The colony stimulating factors discovery, development, and clinical applications

THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO

1966 • 1,944 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Human bone marrow colony growth in agar‐gel

1970 • 1,317 citations

Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells

1986 • 1,260 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium

1988 • 961 citations

Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor

1986 • 831 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation

1988 • 779 citations

EFFECT OF GRANULOCYTE COLONY STIMULATING FACTOR ON NEUTROPENIA INDUCED BY CYTOTOXIC CHEMOTHERAPY

1988 • 740 citations

Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells.

1977 • 740 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced Myelosuppression

1988 • 689 citations

Effects of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor in Patients with Myelodysplastic Syndromes

1987 • 653 citations

Effect of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor on Myelopoiesis in the Acquired Immunodeficiency Syndrome

1987 • 633 citations

Purification and properties of colony-stimulating factor from mouse lung-conditioned medium.

1977 • 624 citations

Induction of Colonies of Hemoglobin-Synthesizing Cells by Erythropoietin In Vitro

1971 • 620 citations

Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer

1987 • 605 citations

Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor.

1983 • 568 citations

The Hemopoietic Colony-stimulating Factors

1995 • 565 citations

Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)

1985 • 542 citations

Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor.

1985 • 522 citations

Purified Human Granulocyte-Macrophage Colony-Stimulating Factor: Direct Action on Neutrophils

1984 • 506 citations

Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on Neutropenia in Patients with Congenital Agranulocytosis

1989 • 495 citations

Molecular cloning of cDNA for murine interleukin-3

1984 • 485 citations

Hemopoietic colony-stimulating factors

1984 • 468 citations

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte—macrophage colony stimulating factor

1984 • 451 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Procedures for the purification of interleukin 3 to homogeneity.

1982 • 428 citations

Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates.

1987 • 428 citations

Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF

1986 • 405 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

1984 • 365 citations

The induction of clones of normal mast cells by a substance from conditioned medium

1966 • 358 citations

Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin.

1977 • 334 citations

Hierarchical down-modulation of hemopoietic growth factor receptors

1985 • 314 citations

Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice

1986 • 313 citations

Phase I/II study of recombinant human granulocyte-macrophage colony- stimulating factor in aplastic anemia and myelodysplastic syndrome

1988 • 301 citations

Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial

1989 • 293 citations

Growth of mouse megakaryocyte colonies in vitro.

1975 • 289 citations

Hemopoietic responses in mice injected with purified recombinant murine GM-CSF.

1987 • 284 citations

Pregnancy-specific beta-glycoprotein in complications of early pregnancy.

1980 • 280 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies

1988 • 271 citations

Purification and characterization of human granulocyte colony-stimulating factor (G-CSF).

1986 • 243 citations

Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.

1987 • 239 citations

Production of Colony-Stimulating Factor in Mitogen-Stimulated Lymphocyte Cultures

1974 • 213 citations

Molecules stimulating early red cell, granulocyte, macrophage, and megakaryocyte precursors in culture: Similarity in size, hydrophobicity, and charge

1982 • 207 citations

Acute antigen-induced elevation of serum colony stimulating factor (CFS) levels.

1971 • 206 citations

In Vitro Growth of Granulocytic and Mononuclear Cell Colonies From Blood of Normal Individuals

1971 • 202 citations

The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6

1988 • 198 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

Effects of Bacterially Synthesized Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Advanced Malignancy

1989 • 194 citations

Characterization and partial purification of a haemopoietic cell growth factor in WEHI-3 cell conditioned medium

1983 • 192 citations

Stimulation by normal and leukemic mouse sera of colony formation in vitro by mouse bone marrow cells

1967 • 192 citations

Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor.

1986 • 188 citations

FACTORS FROM MOUSE TISSUES STIMULATING COLONY GROWTH OF MOUSE BONE MARROW CELLS IN VITRO

1971 • 187 citations

Subcutaneous granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome: toxicity, pharmacokinetics, and hematological effects.

1989 • 179 citations

Hematopoietic responses in patients with advanced malignancy treated with recombinant human granulocyte-macrophage colony-stimulating factor.

1989 • 179 citations

A low molecular weight factor in lung‐conditioned medium stimulating granulocyte and monocyte colony formation in vitro

1973 • 172 citations

Characterization of a serum factor stimulating the differentiation of myelomonocytic leukemic cells

1980 • 170 citations

Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway.

1987 • 161 citations

Protective effect of human granulocyte colony-stimulating factor on microbial infection in neutropenic mice

1987 • 160 citations

Formation of eosinophilic‐like granulocytic colonies by mouse bone marrow cells in vitro

1974 • 148 citations

Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors.

1980 • 147 citations

The molecular control of blood cells

1988 • 146 citations

Colony Formation <italic>In Vitro</italic> by Myelomonocytic Leukemic Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 138 citations

Bone Marrow Colony Stimulating Activity in Human Sera. RESULTS OF TWO INDEPENDENT SURVEYS IN BUFFALO AND MELBOURNE*

1968 • 125 citations

Purified colony stimulating factors (G‐CSF and GM‐CSF) induce differentiation in human HL60 leukemic cells with suppression of clonogenicity

1987 • 125 citations

Production by spleen and lymph node cells of conditioned medium with erythroid and other hemopoietic colony‐stimulating activity

1978 • 124 citations

Colony stimulating factor and the regulation of granulopoiesis and macrophage production.

1975 • 122 citations

Tissue sources of bone marrow colony stimulating factor

1971 • 117 citations

Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression

1989 • 109 citations

Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.

1988 • 107 citations

Brief Report: Stimulation of Bone Marrow Colony Growth In Vitro by Human Urine

1969 • 98 citations

Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells.

1989 • 93 citations

Recombinant human macrophage colony-stimulating factor (M-CSF) requires subliminal concentrations of granulocyte/macrophage (GM)-CSF for optimal stimulation of human macrophage colony formation in vitro.

1987 • 89 citations

Recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) given as daily short infusions – a phase I dose-toxicity study

1989 • 85 citations

Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.

1989 • 79 citations

Quantitative responsiveness of murine hemopoietic populations in vitro and in vivo to recombinant multi-CSF (IL-3).

1987 • 78 citations

Detection of a new type of mouse eosinophil colony by Luxol-fast-blue staining.

1980 • 75 citations

Purification of a multipotential colony-stimulating factor from pokeweed mitogen-stimulated mouse spleen cell conditioned medium.

1985 • 72 citations

The roles of stem cell self-renewal and autocrine growth factor production in the biology of myeloid leukemia.

1989 • 69 citations

Purification and partial amino acid sequence of asialo murine granulocyte-macrophage colony stimulating factor.

1985 • 66 citations

Effect of interleukin 6 (IL-6) on the differentiation and proliferation of murine and human hemopoietic progenitors.

1988 • 64 citations

Preparation and neutralization characteristics of an anti-CSF antibody

1975 • 62 citations

Multi-CSF-dependent colony formation by cells of a murine hemopoietic cell line: specificity and action of multi-CSF

1985 • 61 citations

Clonal suppression of HL60 and U937 cells by recombinant human leukemia inhibitory factor in combination with GM-CSF or G-CSF.

1989 • 60 citations

Nucleotide sequence of a cDNA encoding murine CSF-1 (Macrophage-CSF)

1987 • 57 citations

Enhanced suppression of human myeloid leukemic cell lines by combinations of IL‐6, LIF, GM‐CSF and G‐CSF

1990 • 53 citations

Generation of an autocrine leukaemia using a retroviral expression vector carrying the interleukin-3 gene.

1986 • 51 citations

Regulator‐induced suppression of myelomonocytic leukemic cells: Clonal analysis of early cellular events

1982 • 46 citations

Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors

1989 • 44 citations

Bone Marrow Colony-stimulating Activity of Sera in Infectious Mononucleosis

1968 • 44 citations

The Molecular Control of Blood Cells

1989 • 40 citations

The presence of mast cells in agar cultures.

1980 • 38 citations

Granulocyte-Macrophage Precursor Cell and Colony-Stimulating Factor Responses of Mice Infected with Salmonella typhimurium

1973 • 36 citations

Biological Activities of Recombinant Human Granulocyte Colony Stimulating Factor (rhG-CSF) and Tumor Necrosis Factor: In Vivo and In Vitro Analysis

1987 • 34 citations

Stimulation by human urine or plasma of granulopoiesis by human marrow cells in agar.

1974 • 28 citations

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates immature marrow precursors but no CFU-GM, CFU-G, or CFU-M.

1989 • 27 citations

Selective stimulation by mouse spleen cell conditioned medium of human eosinophil colony formation

1983 • 24 citations

Hemopoietic Colony-Forming Cell Responses in Mice Infected with Ectromelia Virus

1971 • 14 citations

Constitutive expression of hematopoietic growth factor genes by acute myeloblastic leukemia cells.

1988 • 8 citations

The molecular cloning of interleukins 4, 5 and 6: multifunctional hemopoietic growth factors.

1988 • 6 citations