Carcinogenic, teratogenic and mutagenic effects of cadmium

Biochemical Effects of Mercury, Cadmium, and Lead

1972 • 1,464 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides, and and nucleotides

1971 • 748 citations

The chemistry, biochemistry and biology of cadmium

1980 • 646 citations

Interaction of metal ions with polynucleotides and related compounds. XII. The relative effect of various metal ions on DNA helicity

1968 • 595 citations

Progress in Genetic Toxicology

1978 • 581 citations

Detection of chemical mutagens by the dominant lethal assay in the mouse

1972 • 572 citations

Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 523 citations

Infidelity of DNA Synthesis in Vitro: Screening for Potential Metal Mutagens or Carcinogens

1976 • 434 citations

Mutagenic activities of metal compounds in bacteria

1975 • 400 citations

Metallothioneins and their role in the metabolism and toxicity of metals

1978 • 400 citations

Toxic effects of cadmium: A review

1971 • 329 citations

Rec assay and mutagenicity studies on metal compounds

1980 • 323 citations

Effect of Cadmium Salts on Testicular Tissue

1956 • 323 citations

THE MUTAGENIC ACTIVITY OF 61 AGENTS AS DETERMINED BY THE MICRONUCLEUS, SALMONELLA, AND SPERM ABNORMALITY ASSAYS

1979 • 283 citations

Nucleic Acids and Metals

1959 • 270 citations

Binding of cadmium ions by rat liver and kidney

1972 • 261 citations

Toxic Effects of Trace Elements on the Reproduction of Mice and Rats

1971 • 256 citations

Mutagenicity of chromates in bacteria and its relevance to chromate carcinogenesis

1974 • 244 citations

CANCER MORTALITY AMONG CADMIUM PRODUCTION WORKERS

1976 • 236 citations

Association of cadmium with renal cancer

1976 • 221 citations

CADMIUM AND PROSTATIC CARCINOMA

1967 • 210 citations

Exposure and accumulation of cadmium in populations from Japan, the United States, and Sweden

1979 • 204 citations

Placental transfer of lead, mercury, cadmium, and carbon monoxide in women

1978 • 199 citations

Evaluation of the carcinogenicity of chemicals: a review of the Monograph Program of the International Agency for Research on Cancer (1971 to 1977).

1978 • 186 citations

Cadmium Proteinuria—The Health of Battery Workers Exposed to Cadmium Oxide Dust

1965 • 181 citations

Carcinogenic effects of metals.

1978 • 178 citations

Cadmium-Induced Interstitial Cell Tumors in Rats and Mice and Their Prevention by Zinc<xref ref-type="fn" rid="FN2">2</xref>

1963 • 175 citations

Metabolism and Toxicity of Cadmium, Mercury, and Lead in Animals: A Review

1975 • 174 citations

Cytological Reactions Induced by Inorganic Salt Solutions

1945 • 173 citations

Distribution of Cadmium Among Protein Fractions of Mouse Liver¹)

1971 • 167 citations

VASCULAR CHANGES AT SITES OF OESTROGEN BIOSYNTHESIS PRODUCED BY PARENTERAL INJECTION OF CADMIUM SALTS: THE DESTRUCTION OF PLACENTA BY CADMIUM SALTS

1964 • 163 citations

Chromium, Lead, Cadmium, Nickel and Titanium in Mice: Effect on Mortality, Tumors and Tissue Levels

1964 • 163 citations

Genetic Analysis of Resistance to Cadmium-Induced Testicular Damage in Mice

1973 • 162 citations

Effect of Cadmium Salts on Testicular Tissue

1956 • 162 citations

The Fate of Cd¹⁰⁹in the Mouse

1963 • 159 citations

Chromosome damage in human cell cultures induced by metal salts

1972 • 157 citations

Studies on metallothionein and cadmium

1978 • 149 citations

Observations on the early events of cadmium necrosis of the testis

1964 • 149 citations

Teratogenic Effect of Cadmium and its Inhibition by Zinc

1967 • 145 citations

The teratogenicity of cadmium chloride in two stocks of Wistar rats

1973 • 144 citations

Interrelationships of Selenium, Cadmium, and Arsenic in Mammalian Teratogenesis

1969 • 143 citations

Inducibility of chromosomal aberrations by metal compounds in cultured mammalian cells

1979 • 134 citations

Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium

1976 • 133 citations

Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice.

1976 • 132 citations

Cadmium residues in the environment

1973 • 123 citations

Teratogenic effects of cadmium in rats

1973 • 121 citations

THE THIRD OLIVER BIRD LECTURE STERILIZATION OF THE MALE BY CADMIUM SALTS

1960 • 121 citations

Placental transfer of lead, mercury, cadmium, and carbon monoxide in women

1978 • 114 citations

Sterilization of the male by cadmium salts.

1960 • 113 citations

CAUSATION OF OUCH-OUCH DISEASE (Itai-Itai Byo)-An Introductory Review

1969 • 112 citations

Developmental Malformations Induced by Cadmium

1971 • 108 citations

Effect of Zinc on Cancerogenesis by Cadmium.

1964 • 107 citations

Effects of cadmium on spermatogenesis studied by velocity sedimentation cell separation and serial mating.

1973 • 101 citations

Cadmium: Biological Effects and Occurrence in the Environment

1975 • 95 citations

Cadmium as a Carcinogen

1962 • 94 citations

Mutagenicity and metabolism studies on 12 thiuram and dithiocarbamate compounds used as accelerators in the Swedish rubber industry

1979 • 91 citations

Cadmium Neoplasia: Sarcomata at the Site of Injection of Cadmium Sulphate in Rats and Mice

1964 • 91 citations

Cytogenetic studies in 12 patients with Itai-Itai disease

1975 • 87 citations

Characterization of the proteinuria in cadmium-exposed workers

1976 • 85 citations

Cadmium induced limb defects in mice: Strain associated differences in sensitivity

1979 • 85 citations

POSSIBLE MECHANISMS OF CADMIUM FETOTOXICITY IN GOLDEN HAMSTERS AND MICE: UPTAKE BY THE EMBRYO, PLACENTA AND OVARY

1975 • 85 citations

Single-strand breakage in DNA of Escherichia coli exposed to Cd2+

1978 • 84 citations

Inhibition of mouse testicular DNA synthesis by mutagens and carcinogens as a potential simple mammalian assay for mutagenesis

1976 • 82 citations

Acute effects of cadmium on the pregnant rat and embryo-fetal development.

1979 • 77 citations

Manganese mutagenesis in yeast

1977 • 74 citations

Mutagenic effects of cadmium on mammalian oocyte chromosomes

1979 • 73 citations

Mouse liver metallothioneins. Purification, molecular weight, amino acid composition, and metal content.

1978 • 72 citations

Cadmium Neoplasia: Testicular Atrophy and Leydig Cell Hyperplasia and Neoplasia in Rats and Mice Following the Subcutaneous Injection of Cadmium Salts

1964 • 71 citations

Effect of metal cations on misincorporation by E. coli DNA polymerases

1977 • 71 citations

Metal carcinogenesis in experimental animals

1971 • 71 citations

Chromosome analysis of lymphocytes from cadmium workers and Itai-itai patients

1975 • 71 citations

STRAIN DIFFERENCES IN SUSCEPTIBILITY OF MICE AND RATS TO CADMIUM-INDUCED TESTICULAR DAMAGE

1965 • 69 citations

Chromosome studies in human lymphocytes after in vitro exposure to metal salts

1978 • 68 citations

Exposure and accumulation of cadmium in populations from Japan, the United States, and Sweden

1979 • 68 citations

The permeability of the hamster placenta to radioactive cadmium

1969 • 68 citations

Cadmium-induced Testicular Injury and Alterations of Androgen Synthesis in Brook Trout

1972 • 67 citations

Placental transfer of lead, mercury, cadmium, and carbon monoxide in women

1978 • 67 citations

Effect of cadmium on RNA‐polymerase and protein synthesis in rat liver

1976 • 66 citations

Investigations on the lung and kidney function in workers exposed to cadmium.

1979 • 66 citations

Environmental metallic carcinogens: An overview of exposure levels

1976 • 65 citations

EFFECT OF CADMIUM CHLORIDE ON THE PREGNANT ALBINO MOUSE

1965 • 65 citations

Cadmium-Induced Leydig Cell Tumors of Rat Testis: Morphologic and Cytochemical Study2

1973 • 64 citations

Effects of cadmium on nucleic acid and protein synthesis in rat liver

1976 • 64 citations

Metal Mutagens and Carcinogens Affect RNA Synthesis Rates in a Distinct Manner

1977 • 62 citations

Interaction of human DNA polymerase β with ions of copper, lead, and cadmium

1979 • 61 citations

Differential cadmium‐induced embryotoxicity in two inbred mouse strains 1. Analysis of inheritance of the response to cadmium and of the presence of cadmium in fetal and placental tissues

1974 • 58 citations

Trace metals: Exposure and health effects

1980 • 56 citations

Tumorigenesis by Cadmium

1972 • 55 citations

Chromosomal aberrations in bone-marrow cells of mice given a normal or a calcium-deficient diet supplemented with various heavy metals

1979 • 55 citations

The synteratogenic effect of lead and cadmium

1969 • 55 citations

Toxicity, fertility, teratogenicity, and dominant lethal tests in rats administered cadmium subchronically

1980 • 54 citations

Effects of cadmium on the immune system of mice

1979 • 54 citations

Cadmium, a metallic inhibitor of antibody-mediated immunity in mice

1978 • 54 citations

Cadmium and zinc abnormalities in bronchogenic carcinoma

1970 • 54 citations

Induction of Sarcoma in the Rat by Cadmium Sulphide Pigment

1963 • 54 citations

Chromosome analyses in cell cultures of the Chinese hamster after application of cadmiumsulphate

1976 • 52 citations

Metallothionein in a human cell line: The response of HeLa cells to cadmium and zinc

1979 • 51 citations

Protective Effect of Thiol Compounds Against Cadmium-Induced Vascular Damage to Testis.

1966 • 50 citations

The induction of sarcoma in the rat by cadmium sulphide and by cadmium oxide.

1966 • 49 citations

Chromosomal Aberrations in cultured Human Leucocytes induced by Cadmium Sulfide

1972 • 49 citations

Cellular changes induced by cadmium in mouse testis and liver.

1959 • 49 citations

Studies on the dominant-lethal and fertility effects of the heavy metal compounds methylmercuric hydroxide, mercuric chloride, and cadmium chloride in male and female mice

1975 • 49 citations

Factors affecting the induction of chromosomal aberrations by cadmium in Chinese hamster cells

1980 • 48 citations

Induction of cadmium-thionein in isolated rat liver cells

1978 • 47 citations

Methods to assess reproductive effects of environmental chemicals: studies of cadmium and boron administered orally.

1976 • 47 citations

Cadmium-induced alteration of drug action.

1978 • 46 citations

Nonspecific nature of the stimulus to DNA synthesis in cultures of chick embryo cells.

1975 • 45 citations

Skeletal Malformations Resulting from Cadmium Treatment in the Hamster

1973 • 44 citations

Chromosome studies on blood lymphocytes of men occupationally exposed to cadmium

1978 • 44 citations

Biochemical and physiologic changes in lungs of rats exposed to a cadmium chloride aerosol.

1978 • 44 citations

Facial formation in normal and cadmium-treated golden hamsters

1970 • 43 citations

Potential mutagenicity of cadmium in mammalian oocytes

1976 • 40 citations

Die Verteilung von Fragmentationen und achromatischen Stellen auf den Chromosomen von Vicia faba nach Behandlung mit Schwermetallsalzen

1956 • 40 citations

Multiplicity of cadmium binding sites in nucleotides: X-ray evidence for the involvement of O21′ and O3′ as well as phosphate and N7 in inosine 5′-monophosphate

1975 • 40 citations

Mutagenicity tests with cadmium in the mouse

1975 • 39 citations

Effect of Sodium Nitrilotriacetate on Toxicity, Teratogenicity, and Tissue Distribution of Cadmium

1972 • 39 citations

Ovarian changes in prepuberal rats after treatment with cadmium chloride.

1959 • 39 citations

Fetal effects of cadmium in pregnant rats on normal and zinc deficient diets

1978 • 37 citations

Mutagenicity of 19 major graphic arts and printing dyes

1978 • 36 citations

AN EXPERIMENTAL STUDY ON TERATOGENIC EFFECT OF CADMIUM

1973 • 36 citations

The effect of a single sublethal administration of cadmium chloride on the microcirculation in the uterus of the rat

1979 • 36 citations

In situ mutagenic and other effects associated with lead smelting

1978 • 36 citations

Effects of trisodium nitrilotriacetate on cadmium and methyl mercury toxicity and teratogenicity in rats

1972 • 36 citations

Chromosomal Abnormalities in Cultured Leucocyte Cells from Itai Itai Disease Patients

1972 • 35 citations

Infidelity of DNA Synthesis as Related to Mutagenesis and Carcinogenesis

1978 • 35 citations

Mutagenic effects of cadmium on the oocyte chromosomes of mice.

1977 • 34 citations

Cadmium modification of nucleolar ultrastructure and RNA synthesis in Physarum polycephalum

1978 • 33 citations

Nature of the repair process associated with the recovery of Escherichia coli after exposure to Cd2+

1977 • 32 citations

Metal-polynucleotide interactions A comparison of carcinogenic and non-carcinogenic metals in vitro

1976 • 32 citations

Inhalative cadmium effects in pregnant and fetal rats

1978 • 32 citations

Infidelity of DNA synthesis as related to mutagenesis and carcinogenesis

1977 • 32 citations

Cadmium Poisoning: I. The History of Cadmium Poisoning and Uses of Cadmium.

1932 • 31 citations

OBSERVATIONS ON CADMIUM DAMAGE AND REPAIR IN RAT TESTES AND THE EFFECTS ON THE PITUITARY GONADOTROPHS

1962 • 31 citations

Experimental confirmation in rats of the mixed type proteinuria observed in workers exposed to cadmium

1978 • 31 citations

Mutagens and potential mutagens in the biosphere II. Metals—Mercury, Lead, Cadmium and Tin

1974 • 31 citations

CADMIUM TOXICOLOGY

1969 • 31 citations

POTENTIAL CARCINOGENIC EFFECT OF CADMIUM IN ANIMALS AND MAN

1972 • 30 citations

The Protective Effect of Selenium on Cadmium-Induced Injury to Normal and Cryptorchid Testes in the Rat1

1978 • 29 citations

Molecular-genetic effects of cadmium chloride

1977 • 26 citations

Changes in rat carbohydrate metabolism after acute and chronic treatment with dichlorvos

1979 • 26 citations

The susceptibility of the fetus and child to chemical pollutants. Heavy metal exposures: toxicity from metal-metal interactions, and behavioral effects.

1974 • 25 citations

Cadmium accumulation and distribution in human lung fibroblasts

1980 • 25 citations

Mutagenic effect of some metal compounds on cultured mammalian cells

1978 • 24 citations

The interaction of cadmium‐binding proteins (Cd‐bp) and progesterone in cadmium‐induced tissue and embryo toxicity

1979 • 23 citations

STERILIZATION OF MALES BY INTRATESTICULAR ADMINISTRATION OF CADMIUM CHLORIDE

1962 • 23 citations

Cadmium-induced phagocyte cytotoxicity

1978 • 22 citations

Specific response of mesenchymal tissue to cancerigenesis by cadmium.

1967 • 22 citations

Cytogenetic investigations on leucocytes of cattle intoxicated with heavy metals

1974 • 21 citations

Cadmium‐induced alterations in RNA metabolism in cultures of Chinese hamster cells sensitive to and resistant to the cytotoxic effects of cadmium

1979 • 21 citations

Cd²⁺, Mn²⁺ and Zn²⁺ induced synthesis of nuclear RNA in the livers of normal and adrenalectomized rats

1970 • 20 citations

[Salmonella typhimurium as a test system for detecting the mutagenic activity of environmental pollutants. I. The mutagenic action of heavy metal salts in in vivo and in vitro systems without metabolic activation].

1977 • 20 citations

Comparison of the subacute effects of cadmium exposure upon nucleic acid, cyclic adenosine 3′, 5′-monophosphate and polyamine metabolism in lung and kidney cortex

1976 • 19 citations

Effects of trisodium nitrilotriacetate, trisodium citrate and a trisodium nitrilotriacetate-ferric chloride mixture on cadmium and methyl mercury toxicity and teratogenesis in rats

1972 • 19 citations

Some Immunological Effects of Lead, Cadmium and Methylmercury

1979 • 19 citations

Effects of cadmium on development time and prepupal puffing pattern of Drosophila melanogaster

2009 • 17 citations

Increased template activity in chromatin from cadmium chloride treated pea tissues

1973 • 17 citations

EFFECT OF TRIETHYLENEMELAMINE (TEM) AND CADMIUM CHLORIDE ON SPERMATOGENESIS IN RABBITS

1969 • 17 citations

Synthesis of DNA in the Liver and Testes of Cadmium-Treated Partially Hepatectomized Rats

1979 • 16 citations

Osservazioni Sull'Attività Citologica di Alcuni Composti Chimici

1950 • 16 citations

Histological Effects of Intra-Testicular Injections of Cadmium Chloride in Domestic Fowl

1964 • 15 citations

Synergistic interaction of gamma rays and some metallic salts in the induction of chlorophyll mutations in rice

1978 • 14 citations

Mutagenic effect of heavy metal salts on Salmonella in activation systems in vivo and in vitro

1977 • 13 citations

Genetic and cytogenetic hazards of heavy metals in mammals

1975 • 11 citations

Stimulation of informosomal RNA synthesis in cultured chinese hamster cells exposed to low levels of cadmium

1976 • 11 citations

Toxicity and mutagenicity of cadmium and furylfuramide in Drosophila melanogaster.

1978 • 11 citations

[Mutagenic action of cadmium on the sex cells of male mice].

1977 • 10 citations

Mutagenicity of heavy metals

1978 • 10 citations

Metal ion-nucleic acid interactions

1969 • 9 citations

[Absence of a mutagenic effect of cadmium and zinc salts in mouse somatic and sex cells].

1978 • 8 citations

Chromosome analyses in cell cultures of Chinese hamster after application of CdSO4

1976 • 8 citations

Preliminary studies on the effects of cadmium chloride on the meiotic chromosomes.

1977 • 8 citations

[Mutagenic effect of cadmium salts].

1976 • 8 citations

Toxic effects of cadmium and amaranth on the developing hamster embryo

1979 • 6 citations

[Salmonella typhimurium--test system for detecting the mutagenic activity of environmental pollutants. II. Mutagenic effect of heavy metal salts in an in vitro system with metabolic activation].

1977 • 6 citations

Induced sterility for coyote control: effect of cadmium chloride on potential fertility of the male canis familiaris.

1976 • 3 citations

Lead and cadmium inhibition of DNA biosynthesis

1974 • 2 citations