MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

Physiology and pharmacology of corticotropin-releasing factor.

1991 • 1,138 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The olfactory bulbectomised rat as a model of depression

2005 • 667 citations

Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

2002 • 351 citations

Interaction between α-Melanocyte-Stimulating Hormone and Corticotropin-Releasing Hormone in the Regulation of Feeding and Hypothalamo-Pituitary-Adrenal Responses

2003 • 225 citations

Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors

2000 • 218 citations

Corticotropin-Releasing Hormone

1988 • 175 citations

Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001.

1999 • 148 citations

Intracerebroventricular administration of α-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus

2002 • 133 citations

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450

2003 • 124 citations

Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor

2003 • 113 citations

Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat

1999 • 99 citations

Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents

2003 • 85 citations

The role of central melanocortin receptors in the activation of the hypothalamus‐pituitary‐adrenal‐axis and the induction of excessive grooming

1998 • 79 citations

Interaction between neuropeptide Y and alpha-melanocyte stimulating hormone in amygdala regulates anxiety in rats

2005 • 73 citations

Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats

1999 • 71 citations

Onset of the Effects of the 5-HT1A Antagonist, WAY-100635, Alone, and in Combination With Paroxetine, on Olfactory Bulbectomy and 8-OH-DPAT–Induced Changes in the Rat

1999 • 50 citations

Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats

1984 • 43 citations

An Investigation of Serotonergic Involvement in the Regulation of ACTH and Corticosterone in the Olfactory Bulbectomized Rat

1999 • 36 citations

The Determination of the Optimal Dose of Milnacipran in the Olfactory Bulbectomized Rat Model of Depression

1999 • 26 citations

Olfactory bulbectomy: Emotional behavior and defense responses in the rat

1979 • 25 citations

Effects of sertraline on regional neuropeptide concentrations in olfactory bulbectomized rats

2001 • 21 citations

Proconflict effect of ACTH1−24: Interaction with benzodiazepines

1990 • 18 citations