The Bioactive Phospholipid, Lysophosphatidylcholine, Induces Cellular Effects via G-Protein-dependent Activation of Adenylyl Cyclase

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

1981 • 1,655 citations

Molecular aspects of ligand binding to serum albumin.

1981 • 1,504 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

1992 • 828 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

Cytolytic and membrane-perturbing properties of lysophosphatidylcholine

1979 • 594 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

1985 • 388 citations

Role of secretory phospholipases A2 in the pathobiology of disease.

1986 • 382 citations

Biochemical mechanisms of platelet activation

1989 • 370 citations

Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

1985 • 365 citations

Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.

1994 • 332 citations

Biochemical mechanisms of platelet activation

1989 • 328 citations

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

1991 • 316 citations

Molecular and functional diversity of mammalian G _s ‐stimulated adenylyl cyclases

1993 • 295 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits

1995 • 276 citations

Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes.

1993 • 255 citations

Multiple pathway signal tran sduction by the cAMP‐dependent protein kinase

1994 • 241 citations

[12] Isolation of human platelets and platelet surface membranes

1974 • 213 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.

1986 • 196 citations

Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.

1994 • 196 citations

Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: effect of nutritionally induced atherosclerosis

1969 • 181 citations

Regulation of adenylate cyclase of human platelet membranes by forskolin.

1982 • 178 citations

Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step.

1986 • 158 citations

Regulation of guanylate and adenylate cyclase activities by lysolecithin.

1976 • 150 citations

Role of lysophosphatidylcholine in T-lymphocyte activation: involvement of phospholipase A2 in signal transduction through protein kinase C.

1992 • 143 citations

Purification and properties of prostaglandin E1/prostacyclin receptor of human blood platelets.

1987 • 136 citations

Platelet responses and metabolism

1986 • 133 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Transcriptional Induction of Endothelial Nitric Oxide Synthase Type III by Lysophosphatidylcholine

1995 • 113 citations

Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E1, and guanine nucleotides. Evidence for separate guanine nucleotide sites mediating stimulation and inhibition.

1979 • 108 citations

Serum Phospholipase A₂in Human Acute Pancreatitis

1980 • 105 citations

Induction of cyclooxygenase-2 in human umbilical vein endothelial cells by lysophosphatidylcholine.

1995 • 88 citations

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?

1982 • 84 citations

Identification of the serum factor required for in vitro activation of macrophages. Role of vitamin D3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages.

1991 • 80 citations

Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.

1993 • 58 citations

Lysolecithins as endothelium-dependent vascular smooth muscle relaxants that differ from endothelium-derived relaxing factor (nitric oxide)

1988 • 51 citations

An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase A2

1995 • 51 citations

Inhibition of prostaglandin synthesis by lysolecithin

1977 • 33 citations

Enhanced expression of thrombomodulin by intracellular cyclic AMP-increasing agents in two human megakaryoblastic leukemia cell lines

1990 • 28 citations

Stimulation of yeast adenylyl cyclase activity by lysophospholipids and fatty acids. Implications for the regulation of Ras/effector function by lipids.

1994 • 24 citations

Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Escherichia coli-synthesized Ha-ras-encoded p21.

1985 • 18 citations