Enzymatic synthesis and function of folylpolyglutamates

Chemistry and biology of pteridines

1956 • 1,263 citations

Role of Mineral Elements with Emphasis on the Univalent Cations

1966 • 548 citations

Enzymes Activated by Monovalent Cations

1970 • 424 citations

Mammalian methylenetetrahydrofolate reductase Partial purification, properties, and inhibition by S-adenosylmethionine

1971 • 349 citations

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

1971 • 291 citations

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1974 • 277 citations

Multifunctional Proteins

1976 • 221 citations

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.

1980 • 215 citations

Physical and chemical properties of polysaccharides and glycoproteins of the yeast-cell wall

1960 • 193 citations

The Mechanism of the Condensation of Formaldehyde with Tetrahydrofolic Acid

1966 • 191 citations

Microbial growth on C1 compounds. 5. Enzyme activities in extracts of Pseudomonas AM1

1963 • 188 citations

The Biosynthesis of Folic Acid

1964 • 182 citations

Lactobacillus casei response to pteroylpolyglutamates

1972 • 156 citations

Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

1974 • 145 citations

Purification and Properties of 5-Methyltetrahydropteroyltriglutamate-Homocysteine Transmethylase

1970 • 135 citations

Folate-dependent enzymes in cultured Chinese hamster cells: Folylpolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine

1977 • 133 citations

Identification of folic acid compounds in rat liver

1972 • 123 citations

Formyl-methyl-methylenetetrahydrofolate synthetase-(combined). An ovine protein with multiple catalytic activities.

1976 • 122 citations

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

1979 • 118 citations

Folate metabolism in mammalian cells in culture. I Partial characterization of the folate derivatives present in L1210 mouse leukemia cells.

1976 • 116 citations

Interactions of pig liver methylenetetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors

1980 • 115 citations

Human thymidylate synthetase. II. Derivatives of pteroylmono- and -polyglutamates as substrates and inhibitors.

1978 • 110 citations

Formyltetrahydrofolate Synthetase

1962 • 109 citations

ON THE PEPTIDE NATURE OF VITAMIN Bc CONJUGATE FROM YEAST

1946 • 108 citations

NATURALLY OCCURRING FOLATES

1971 • 104 citations

NATURALLY OCCURRING FOLATES

1971 • 103 citations

The identification of pteroylpentaglutamate as the major folate derivative in rat liver and the demonstration of its biosynthesis from exogenous [3H] pteroylglutamate

1972 • 102 citations

Dihydrofolic Reductase from Streptococcus faecalis R

1961 • 101 citations

Enzymatic Synthesis of the Methyl Group of Methionine

1964 • 97 citations

7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources

1974 • 95 citations

Transport and metabolism of folates by bacteria.

1975 • 94 citations

5-Methyl-5,6,7,8-tetrahydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with methionine synthetase from bovine brain

1975 • 86 citations

Serine Transhydroxymethylase. Affinity of Tetrahydrofolate Compounds for the Enzyme and Enzyme-Glycine Complex^*

1967 • 85 citations

Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties.

1976 • 83 citations

Studies on γ-glutamyl carboxypeptidase I. The solid phase synthesis of analogs of polyglutamates of folic acid and their effects on human liver γ-glutamyl carboxypeptidase

1970 • 83 citations

Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells.

1972 • 82 citations

Unique catalytic properties of enzyme clusters

1978 • 81 citations

Purification of a complex catalyzing folate cofactor synthesis and transformylation in de novo purine biosynthesis.

1980 • 78 citations

Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Purification and properties of folypoly(gamma-glutamate) synthetase.

1980 • 78 citations

Tetrahydropteroylpolyglutamate derivatives as substrates of two multifunctional proteins with folate-dependent enzyme activities

1980 • 77 citations

Formyltetrahydrofolate Synthetase

1972 • 75 citations

Folylpoly-.gamma.-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase

1979 • 75 citations

Folate Coenzymes of Lactobacillus casei and Streptococcus faecalis

1974 • 75 citations

Stereospecificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

1979 • 73 citations

Enzymes of Clostridial Purine Fermentation

1967 • 72 citations

On the Vitamin B _c Conjugate in Yeast

1944 • 70 citations

Identification of folate binding proteins in rat liver.

1977 • 70 citations

Folate Coenzymes of Clostridium acidi-urici

1972 • 64 citations

ON THE ENZYMIC FORMATION OF VITAMIN B FROM ITS CONJUGATE

1945 • 60 citations

Formyltetrahydrofolate Synthetas

1973 • 59 citations

Inhibition of thymidylate synthetase and dihydrofolate reductase by naturally occurring oligoglutamate derivatives of folic acid.

1975 • 59 citations

Methionine synthesis by extracts of Salmonella typhimurium

1966 • 58 citations

Methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer RNA of Streptococcus faecalis. Evidence for reduction of the 1-carbon unit by FADH2.

1980 • 58 citations

Identification of a folate binder in hog kidney.

1975 • 54 citations

Uptake of pteroyl[¹⁴C]glutamic acid into rat liver and its incorporation into the natural pteroyl poly-γ-glutamates of that organ

1974 • 54 citations

Folate Composition, Synthesis and Function in Natural Materials

1976 • 54 citations

The Enzymatic Synthesis of Thymidylate

1962 • 54 citations

Transport and utilization of methyltetrahydrofolates by Lactobacillus casei.

1976 • 53 citations

The synthesis of pteroylpolyglutamates by sheep liver enzymes in vitro

1973 • 52 citations

Polyglutamate derivatives of folic acid coenzymes and methotrexate

1980 • 52 citations

Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on liver constituents associated with folate metabolism

1974 • 51 citations

Synthesis and biological evaluation of poly-.gamma.-glutamyl derivatives of methotrexate

1973 • 51 citations

Oxidative and reductive cleavage of folates—A critical appraisal

1979 • 51 citations

The substrate specificity of 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase

1969 • 50 citations

Folic acid and the synthesis of methionine by extracts of Escherichia coli

1961 • 49 citations

Partial purification and properties of an enzyme from Escherichia coli that catalyzes the conversion of glutamic acid and 10-formyltetrahydropteroylglutamic acid to 10-formyltetrahydropteroyl-.gamma.-glutamylglutamic acid

1975 • 49 citations

The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants

1969 • 49 citations

Identification of folate binding protein of mitochondria as dimethylglycine dehydrogenase.

1980 • 48 citations

The Turnover of Folate Coenzymes in Murine Lymphoma Cells

1973 • 46 citations

Enzyme Studies with New Analogues of Folic Acid and Homofolic Acid

1967 • 46 citations

Subcellular localization of γ-glutamyl carboxypeptidase and of folates

1976 • 44 citations

Lack of stereospecificity at carbon 6 of methyltetrahydrofolate transport in Ehrlich ascites tumor cells. Carrier-mediated transport of both stereoisomers.

1978 • 44 citations

Pentaglutamate Derivatives of Folate as Substrates for Rat Liver Tetrahydropteroylglutamate Methyltransferase and 5,10-Methylenetetrahydrofolate Reductase

1975 • 44 citations

Synchronization of Converging Metabolic Pathways: Activation of the Cystathionine γ-Synthase of Neurospora crassa by Methyltetrahydrofolate

1971 • 42 citations

THE RÔLE OF POLYGLUTAMYL PTERIDINE COENZYMES IN SERINE METABOLISM

1956 • 40 citations

METHYLCOBALAMIN* AS A SOURCE OF THE METHYL GROUP OF METHIONINE

1964 • 39 citations

Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacilluscasei thymidylate synthetase

1976 • 39 citations

THE RÔLE OF POLYGLUTAMYL PTERIDINE COENZYMES IN SERINE METABOLISM

1956 • 39 citations

The interconversion of serine and glycine: some further properties of the enzyme system

1957 • 39 citations

FOLIC ACID DERIVATIVES SYNTHESIZED DURING GROWTH OF DIPLOCOCCUS PNEUMONIAE

1963 • 38 citations

Evidence for the symbiotic origin of mitochondria

1974 • 38 citations

Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme

1978 • 37 citations

Metabolism of Formiminoglycine

1967 • 35 citations

Dihydrofolic Acid Reductase of Calf Thymus^*

1962 • 35 citations

Interrelations Between Two Pathways of Methionine Biosynthesis in Aerobacter aerogenes

1965 • 33 citations

Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Studies on the mechanism of folypoly(gamma-glutamate) synthetase.

1980 • 33 citations

Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. In vivo synthesis of folates.

1980 • 32 citations

Purification and properties of dihydrofolate reductase of sheep liver

1964 • 32 citations

Purification and properties of N5, N10-methylenetetrahydrofolate dehydrogenase of calf thymus

1965 • 32 citations

Folate coenzyme pattern, folate linked enzymes and methionine biosynthesis in rat liver mitochondria.

1967 • 31 citations

Differential inhibition of host and viral thymidylate synthetases by folylpolyglutamates.

1979 • 31 citations

Folate-dependent enzymes in cultured chinese hamster ovary cells: Evidence for mutant forms of folylpolyglutamate synthetase

1979 • 30 citations

A new synthetic route to quinazoline analogs of folic acid

1975 • 30 citations

Pteroic Acid Derivatives. III. Pteroyl-γ-glutamylglutamic Acid and Pteroyl-γ-glutamyl-γ-glutamylglutamic Acid

1949 • 29 citations

Protective effect of the pteroylpolyglutamates and phosphate on the proteolytic inactivation of thymidylate synthetase

1977 • 29 citations

Growth inhibitory, transport and biochemical properties of the γ-glutamyl and γ-aspartyl peptides of methotrexate inL1210 leukemia cells in vitro

1978 • 29 citations

The Identification of Hexa-, Hepta- and Octoglutamates as the Polyglutamyl Forms of Folate Found throughout the Growth Cycle of Yeast

1976 • 29 citations

Mammalian folate metabolism. Regulation of folate interconversion enzymes

1973 • 28 citations

Highly purified dihydrofolate reductase of calf thymus

1966 • 28 citations

Polyglutamate Forms of Folate in Resting and Proliferating Mammalian Tissues

1975 • 27 citations

Differential inhibition of erythrocyte and hepatic uroporphyrinogen 1 synthetase activity by lead

1974 • 25 citations

Folates of rat tissue

1979 • 24 citations

Folic acid and the methylation of homocysteine by Bacillus subtilis

1972 • 24 citations

Pteroic Acid Derivatives. V. Pteroyl-α-glutamyl-α-glutamylglutamic Acid, Pteroyl-γ-glutamyl-α-glutamylglutamic Acid, Pteroyl-α-glutamyl-γ-glutamylglutamic Acid

1949 • 23 citations

The microbial biosynthesis of methionine

1972 • 23 citations

6 Folate Coenzyme-Mediated Transfer of One-Carbon Groups

1973 • 23 citations

Rate-limiting Steps in Folate Metabolism by Lactobacillus casei

1977 • 22 citations

Regulation of dihydrofolate reductase and other folate-requiring enzymes

1968 • 21 citations

Studies on the Uptake of Synthetic Conjugated Folates by Human Marrow Cells

1973 • 21 citations

Pteridine regulation of inhibition of hepatic uroporphyrinogen L synthetase activity by lead chloride.

1977 • 20 citations

The determination of folylpolyglutamate synthetase

1975 • 19 citations

Binding of substrate to N5-methyl-tetrahydropteroyltriglutamate-homocysteine transmethylase

1968 • 19 citations

Folic acid coenzymes.

1960 • 19 citations

The peracid cleavage of 5-methyltetrahydrofolic acid at the C9N10 bridge

1979 • 18 citations

Folate polyglutamates in T4D bacteriophage and T4D-infected Escherichia coli

1978 • 18 citations

Metabolism of 5-Methyltetrahydrofolate by Lactobacittus casei

1977 • 17 citations

Enzymes of the clostridial purine fermentation

1968 • 16 citations

Co-purification of three folate enzymes from porcine liver

1973 • 16 citations

[Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism].

1961 • 15 citations

The purification of formiminotransferase and cyclodeaminase by combination of affinity chromatography and isoelectric focusing

1974 • 13 citations

Synthesis and breakdown of natural folates (folate polyglutamates).

1975 • 12 citations

Early work with folic acid.

1979 • 12 citations

Inhibition of 5,10-methylenetetrahydrofolate dehydrogenase by the d,L-diastereoisomer of 5,10-methylenetetrahydrofolate

1964 • 12 citations

The Effect of the Exogenous Folate Concentration on the Biosynthesis of Pteroylpolyglutamates in Lactobacillus casei and the Folate Polyglutamate Distribution in Escherichia coli

1976 • 7 citations

Folyl polyglutamate and folate-requiring enzymes as bacteriophage T4D baseplate structural components

1980 • 4 citations

[Research on monocarbon compounds. III. Research on the mechanism of tetrahydrofolate formylase].

1961 • 1 citations