Polycystic Kidney Disease as a Result of Loss of the Tuberous Sclerosis 2 Tumor Suppressor Gene During Development

Autosomal Dominant Polycystic Kidney Disease

1993 • 980 citations

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1995 • 893 citations

Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease — a contiguous gene syndrome

1994 • 492 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

1994 • 305 citations

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer

1995 • 301 citations

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

1999 • 242 citations

Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines.

1995 • 169 citations

Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.

1993 • 164 citations

Expression of transforming growth factor alpha and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue.

1989 • 160 citations

A Dominant Gene for Renal Adenomas in the Rat

1961 • 155 citations

Tuberin-Dependent Membrane Localization of Polycystin-1

2001 • 151 citations

Expression of transforming growth factor alpha in normal human adult kidney and enhanced expression of transforming growth factors alpha and beta 1 in renal cell carcinoma.

1989 • 143 citations

Polycystin

2001 • 125 citations

Rodent model of reproductive tract leiomyomata. Clinical and pathological features.

1995 • 121 citations

Hereditary Renal Cell Carcinoma in the Eker Rat: A Rodent Familial Cancer Syndrome

1992 • 118 citations

Molecular Genetics and Pathogenesis of Autosomal Dominant Polycystic Kidney Disease

2001 • 115 citations

Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation

2000 • 104 citations

Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo.

1995 • 103 citations

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

1998 • 102 citations

FAMILIAL RENAL ADENOMAS IN WISTAR RATS

1954 • 97 citations

Predisposition to Renal Cell Carcinoma Due to Alteration of a Cancer Susceptibility Gene

1992 • 83 citations

Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.

1995 • 74 citations

The Genetics of Wilms' Tumor

1992 • 73 citations

A large TSC2 and PKD1 gene deletion is associated with renal and extrarenal signs of autosomal dominant polycystic kidney disease

1997 • 69 citations

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat

1995 • 68 citations

Biology of polycystic kidney disease.

1994 • 68 citations

Carcinogenicity of a Nephrotoxic Metabolite of the “Nongenotoxic” Carcinogen Hydroquinone

2000 • 67 citations

Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.

1993 • 66 citations

Altered expression of transforming growth factor-alpha in hereditary rat renal cell carcinoma.

1991 • 61 citations

Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat.

1994 • 58 citations

Autosomal dominant polycystic kidney disease: molecular genetics and molecular pathogenesis

2000 • 58 citations

Intragenic Tsc2 Somatic Mutations as Knudson's Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model

1997 • 50 citations

Allelic Loss at the Tuberous Sclerosis (Tsc2) Gene Locus in Spontaneous Uterine Leiomyosarcomas and Pituitary Adenomas in the Eker Rat Model

1995 • 42 citations

Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo

1995 • 38 citations

Polycystic kidney disease: hereditary and acquired.

1993 • 36 citations

Somatic Mutation of the Tuberous Sclerosis (Tsc2) Tumor Suppressor Gene in Chemically Induced Rat Renal Carcinoma Cell

1997 • 35 citations

Role of the WT1 gene in Wilms' tumour.

1992 • 34 citations

Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat.

1993 • 32 citations

Altered expression of transforming growth factor-α: An early event in renal cell carcinoma development

1997 • 31 citations

Biallelic mutations of theTsc2 gene in chemically induced rat renal cell carcinoma

1998 • 31 citations

The TSC2/PKD1 Contiguous Gene Syndrome

1997 • 26 citations

Determination of loss of heterozygosity in frozen and paraffin embedded tumors by denaturating high-performance liquid chromatography (DHPLC)

2001 • 23 citations

Preneoplastic and Neoplastic Lesions of Rat Hereditary Renal Cell Tumors Express Markers of Proximal and Distal Nephron

1995 • 17 citations

An ever-expanding story of cyst formation

2000 • 10 citations

Tissue-specific Expression and Splicing of the Rat Polycystic Kidney Disease 1 Gene

2001 • 9 citations

Spontaneous hemangiosarcoma in the tail of a Long-Evans rat carrying the Eker mutation.

1994 • 6 citations