Analysis of Mitochondrial Targeting Sequence and Coding Region Polymorphisms of the Manganese Superoxide Dismutase Gene in German Parkinson Disease Patients

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Mitochondrial Superoxide Dismutase

1973 • 965 citations

Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria

1986 • 723 citations

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1998 • 497 citations

Structural Dimorphism in the Mitochondrial Targeting Sequence in the Human Manganese Superoxide Dismutase Gene

1996 • 494 citations

The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles

1992 • 448 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

1989 • 445 citations

Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.

1990 • 382 citations

Oxygen toxicity protecting enzymes in Parkinson's disease

1988 • 239 citations

On signal sequence polymorphisms and diseases of distribution.

1996 • 230 citations

Molecular Structure and Organization of the Human Manganese Superoxide Dismutase Gene

1994 • 213 citations

Human Mitochondrial Manganese Superoxide Dismutase Polymorphic Variant Ile58Thr Reduces Activity by Destabilizing the Tetrameric Interface^,

1996 • 182 citations

Inactivation of the human CuZn superoxide dismutase during exposure to O2− and H2O2

1981 • 176 citations

The Mitochondrial Targeting function of Randomly Generated Peptide Sequences Correlates with Predicted Helical Amphiphilicity

1989 • 164 citations

Protein translocation across mitochondrial membranes: What a long, strange trip it is

1995 • 129 citations

Sublocalization of the gene encoding manganese superoxide dismutase (MnSOD/SOD2) to 6q25 by fluorescence in Situ hybridization and somatic cell hybrid mapping

1992 • 105 citations

On signal sequence polymorphims and diseases of distribution

1996 • 85 citations

Regulation of the Manganese Superoxide Dismutase and Inducible Nitric Oxide Synthase Gene in Rat Neuronal and Glial Cells

1996 • 76 citations

Mn SOD activity and protein in a patient with chromosome 6-linked autosomal recessive parkinsonism in comparison with Parkinson's disease and control

1997 • 74 citations

Use of neuropathological tissue for molecular genetic studies: parameters affecting DNA extraction and polymerase chain reaction

1994 • 73 citations

Distribution of manganese-dependent superoxide dismutase in the human brain

1994 • 65 citations

Modulation of Oxygen-Radical-Scavenging Enzymes by Oxidative Stress in Primary Cultures of Rat Astroglial Cells

1996 • 54 citations

Absence of Mutations in Superoxide Dismutase and Catalase Genes in Patients With Parkinson's Disease

1995 • 38 citations

An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease

1997 • 36 citations

Preferential expression of superoxide dismutase messenger RNA in melanized neurons in human mesencephalon

1993 • 35 citations

Superoxide Dismutase Expression in Parkinson's Disease

1994 • 31 citations

Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator.

1998 • 17 citations