Are peroxiredoxins tumor suppressors?

H ₂ O ₂ , a Necessary Evil for Cell Signaling

2006 • 2,018 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

Mitogen-activated protein kinases in apoptosis regulation

2004 • 1,403 citations

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

2003 • 1,317 citations

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

2006 • 1,042 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

2003 • 756 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

The isolation and purification of a specific “protector” protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system.

1988 • 483 citations

Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

2001 • 454 citations

Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice

2003 • 400 citations

Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria

2004 • 378 citations

Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism☆

2005 • 372 citations

Enhanced ROS Production in Oncogenically Transformed Cells Potentiates c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Activation and Sensitization to Genotoxic Stress

2001 • 312 citations

Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins

2004 • 310 citations

Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death

2005 • 293 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Regulation of Peroxiredoxin I Activity by Cdc2-mediated Phosphorylation

2002 • 241 citations

Reversible Oxidation of the Active Site Cysteine of Peroxiredoxins to Cysteine Sulfinic Acid

2003 • 232 citations

Human prx1 Gene Is a Target of Nrf2 and Is Up-regulated by Hypoxia/Reoxygenation: Implication to Tumor Biology

2007 • 223 citations

Overexpression of peroxiredoxin in human breast cancer.

2001 • 217 citations

Regulation of reactive oxygen species, DNA damage and c-Myc function by peroxiredoxin 1

2005 • 217 citations

A 2-Cys Peroxiredoxin Regulates Peroxide-Induced Oxidation and Activation of a Stress-Activated MAP Kinase

2004 • 212 citations

The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation

2002 • 193 citations

A Novel Role for Human Sulfiredoxin in the Reversal of Glutathionylation

2006 • 187 citations

A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress

2002 • 177 citations

Regeneration of Peroxiredoxins during Recovery after Oxidative Stress

2003 • 158 citations

Oxidation of a Eukaryotic 2-Cys Peroxiredoxin Is a Molecular Switch Controlling the Transcriptional Response to Increasing Levels of Hydrogen Peroxide

2005 • 155 citations

Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress

2007 • 146 citations

Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide

2005 • 144 citations

Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex

2006 • 143 citations

Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia

2006 • 134 citations

Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery

2006 • 129 citations

Identification of a Natural Killer Enhancing Factor (NKEF) from Human Erythroid Cells

1993 • 128 citations

Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress

2004 • 112 citations

Overexpression of human peroxiredoxin 5 in subcellular compartments of chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides

2003 • 111 citations

Redox Regulation of MAP Kinase Phosphatase 3

2006 • 103 citations

Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung

2006 • 102 citations

The Role of Peroxiredoxin II in Radiation-Resistant MCF-7 Breast Cancer Cells

2005 • 96 citations

Mouse translation elongation factor eEF1A‐2 interacts with Prdx‐I to protect cells against apoptotic death induced by oxidative stress

2006 • 95 citations

Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer

2006 • 93 citations

Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence

2005 • 73 citations

Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells

2006 • 67 citations

Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII‐null thymus

2004 • 47 citations

T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene

2005 • 47 citations

Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA

2006 • 43 citations

Peroxiredoxin I and II inhibit H₂O₂‐induced cell death in MCF‐7 cell lines

2007 • 42 citations

Inhibitory effect of peroxiredoxin II (Prx II) on Ras–ERK–NFκB pathway in mouse embryonic fibroblast (MEF) senescence

2006 • 31 citations