Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.

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1988 • 371 citations

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1983 • 305 citations

Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: Normolipemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia

1981 • 301 citations

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.

1995 • 272 citations

Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia.

1990 • 264 citations

An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.

1993 • 230 citations

Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance.

1993 • 198 citations

Familial combined hyperlipidaemia linked to the apolipoprotein AI–CIII–AIV gene cluster on chromosome 11q23q–q24

1991 • 188 citations

Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia.

1993 • 178 citations

A Common Variant in the Gene for Lipoprotein Lipase (Asp9→Asn)

1995 • 153 citations

Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus Relationships with lipids, apolipoproteins, and premature coronary artery disease

1991 • 148 citations

Familial combined hyperlipidemia and abnormal lipoprotein lipase.

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G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations.

1990 • 116 citations

DNA polymorphisms in and around the Apo-A1-CIII genes and genetic hyperlipidemias.

1987 • 113 citations

Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia

1996 • 110 citations

Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipoproteinemia.

1990 • 106 citations

Apolipoprotein A-I/C-III/A-IV gene cluster in familial combined hyperlipidemia: effects on LDL-cholesterol and apolipoproteins B and C-III.

1996 • 103 citations

Variation at the apo AI/CIII/A1V gene complex is associated with elevated plasma levels of apo CIII

1991 • 103 citations

Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: detection of genetic variation determining plasma apo AI, apo CIII and apo AIV concentrations

1992 • 101 citations

HLA Genotypic Study of Insulin-dependent Diabetes: The Excess of DR3/DR4 Heterozygotes Allows Rejection of the Recessive Hypothesis

1983 • 97 citations

Multilocus genetic determinants of LDL particle size in coronary artery disease families.

1996 • 94 citations

Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype.

1994 • 93 citations

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) contributes to the expression of familial combined hyperlipidemia

1995 • 93 citations

Genetics and molecular biology of familial combined hyperlipidemia

1993 • 83 citations

Genetic markers in the apo AI-CIII-AIV gene cluster for combined hyperlipidemia, hypertriglyceridemia, and predisposition to atherosclerosis

1993 • 82 citations

Association between genetic variation at the APO AI‐CIII‐AIV gene cluster and familial combined hyperlipidaemia

1994 • 77 citations

The LPL gene in individuals with familial combined hyperlipidemia and decreased LPL activity.

1994 • 77 citations

Polymorphism in the promoter region of the apolipoprotein AI gene associated with differences in apolipoprotein AI levels: The European Atherosclerosis Research Study

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DNA polymorphisms in the apolipoprotein C-III and insulin genes and atherosclerosis

1985 • 73 citations

A common variant in the gene for lipoprotein lipase (asp9 → asn): functional implications and prevalence in normal and hyperlipidemic subjects

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Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia.

1994 • 72 citations

The lipoprotein lipase (Asn291 → Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia

1996 • 71 citations

Inherited susceptibility determines the distribution of dense low-density lipoprotein subfraction profiles in familial combined hyperlipidemia.

1996 • 71 citations

Familial combined hyperlipidaemia: Use of stable isotopes to demonstrate overproduction of very low‐density lipoprotein apolipoprotein B by the liver

1990 • 69 citations

Complex segregation analysis provides evidence for a major gene acting on serum triglyceride levels in 55 British families with familial combined hyperlipidemia.

1994 • 67 citations

Genetic variation in the apolipoprotein AI-CIII-AIV gene cluster and coronary heart disease

1988 • 64 citations

Hypertriglyceridemia and the apolipoprotein CIII gene locus: lack of association with the variant insulin response element in Italian school children

1996 • 61 citations

Postprandial decrease in HDL cholesterol and HDL apo A-I in normal subjects in relation to triglyceride metabolism

1991 • 57 citations

Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia.

1994 • 49 citations

Evidence Against Linkage of Familial Combined Hyperlipidemia to the Apolipoprotein AI-CIII-AIV Gene Complex

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Complex Segregation Analysis of Hyperlipidemia in a Seattle Sample

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Familial combined hyperlipidaemia: 1973-1991.

1992 • 35 citations

Pedigree and sib-pair linkage analysis suggest the apolipoprotein B gene is not the major gene influencing plasma apolipoprotein B levels.

1992 • 29 citations

Genetic evidence from 7 families that the apolipoprotein B gene is not involved in familial combined hyperlipidemia

1990 • 29 citations

Complex Segregation Analysis of Hypertriglyceridemia

1981 • 11 citations

No evidence for linkage between familial hypertriglyceridemia and apolipoprotein B, apolipoprotein C-III or lipoprotein lipase genes

1994 • 10 citations

Molecular Genetics of Coronary Heart Disease

1988 • 4 citations

Molecular genetics of coronary heart disease

1988 • 4 citations

Familial Combined Hyperlipidemia

2016 • 4 citations

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