microorganisms

1975 • 109 citations

Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)

1997 • 103 citations

Secretory Antibody Formation: Conserved Binding Interactions between J Chain and Polymeric Ig Receptor from Humans and Amphibians

2007 • 100 citations

Specific and Nonspecific Humoral Defense Factors-in the Epithelium of Normal and Inflamed Gastric Mucosa

1984 • 95 citations

Epithelial Expression of HLA, Secretory Component (Poly‐Ig Receptor), and Adhesion Molecules in the Human Alimentary Tracta

1992 • 91 citations

Responses to self and non-self intestinal microflora in health and inflammatory bowel disease

1997 • 91 citations

Dissociation between systemic and mucosal humoral immune responses in coeliac disease.

1991 • 87 citations

Contribution of Plasma‐Derived Molecules to Mucosal Immune Defence, Disease and Repair in the Airways

1998 • 86 citations

Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue.

1984 • 85 citations

Secretory antibodies reduce systemic antibody responses against the gastrointestinal commensal flora

2007 • 82 citations

Interaction with Secretory Component Stimulates Effector Functions of Human Eosinophils But Not of Neutrophils

1998 • 80 citations

Intestinal Permeability in Pediatric Gastroenterology

1992 • 78 citations

Appendectomy and Tonsillectomy in Patients with Inflammatory Bowel Disease

1995 • 78 citations

Role of Appendix and Spleen in Experimental Colitis

2001 • 73 citations

Immunoglobulin A Anti‐tissue Transglutaminase Antibody Deposits in the Small Intestinal Mucosa of Children With No Villous Atrophy

2008 • 70 citations

Distribution of immunoglobulin producing cells is different in normal human appendix and colon mucosa.

1986 • 68 citations

Immunological Response of Mice to Members of the Autochthonous Intestinal Microflora

1972 • 63 citations

Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis.

1997 • 63 citations

The changing immunological paradigm in coeliac disease

2006 • 62 citations

Hypersensitivity and oral tolerance in the absence of a secretory immune system

2009 • 62 citations

Gut mucosal response to food antigens in Crohn's disease

2002 • 61 citations

Expression and Modulation of the Human Immunoglobulin A Fc Receptor (CD89) and the FcR γ Chain on Myeloid Cells in Blood and Tissue

2003 • 59 citations

Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium‐induced colitis

2006 • 57 citations

Quantitative distribution of immunoglobulin-producing cells in gastric mucosa: relation to chronic gastritis and glandular atrophy.

1986 • 56 citations

J-chain expression is more prominent in immunoglobulin A2 than in immunoglobulin A1 colonic immunocytes and is decreased in both subclasses associated with inflammatory bowel disease

1988 • 55 citations

IgA triggers tumor necrosis factor α secretion by monocytes: A study in normal subjects and patients with alcoholic cirrhosis

1991 • 54 citations

Inhibition of Receptor-Dependent and Receptor-Independent Generation of the Respiratory Burst in Human Neutrophils and Monocytes by Human Serum IgA

1994 • 51 citations

Local IgA subclass alterations in ulcerative colitis and Crohn's disease of the colon.

1987 • 51 citations

IgG subclass distribution in serum and rectal mucosa of monozygotic twins with or without inflammatory bowel disease.

1992 • 50 citations

Immunoglobulin- and J chain-producing cells associated with lymphoid follicles in the human appendix, colon and ileum, including Peyer's patches.

1986 • 48 citations

Essential role of Peyer's patches in the development of Helicobacter-induced gastritis

2007 • 48 citations

Mechanisms of gastrointestinal reactions to food

1997 • 42 citations

Anti-endomysial antibody of IgG1 isotype detection strongly increases the prevalence of coeliac disease in patients affected by type I diabetes mellitus

2005 • 39 citations

Nonimmune macromolecular complexes of Ig in human gut lumen. Probable enhancement of antibody functions.

1993 • 38 citations

Terminally differentiated human intestinal B cells. J chain expression of IgA and IgG subclass-producing immunocytes in the distal ileum compared with mesenteric and peripheral lymph nodes

1990 • 36 citations

Visualization of Transepithelial Passage of the Immunogenic 33-Residue Peptide from α-2 Gliadin in Gluten-Sensitive Macaques

2010 • 36 citations

CCL28 Is Increased in Human Helicobacter pylori -Induced Gastritis and Mediates Recruitment of Gastric Immunoglobulin A-Secreting Cells

2008 • 32 citations

Expression of the LFA‐1 β2 Integrin (CD11a/CD18) and ICAM‐1 (CD54) in Normal and Coeliac Small Bowel Mucosa

1991 • 32 citations

Intestinal and serum antibody in coeliac disease: a comparison using ELISA.

1986 • 30 citations

Secretory immunity in celiac disease: Cellular expression of immunoglobulin a subclass and joining chain

1990 • 29 citations

Production of antibodies to gliadin in intestinal mucosa of patients with coeliac disease: a study at the single cell level.

1989 • 25 citations

Production of Antibodies to Gliadin by Peripheral Blood Lymphocytes in Children with Celiac Disease: The Use of an Enzyme-Linked Immunospot Technique for Screening and Follow-Up

1997 • 23 citations

Jejunal immunoglobulin and antigliadin antibody secretion in adult coeliac disease.

1990 • 22 citations

The IgA subclass distributions of endomysium and gliadin antibodies in human sera are different

1996 • 16 citations

Increased Mucosal Production of Monomeric IgA1 but No IgA1 Protease Activity in Helicobacter pylori Gastritis

1999 • 14 citations

Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease

1992 • 11 citations

Local immunoglobulin production is different in gastritis associated with dermatitis herpetiformis and simple gastritis.

1987 • 7 citations