em BRCA1 em in cancer cell cycle and genomic stability

DNA double-strand breaks: signaling, repair and the cancer connection

2001 • 2,372 citations

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

2002 • 1,676 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Differences in Breast Cancer Stage, Treatment, and Survival by Race and Ethnicity

2003 • 659 citations

The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals

1995 • 657 citations

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

2001 • 655 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

2001 • 626 citations

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

1998 • 625 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

2002 • 526 citations

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1997 • 525 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

2002 • 473 citations

Recombinational DNA repair and human disease

2002 • 421 citations

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

2001 • 357 citations

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1999 • 353 citations

Tumour biological features of BRCA1-induced breast and ovarian cancer

1997 • 346 citations

Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study.

1996 • 337 citations

BRCA1 interacts with components of the histone deacetylase complex

1999 • 330 citations

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

1998 • 324 citations

Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

1995 • 301 citations

Direct DNA binding by Brca1

2001 • 277 citations

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

2002 • 254 citations

Incidence of Invasive Breast Cancer by Hormone Receptor Status From 1992 to 1998

2002 • 247 citations

BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

1998 • 237 citations

Functions of BRCA1 and BRCA2 in the biological response to DNA damage

2001 • 237 citations

Regulation of tumor suppressors by nuclear-cytoplasmic shuttling

2003 • 231 citations

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase

2002 • 218 citations

Inherited breast and ovarian cancer

1995 • 212 citations

Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein

2003 • 199 citations

CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

1998 • 192 citations

Breast cancer genetics in African Americans

2002 • 177 citations

Complex Regulation of the BRCA1 Gene

1997 • 148 citations

Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region

1998 • 135 citations

The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans

2002 • 116 citations

BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site

1999 • 115 citations

DNA Methylation de Novo

1999 • 109 citations

Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression

2000 • 99 citations

Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer.

1995 • 98 citations

Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene

1997 • 84 citations

Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1

2001 • 80 citations

Cell Cycle Differences in DNA Damage-induced BRCA1 Phosphorylation Affect Its Subcellular Localization

2003 • 79 citations

Repression of BRCA1 through a Feedback Loop Involving p53

2000 • 71 citations

Truncation at conserved terminal regions of BRCA1 protein is associated with highly proliferating hereditary breast cancers.

1996 • 67 citations

The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21.

1996 • 62 citations

Functional analysis of CpG methylation in the BRCA1 promoter region

2001 • 57 citations

Promoter Hypermethylation and Post-transcriptional Mechanisms for Reduced BRCA1 Immunoreactivity in Sporadic Human Breast Cancers

2002 • 50 citations

Cytoplasmic Occurrence of the Chk1/Cdc25 Pathway and Regulation of Chk1 in Xenopus Oocytes

2001 • 50 citations

A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression

1996 • 42 citations

Roles of BRCA1 and its interacting proteins

2000 • 42 citations

Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers

2002 • 41 citations

Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the Neurofibromatosis type 1 (NF1) tumour-suppressor gene

1997 • 38 citations

Role of BRCA1 in heat shock response

2003 • 35 citations

Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.

2002 • 34 citations

Gene-Expression Profiles in Hereditary Breast Cancer

2001 • 28 citations

BRCA1-associated growth arrest is RB-dependent

1999 • 20 citations

Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

1999 • 11 citations